Research Article

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07/06/2015
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Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion ... more

Z.T. Wang; H.Y. Gong; F. Zheng; D.J. Liu; T.L. Dong
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MicroRNA; miR-494; Pancreatic cancer; Prognosis; Survival

MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the ... more

Y.B. Ma; G.X. Li; J.X. Hu; X. Liu; B.M. Shi
12/17/2015
Meta-analysis; NAT2; Pancreatic cancer; Polymorphism; susceptibility

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to assess this relationship ... more

J.X. Liang; W. Gao; Y. Liang; X.M. Zhou
12/09/2015
MicroRNA-218; Pancreatic cancer; Prognosis

microRNA-218 (miR-218) is a vertebrate-specific miRNA that plays a crucial role in tumorigenesis and tumor progression. This study analyzed the miR-218 expression level and clinical significance in pancreatic cancer. One hundred and seven pairs of pancreatic cancer and adjacent normal tissues were analyzed by quantitative reverse-transcriptase polymerase chain reaction. The correlation between ... more

B.S. Li; H. Liu; W.L. Yang
12/08/2015
Cancer invasion; MicroRNA-215; Pancreatic cancer; Proliferation Prognosis

It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. However, its expression and function in pancreatic cancer is still unclear. The aim of this study was to explore the effects of miR-215 on pancreatic cancer formation and progression. Using quantitative RT-PCR, we detected miR-215 expression in pancreatic ... more

Q.W. Li; T. Zhou; F. Wang; M. Jiang; C.B. Liu; K.R. Zhang; Q. Zhou; Z. Tian; K.W. Hu
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Gemcitabine; Pancreatic cancer; Radiosensitization; Radiotherapy

The aim of this study was to evaluate the radiosensitizing effects of gemcitabine towards human pancreatic cancer xenografts. A human pancreatic cancer xenograft model was established in nude mice, 36 of which were randomly divided into 6 treatment groups. Tumors were measured every 2 days, and the tumor volumes, growth delays, and inhibition rates were compared to evaluate the ... more

Z.T. Shen; X.H. Wu; L. Wang; B. Li; X.X. Zhu
03/18/2016
ERCC1-ERCC5; Pancreatic cancer; Polymorphism

We conducted a case-control study to investigate the role of ERCC1-ERCC5 gene polymorphisms in the risk of pancreatic cancer. This study included 195 patients who were newly diagnosed with histopathologically confirmed primary pancreatic cancer, and 254 controls were recruited from Sir Run Run Shaw Hospital, between January 2012 and December 2014. Genotyping of ERCC1 rs3212986 and ... more

M.F. Ying; R. Zhao; M.F. Ying; R. Zhao; M.F. Ying; R. Zhao
09/28/2015
Enriched library; Microsatellite markers; Polymorphism; Sika deer

Microsatellite markers are widely and evenly distributed, and are highly polymorphic. Rapid and convenient detection through automated analysis means that microsatellite markers are widely used in the construction of plant and animal genetic maps, in quantitative trait loci localization, marker-assisted selection, identification of genetic relationships, and genetic diversity and phylogenetic ... more

Y.M. Li; C.Y. Bai; W.P. Niu; H. Yu; R.J. Yang; S.Q. Yan; J.Y. Zhang; M.J. Zhang; Z.H. Zhao
08/21/2015
Chinese Hui population; Polymorphism; TCF7L2; Type 2 diabetes mellitus

Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated ... more

Y. Yang; J.R. Xu; Y.J. Wang; X.M. Liu
08/14/2015
Large yellow croaker; Larimichthys crocea; Microsatellites; Polymorphism

The large yellow croaker (Larimichthys crocea) is one of the largest marine net-cage cultured species in the oceans around China. In the present study, we isolated and characterized 13 polymorphic microsatellite markers from genomic libraries of L. crocea. Loci were screened for 10 wild specimens from 2 sites in southeast of China. All loci were polymorphic. The number of ... more

X.Q. Wang; D. Zeng; X. Ma; G. Xiong; Z.Y. Wang; T. Sakamoto

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