Research Article

Related GMR Articles

Beef cattle; Bos indicus; Carcass traits; Single nucleotide polymorphisms; Tenderness

Data from purebred Brahman steers (N = 467) were used to study the association of single nucleotide polymorphisms (SNP) with carcass traits and measures of tenderness. Fall weaned calves were grazed and fed in a subtropical environment and then harvested for processing in a commercial facility. Carcass data were recorded 24 h postmortem. Muscle samples and primal ribs were obtained to measure ... more

T. Smith; M.G. Thomas; T.D. Bidner; J.C. Paschal; D.E. Franke
Major histocompatibility complex; Poultry; Single nucleotide polymorphisms; TAP1; TAP2

TAP1 and TAP2 genes code for the two subunits of the transporter associated with antigen processing (TAP), and in chicken they are located between the two MHC class I genes. Using primers based on chicken sequences, the genomic regions corresponding to chicken TAP1 exons 6 to 7 and TAP2 exons 4 to 6 (which encode portions of the chicken TAP1 and ... more

L. Sironi; B. Lazzari; P. Ramelli; A. Stella; P. Mariani
Biological control; Differential display reverse transcriptase; Expressed sequence tag; Nematophagous; Single nucleotide polymorphisms

The technology of mRNA-based differential display reverse transcriptase-polymerase chain reaction (DDRT-PCR) was used to detect a 246-bp differentially expressed fragment from the nematophagous fungus Arthrobotrys oviformis when young mycelia were induced with the round worm Haemonchus contortus. The fragment was converted into an expressed sequence tag (EST) through ... more

A. Nagee; A. Acharya; A. Shete; P.N. Mukhopadhyaya; B.A. Aich
Arabidopsis disease resistance genes; Arachis; genetic mapping; Molecular markers; Single nucleotide polymorphisms

The cultivated peanut (Arachis hypogaea L.) is an allotetraploid of recent origin, with an AABB genome and low genetic diversity. Perhaps because of its limited genetic diversity, this species lacks resistance to a number of important pests and diseases. In contrast, wild species of Arachis are genetically diverse and are rich sources of disease resistance genes. Consequently ... more

D.M.T. Alves; R.W. Pereira; S.C.M. Leal-Bertioli; M.C. Moretzsohn; P.M. Guimarães; D.J. Bertioli
AGER; Genetic polymorphisms; Gestational diabetes; RAGE; Single nucleotide polymorphisms

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, ... more

I.C.R. Santos; D.R. Daga; H.R. Frigeri; R.R. Réa; A.C.R. Almeida; E.M. Souza; F.O. Pedrosa; C.M.T. Fadel-Picheth; G. Picheth
BRCA1-interacting protein-terminal helicase 1; Breast cancer; Single nucleotide polymorphisms

BRCA1-interacting protein C-terminal helicase 1 (BRIP1) is a DNA helicase that influences the DNA repair ability and tumor suppressor function of BRCA1. Truncating BRIP1 mutations have been described as cancer susceptibility alleles. To evaluate BRIP1 polymorphisms as risk factors for breast cancer, we performed a detailed analysis of possible single nucleotide ... more

L.P. Ren; Y.S. Xian; D.M. Diao; Y. Chen; Q. Guo; C.X. Dang
Association analysis; Bone mineral density; Osteoporosis; Osteoprotegerin gene; Postmenopausal women; Single nucleotide polymorphisms

Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs ... more

J.F. Song; Z.Z. Jing; W. Hu; Y.X. Su
CYP2C8; Cytochrome P450; Pharmacogenetics; Single nucleotide polymorphisms

CYP2C8 is an important member of the cytochrome P450 family of enzymes; it affects the activity of various drugs used in routine clinical practice, including amiodarone, chloroquine, amodiaquine, and repaglinide, as well as endogenous compounds, such as arachidonic acid and retonic acid. It is also the main enzyme involved in the metabolism of the widely used anticancer drug Paclitaxel, ... more

S. Minhas; N. Setia; S. Pandita; R. Saxena; I.C. Verma; S. Aggarwal
CD86; CTLA-4; Rheumatoid arthritis; Single nucleotide polymorphisms

The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We ... more

C.P. Liu; J.A. Jiang; T. Wang; X.M. Liu; L. Gao; R.R. Zhu; Y. Shen; M. Wu; T. Xu; X.G. Zhang
Chicken; Economic traits; Growth and meat quality association; HMGCR gene; Single nucleotide polymorphisms

The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is rate-limiting for metabolism of cholesterol; it plays an important role in endogenous cholesterol biosynthesis. We used DNA sequencing technology and created restriction site PCR-RFLP to detect HMGCR SNPs in an F2 resource population of Gushi chicken and Anka broilers. We found a G/T mutation (Gln/ ... more

Y. Wei; S.K. Zhu; S. Zhang; R.L. Han; Y.D. Tian; G.R. Sun; X.T. Kang