Research Article

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12/28/2015
Genetic relationship; PCR; Polymorphism; RAPD

The artichoke (Cynara scolymus L.) is an important food and medicinal crop that is cultivated in Mediterranean countries. Morphological characteristics, such as head shape and diameter, leaf shape, and bract shape, are mainly affected by environmental conditions. A molecular marker approach was used to analyze the degree of polymorphism between artichoke hybrid lines. The degree ... more

M.A. Sharaf-Eldin; A. Al-Tamimi; P. Alam; S.F. Elkholy; J.R. Jordan
12/22/2015
Inflammation; Interleukin-10; Periodontal disease; Polymorphism

Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated ... more

R. Hannum; F.R. Godoy; A.S. da Cruz; T.C. Vieira; L.B. Minasi; deM. e Silva; C.C. da Silva; A.D. da Cruz
12/21/2015
Abdominal aortic aneurysm; Interleukin-10; Polymorphism

In this case-control study, we attempted to investigate the role of three common single nucleotide polymorphisms (SNPs; -1082G/A rs1800896, -819T/C rs1800871, and -592A/C rs1800872) in the IL-10 gene in the development of abdominal aortic aneurysm in a Chinese population. Three hundred and eighty-one patients with abdominal aortic aneurysm and age- and gender-matched healthy ... more

F. Wang; Q.Q. Quan; C.L. Zhang; Y.B. Li; T.B. Jiang
12/17/2015
Meta-analysis; Polymorphism; Tumor necrosis factor-α; Vitiligo

Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the ... more

G. Nie; J.H. Qi; C.W. Huang; T. Yang; N. Shi; Y.J. Chen
12/17/2015
Meta-analysis; NAT2; Pancreatic cancer; Polymorphism; susceptibility

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to assess this relationship ... more

J.X. Liang; W. Gao; Y. Liang; X.M. Zhou
12/14/2015
Meta-analysis; Polymorphism; rs7903146; T2DM; TCF7L2

Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for evidence-based ... more

X.H. Liu; C.G. Xie; Y. An; X.X. Zhang; W.B. Wu
12/09/2015
NLRP3; Polymorphism; Primary gout

We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain ... more

L.F. Wang; Y.J. Ding; Q. Zhao; X.L. Zhang
12/08/2015
Genotype; Goat; Milk protein; Polymorphism; SDS-PAGE

This study evaluates the relationship between the genotype and milk protein components in goats. Milk samples were collected from cloned goats and normal white goats during different postpartum (or abortion) phases. Two cloned goats, originated from the same somatic line of goat mammary gland epithelial cells, and three sexually reproduced normal white goats with no genetic relationships ... more

H. Xing; B. Shao; Y.Y. Gu; Y.G. Yuan; T. Zhang; J. Zang; Y. Cheng
12/02/2015
Case-control study; Crohn’s disease; Meta-analysis; Polymorphism; Tumor necrosis factor-α

We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn’s disease (CD) using a meta-analysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search in October 2014) were comprehensively searched for relevant ... more

Y.Q. Mao; S.Q. Dong; M. Gao
12/03/2015
Acute pancreatitis; Interleukin-10; Polymorphism

We conducted a case-control study to investigate the possible association between three common single nucleotide polymorphisms in interleukin-10 (IL-10) and the development of acute pancreatitis in a Chinese population. Between January 2013 and December 2014, 255 patients with acute pancreatitis and 255 control subjects were recruited for the study. Genotyping of IL-10 rs1800896, ... more

H.L. Jia; P.L. Sun; C.Q. Lu

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