Case Report

Related GMR Articles

ASB15 gene; Chicken; Growth and carcass traits; Single nucleotide polymorphism

ASB15 is a member of the ankyrin repeat and suppressor of cytokine signaling box family, and is predominantly expressed in skeletal muscle. In the present study, an F2 resource population of Gushi chickens crossed with Anka broilers was used to investigate the genetic effects of the chicken ASB15 gene. Two single nucleotide polymorphisms (SNPs) (rs315759231 A>G and ... more

Y.C. Wang; R.R. Jiang; X.T. Kang; Z.J. Li; R.L. Han; J. Geng; J.X. Fu; J.F. Wang; J.P. Wu
Chemotherapy; ERCC1; ERCC2; Osteosarcoma; Overall survival; Single nucleotide polymorphism

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess ... more

Q. Zhang; L.Y. Lv; B.J. Li; J. Zhang; F. Wei
Cardiac troponin T type-2 gene; Dilated cardiomyopathy; Gene mutation; Nuclear lamina protein gene; Single nucleotide polymorphism; Tropomyosin gene

Dilated cardiomyopathy (DCM) is a myocardial disease with a high mortality rate. Approximately 40 genes have been found to be associated with DCM to date. Non-familial DCM can also be caused by gene mutations, suggesting that genetic factors were involved in the pathogenesis of DCM; therefore genetic testing is beneficial for the early diagnosis of DCM, which can facilitate the ... more

Y.D. Li; Y.T. Ji; X.H. Zhou; H.L. Li; H.T. Zhang; Y. Zhang; J.X. Li; Q. Xing; J.H. Zhang; Y.F. Hong; B.P. Tang
3'-UTR; Coronary artery disease; Gene; MEF2A; Single nucleotide polymorphism

Association of variants in the myocyte enhancer factor 2A (MEF2A) gene and the risk of coronary artery disease (CAD) has drawn much attention but remains controversial. We hypothesized that the 3'-untranslated region (3'-UTR) of this gene could harbor functionally relevant nucleotide changes. Here, we assessed the association between single nucleotide polymorphisms (SNPs) in the ... more

X.C. Huang; W. Wang
Benign prostatic hyperplasia; Interleukin-28B; Interleukin-28B receptor α; Lower urinary tract symptoms; Single nucleotide polymorphism

The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917, and IL-28Rα rs10903035 and ... more

L. .Xiao; L.B. Gao; Q. Wei
Han people; Ischemic stroke; Mongol; Phosphodiesterase 4D gene; Single nucleotide polymorphism

We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Han patients) were detected ... more

J.P. Shi; W.D. Chen; J.Q. Zhou; M.M. Xue; F. Xue; H.Z. Li; Z.P. Xu
Body measurement trait; CIDEC; Meat quality trait; Qinchuan cattle; Single nucleotide polymorphism

Previous studies have shown that the cell death-inducing DFF45-like effector-C (CIDEC) gene is involved in lipid storage and energy metabolism, suggesting that it is a potential candidate gene that affects body measurement traits (BMTs) and meat quality traits (MQTs). The aim of this study was to identify polymorphisms of the bovine CIDEC gene and analyze their possible ... more

C.G. Mei; L.S. Gui; C.Z. Fu; H.C. Wang; J.L. Wang; G. Cheng; L.S. Zan
Body mass index; Genetic variant; Obesity; PCSK1 gene; POMC gene; Single nucleotide polymorphism

Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood. This family-based study analyzed the links between single nucleotide polymorphisms (SNPs) in either the POMC or PCSK1 genes and obesity, as well as obesity-related traits among obese Thai children and their families. The variants rs1042571 ... more

S. Kulanuwat; J. Santiprabhob; B. Phonrat; C. Limwongse; A. Tungtrongchitr; N. Chongviriyaphan; R. Tungtrongchitr
Growth arrest and DNA-damage-inducible protein 45 alpha gene; meat quality; Pig; Single nucleotide polymorphism

This study was conducted to evaluate the porcine gene GADD45A (growth arrest and DNA-damage-inducible protein 45 alpha) as a positional candidate controlling quantitative trait loci (QTL) for meat quality traits on chromosome 6 (SSC6). Four exons of the porcine GADD45A gene were defined from cDNA and BAC clone sequences. A total of 4 single nucleotide ... more

E.S. Cho; K.T. Lee; J.W. Choi; H.J. Jeon; S.W. Lee; Y.M. Cho; T.H. Kim
Methionine synthase reductase; Methylene tetrahydrofolate reductase; Recurrent miscarriages; Single nucleotide polymorphism

We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes. A case control study was conducted in 118 patients with unexplained recurrent spontaneous abortion (abortion group) and 174 healthy women (control group). The genetic ... more

L. Zhu