Research Article

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Previous studies have suggested that an association exists between the proline dehydrogenase gene (PRODH) and increased schizophrenia risk. We examined the prevalence of the PRODH 757C/T (Arg185Trp), 1766A/G (Gly521Arg), and 1852G/A (intronic mutation) polymorphisms in 175 patients with schizophrenia and 185 control subjects. All subjects were of Iranian ancestry. The ... more

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Fixed-effect analysis; Meta-analysis; miR-137; Schizophrenia; Single nucleotide polymorphism

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M.L. Ou; G. Liu; D. Xiao; B.H. Zhang; C.C. Guo; X.G. Ye; Y. Liu; N. Zhang; M. Wang; Y.J. Han; X.H. Ye; C.X. Jing; G. Yang; M.L. Ou; G. Liu; D. Xiao; B.H. Zhang; C.C. Guo; X.G. Ye; Y. Liu; N. Zhang; M. Wang; Y.J. Han; X.H. Ye; C.X. Jing; G. Yang
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Biochemical markers; Genetic polymorphisms; Oxidative stress; Schizophrenia

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Schizophrenia is considered one of the most severe and complex mental disorders; it affects both the quality of life of the patient and his family. The dopamine hypothesis is the main concept concerning antipsychotic activity. Patients with treatment-refractory schizophrenia have a lower capacity for dopamine synthesis than those with a good response to first- ... more

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Hypertensive cerebellar hemorrhage; Rehabilitative treatment; Single nucleotide polymorphisms; Vascular endothelial growth factor

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We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were detected by DNA ... more

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Nuclear factor-kB; Ovarian cancer; Single nucleotide polymorphisms

Nuclear factor-κB (NF-κB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-κB gene family) is associated with increased risk of various cancers. However, only one study has reported that rs28362491 ... more

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Bronchiolitis; Chinese population; ORMDL3 gene; Respiratory viruses; Single nucleotide polymorphisms

Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibility/viral findings among ... more

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Chronic obstructive pulmonary disease; Hypoxia-inducible factor-1α; Single nucleotide polymorphisms

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