Research Article

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This study investigated the correlation of plama levels of inflammatory biomarkers [soluble cluster of differentiation 40 ligand (sCD40L), alpha fetoprotein A (fetuin-A), and pregnancy-associated protein A (PAPP-A)] with carotid plaque in patients with acute ischemic stroke. After undergoing color Doppler ultrasonography of the bilateral carotid arteries, 200 patients with acute ischemic ... more

Y.J. Wang; Z.Q. Gong; X.M. Bi; Y.L. Li
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Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were ... more

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IL10 -1082A/G; IL10 -592C/A; Ischemic stroke; Polymorphism

We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms were investigated ... more

W.Z. Li; C.Y. Gao; W.L. He; H.M. Zhang; W.Z. Li; C.Y. Gao; W.L. He; H.M. Zhang; W.Z. Li; C.Y. Gao; W.L. He; H.M. Zhang
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Hemorrhagic stroke; Ischemic cerebrovascular accident; Ischemic stroke; Risk factors analysis; Stroke risk factors

Stroke is one of the leading causes of death both globally and in Southeast Asia, which is confirmed by high values: 5 million and 500 thousand deaths annually, respectively. The situation in Vietnam is also critical. We have systematized and studied the risk factors in patients with ischemic stroke in Phu Tho Province General Hospital. This was a prospective ... more

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ASB15 gene; Chicken; Growth and carcass traits; Single nucleotide polymorphism

ASB15 is a member of the ankyrin repeat and suppressor of cytokine signaling box family, and is predominantly expressed in skeletal muscle. In the present study, an F2 resource population of Gushi chickens crossed with Anka broilers was used to investigate the genetic effects of the chicken ASB15 gene. Two single nucleotide polymorphisms (SNPs) (rs315759231 A>G and ... more

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Chemotherapy; ERCC1; ERCC2; Osteosarcoma; Overall survival; Single nucleotide polymorphism

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess ... more

Q. Zhang; L.Y. Lv; B.J. Li; J. Zhang; F. Wei
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Cardiac troponin T type-2 gene; Dilated cardiomyopathy; Gene mutation; Nuclear lamina protein gene; Single nucleotide polymorphism; Tropomyosin gene

Dilated cardiomyopathy (DCM) is a myocardial disease with a high mortality rate. Approximately 40 genes have been found to be associated with DCM to date. Non-familial DCM can also be caused by gene mutations, suggesting that genetic factors were involved in the pathogenesis of DCM; therefore genetic testing is beneficial for the early diagnosis of DCM, which can facilitate the ... more

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09/21/2015
3'-UTR; Coronary artery disease; Gene; MEF2A; Single nucleotide polymorphism

Association of variants in the myocyte enhancer factor 2A (MEF2A) gene and the risk of coronary artery disease (CAD) has drawn much attention but remains controversial. We hypothesized that the 3'-untranslated region (3'-UTR) of this gene could harbor functionally relevant nucleotide changes. Here, we assessed the association between single nucleotide polymorphisms (SNPs) in the ... more

X.C. Huang; W. Wang
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Benign prostatic hyperplasia; Interleukin-28B; Interleukin-28B receptor α; Lower urinary tract symptoms; Single nucleotide polymorphism

The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917, and IL-28Rα rs10903035 and ... more

L. .Xiao; L.B. Gao; Q. Wei
08/19/2015
Gout; Metabolic indices; Single nucleotide polymorphism; SLC2A9; ZNF518B

Current evidence suggests that heredity and metabolic syndrome contribute to gout progression. SLC2A9 and ZNF518B may play a role in gout progression in different populations, but no studies have focused on the Tibetan Chinese population. In this study, we determined whether variations in these 2 genes were correlated with gout-related indices in Chinese-Tibetan gout ... more

X.Y. Zhang; T.T. Geng; L.J. Liu; D.Y. Yuan; T. Feng; L.L. Kang; T.B. Jin; C. Chen

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