Research Article

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08/02/2023
GWAS; Lasiodiplodia theobromae; Mangifera indica; Neofusicoccum parvum; PLINK; Tassel

Lasiodiplodia theobromae and Neofusicoccum parvum are important fungi affecting mango trees in Northeast Brazil, a prominent region of mango export.  Genome-wide association studies in a ‘Haden’ × ‘Tommy Atkins’ mango pseudo-F2 population were performed for symptoms of both fungal diseases to support the development of new cultivars by ... more

C.A.F. Santos; D.A.L. Aquino; D.C. Batista; E.O.S. Alves
09/21/2015
c-Jun N-terminal kinases; CAAT/enhanced I-binding protein; Endoplasmic reticulum stress; Hypertension; Ischemia/reperfusion

Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain ischemia was induced by 4- ... more

Y.N. Zhao; J.M. Li; C.X. Chen; P. Zhang; S.X. Li
08/21/2015
Haplotype; Hypertension; Mongolian; SLC12A3; TagSNP

Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype ... more

J.Q. Liang; Y.G. Xi; C.Y. An; X.L. Su
12/22/2015
Hypertension; Mitochondria; Mitochondrial tRNA mutations; Pathogenic mutations

Mutations in mitochondrial DNA have been found to be associated with hypertension. Of these, mitochondrial transfer RNA (mt-tRNA) is a hot spot for these pathogenic mutations. It is generally believed that these mutations may result in the failure of mt-tRNA metabolism, thereby worsening mitochondrial dysfunction and resulting in hypertension. mt-tRNA is known for its high frequency of ... more

S.L. Yin; C. Lan; H. Pei; Z.Q. Zhu
12/01/2015
Hypertension; klotho gene; Single nucleotide polymorphism

The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We included 710 participants aged 93.5 ± 3.2 years in the analyses. The ... more

L.L. Gao; X. Ding; D.M. Xie; M. Yang; B.R. Dong
11/26/2015
CYP4F2; Gene polymorphism; Hypertension; Meta-analysis

Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the CYP4F2 gene rs2108622 polymorphism and ... more

X.H. Luo; G.R. Li; H.Y. Li
01/22/2016
Calcium/calmodulin-dependent kinase 4; CAMK4; Hypertension; rs10491334

Considering that calcium/calmodulin-dependent kinase 4 (CAMK4) plays a pivotal role in blood pressure regulation, we investigated the association between a CAMK4 polymorphism (rs10491334) and hypertension in the Han, Kazak, and Uygur ethnic groups. We studied 1224 patients with hypertension and 967 normotensive controls classified into three ethnic groups (Han, Kazak, and Uygur ... more

S.Z. Chen; Z. Wang; L.N. Zhang; G.L. Lu; C.M. Zhou; D.W. Wang; Z.M. Tang; L. Wang; L. Qin; Z.H. Zhai; S.Z. Chen; Z. Wang; L.N. Zhang; G.L. Lu; C.M. Zhou; D.W. Wang; Z.M. Tang; L. Wang; L. Qin; Z.H. Zhai; S.Z. Chen; Z. Wang; L.N. Zhang; G.L. Lu; C.M. Zhou; D.W. Wang; Z.M. Tang; L. Wang; L. Qin; Z.H. Zhai
07/06/2017
Aged; Case-control studies; China; Endothelin-1; Female; Gene frequency; Humans; Hypertension; male; Middle Aged; Mutation, Missense; Polymorphism, Single Nucleotide

Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, two single nucleotide polymorphisms in EDN1 have been reported to be ... more

Z. Fang; M. Li; Z. Ma; G. Tu
02/25/2019
Atherosclerosis; eNOS; GSTM1; GSTT1; Hypertension

Atherosclerosis is a multifactorial chronic inflammatory disease that occurs in response to endothelial aggression. Systemic arterial hypertension is the main risk factor for the formation of atheromas, increasing the risk of cardiovascular diseases. Several genes are involved in atherogenesis and hypertension. We analyzed polymorphisms of candidate genes that ... more

M.P. Moraes; K.S.Fe Silva; M.H. Lagares; A.M. Barbosa; J.V.M. Martins; F.L. Campedelli; I.R. da Costa; D.A. Rodrigues; K.K.V.O. Moura
07/18/2019
Atherosclerosis; Diabetes; Dyslipidemia; eNOS; Hypertension

Atherosclerosis is a chronic multifactorial inflammatory disease that evolves in response to aggression of the endothelium, causing plaque formation in large or medium-sized arteries. Various co-factors can accelerate the evolution of this pathology, such as systemic arterial hypertension, dyslipidemia and diabetes mellitus. Given that nitrous oxide is a potent ... more

F.R.B. Oliveira; J.F. Corrêa; K.S.F. Silva; I.A. Costa; R.S. Mascarenhas; A.M. Barbosa; M.H. Lagares; F.L. Campedelli; K.K.V.O. Moura

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