Research Article

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05/11/2015
Meat quality traits; Polymorphisms; Qinchuan cattle

Here, we detected 2 SNPs, A85C and T335C, that were located on the 3rd exon and the 3 untranslated regions of the bovine Osteocrin gene, respectively, using 413 Qinchuan cattle DNA samples. PCR-SSCP and DNA sequencing methods were specifically used. Three genotypes (AA, AC, and CC) were found at A85C; yet, only 2 genotypes (TC and CC) were found at T335C. Association analysis showed that ... more

Y.F. Huangfu; L.S. Zan; C. Adoligbe; H.B. Wang; H. Wang; J.B. Gao
04/13/2015
Ethnic; Infectious disease; Interleukin-10; Interleukin-12B; Malaysia; Polymorphisms

Inheritance of polymorphisms in the interleukin (IL)-10 promoter and IL-12B genes, which influence cytokine production and activities, may define the balance in T helper response in infection and autoimmune diseases. In the present study, we investigated the distribution of the IL-10 promoter and IL-12B gene polymorphisms in a multiethnic Malaysian population. Overall, ... more

S.S. Sam; B.T. Teoh; S. AbuBakar
03/31/2015
Amerindian; Ethnicity; Mexican Mestizo population; MMP-9; Polymorphisms; Population genetics

We studied the interethnic variation of the MMP-9 microsatellite in the Mestizo and Amerindian populations using blood samples collected from 435 healthy unrelated individuals from the Central Valley of Mexico. DNA samples were genotyped using the -90 (CA)12-27 repeat near the MMP transcriptional start site using capillary electrophoresis. Our data were ... more

R. Camacho-Mejorado; G. Noris; C. Santana; J.J. Magaña; A. Majluf-Cruz; J. Arellano-Galindo; A. De la Peña; J. Hernández-Juárez; E.S. Calderón-Aranda; M.A. Meraz-Ríos; R. Gómez
03/20/2015
HBV; Hepatocellular carcinoma; MicroRNA; Polymorphisms

We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were genotyped by polymerase chain ... more

D. Li; J.J. Peng; Y. Tan; T. Chen; D. Wei; M. Du; T. Zhang
03/13/2015
Diabetic nephropathy; INSR; mTOR; Polymorphisms; Type 2 diabetes mellitus

We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom ... more

A.N. Zhu; X.X. Yang; M.Y. Sun; Z.X. Zhang; M. Li
02/13/2015
ABCB1; Breast cancer; MDR1; Polymorphisms; Pre- and postmenopausal women

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between ... more

S.A. Gutiérrez-Rubio; A. Quintero-Ramos; A. Durán-Cárdenas; R.A. Franco-Topete; J.M. Castro-Cervantes; A. Oceguera-Villanueva; L.M. Jiménez-Pérez; L.M.A. Balderas-Peña; G. Morgan-Villela; A. Del-Toro-Arreola; A. Daneri-Navarro
02/06/2015
ASIP; Coat color; Copy number variation; Polymorphisms

Tibetan sheep, an indigenous breed, have a wide variety of phenotypes and a colorful coat, which make this breed an interesting model for evaluating the effects of coat-color gene mutations on this phenotypic trait. The agouti signaling protein (ASIP) gene is a positional candidate gene, as was inferred based on previous study. In our research, ASIP gene copy numbers in ... more

J.L. Han; M. Yang; Y.J. Yue; T.T. Guo; J.B. Liu; C.E. Niu; B.H. Yang
01/15/2015
Autoimmune polyglandular syndrome type III; Fyn-binding protein; Polymorphisms; T1DM

The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. We also assessed the role of FYB SNPs in the insurgence of autoimmune polyglandular syndrome type III (APSIII), characterized by the simultaneous presence of autoimmune ... more

C.J.C. Addobbati; deAzevêdo Silva; N.A.C. Tavares; J. Araújo; R.L. Guimarães; L. Brandão; S. Crovella; P. Sandrin-Garcia
07/21/2009
Animal breeding; DNA sequencing; Double muscling; Meat production; Single nucleotide polymorphisms

The myostatin gene, also known as GDF8 (growth dif­ferentiation factor 8), is located on bovine chromosome 2 (BTA2); it has three exons and two introns. Myostatin is specifically expressed during embryonic development and in adult skeletal muscle, func­tioning as a negative regulatory protein. Several cattle breeds (Pied­montese, Belgian Blue and Blond’Aquitaine, and others) show poly­ ... more

A.B. Grisolia; G.T. D’Angelo; L.R.Porto Neto; F. Siqueira; J.F. Garcia
07/14/2009
Bioinformatics; Expressed sequence tags; Single nucleotide polymorphisms; Witches’ broom disease

In order to increase the efficiency of cacao tree resistance to witches’ broom disease, which is caused by Moniliophthora perniciosa (Tricholomataceae), we looked for molecular markers that could help in the selection of resistant cacao genotypes. Among the different markers useful for developing marker-assisted selection, single nucleotide polymorphisms (SNPs) constitute the ... more

L.S. Lima; K.P. Gramacho; N. Carels; R. Novais; F.A. Gaiotto; U.V. Lopes; A.S. Gesteira; H.A. Zaidan; J.C.M. Cascardo; J.L. Pires; F. Micheli

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