Research Article

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12/11/2015
Breast cancer; Chemotherapy; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment ... more

P. Yuan; L. Yuan; B.L. Xu; C.Z. Wang; H.Z. Yang; Y. Li
09/22/2015
Chemotherapy; Clinical outcome; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, ... more

J. Wang; T. Wang; G.Y. Yin; L. Yang; Z.G. Wang; X.B. Bu
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Breast cancer; S-phase kinase-associated protein 2; siRNA interference; SKP2

We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2 in breast cancer patient ... more

Y.J. Sun; X.K. Wang; B.J. Li
12/14/2015
Breast cancer; KRAS; let-7; Polymorphism

Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, ... more

X. Huang; Y. Yang; Y. Guo; Z.L. Cao; Z.W. Cui; T.C. Hu; L.B. Gao
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Breast cancer; MTHFR; Polymorphism; Risk

We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length ... more

X.F. Zhang; T. Liu; Y. Li; S. Li
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Angiotensin II type-1 receptor; Breast cancer; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensin II type-1 receptor (AGTR1) gene A1166C polymorphism and breast cancer risk. However, the specific association is controversial. The aim of the present study was to derive a more precise estimation of the relationship. A comprehensive research was conducted of the PubMed and the Google Scholar databases through ... more

L. Li; F. Wang; P.W. Lv; M.Z. Zhu; J.J. He; G.C. Guo; Y.T. Gu; M.L. Han
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Genetic polymorphism; Glioma; Glutathione S-transferases; Perillyl alcohol

GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine whether ... more

M.M. Silva; C.O. Da Fonseca; R. Moura-Neto; J.F. Carvalho; T. Quirico-Santos; M.G. Carvalho
04/25/2014
ATP-binding cassette; Clinical outcome; Glutathione S-transferases; Osteosarcoma

We conducted a comprehensive study to investigate the role of genes involved in metabolic and transport pathways in response to chemotherapy and clinical outcome of osteosarcoma patients. Genotyping of seven gene polymorphisms was performed on a 384-well plate format on the Sequenom MassARRAY platform in 162 patients with osteosarcoma. We studied the correlation of the seven gene ... more

J.Z. Li; Z.Q. Tian; S.N. Jiang; T. Feng
06/11/2015
Breast cancer; Ethnicity; Glutathione S-transferases; Northeastern Mexico; Polymorphisms

Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The purpose of this study was to ... more

G. Jaramillo-Rangel; M. Ortega-Martínez; R.M. Cerda-Flores; H.A. Barrera-Saldaña
09/21/2015
Breast cancer; GIT2; Metastasis; MTERF; Multiplex RT-PCR

Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive markers for metastatic risk. This multiplex ... more

S. Sirirattanakul; P. Wannakrairot; T. Tencomnao; R. Santiyanont

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