Research Article

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12/21/2005
Breast cancer; Polymorphisms; RAD51-G135C; XPD-Lys751Gln; XRCC1-Arg399Gln; XRCC3-Thr241Met

Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an increased risk of cancer. Polymorphisms have been ... more

R.Mucha Dufloth; S. Costa; F. Schmitt; L.Carlos Zeferino
12/01/2009
Childhood acute lymphoblastic leukemia; Haplotypes; Mexicans; Polymorphisms; XRCC1

We examined the influence of the Arg194Trp, Arg280His, and Arg399Gln polymorphisms of XRCC1 (X-ray repair cross-complementing group 1) on the development of childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients and 120 controls in Mexico. All of them were genotyped for these polymorphisms, using polymerase chain reaction. No significant differences in allele and ... more

J.P. Meza-Espinoza; V. Peralta-Leal; M. Gutierrez-Angulo; N. Macias-Gomez; M.L. Ayala-Madrigal; P. Barros-Nuñez; J. Duran-Gonzalez; E. Leal-Ugarte
07/01/2008
Breast cancer; estrogen; Hereditary disease; Polymorphisms

The association of tumor differentiation and estrogen receptor expression with the prognosis of breast cancer has been well established. Nevertheless, little is yet reported about the association of morphological characteristics of the tumor, estrogen receptor status and polymorphisms in low penetrance genes. The aim of the present study was to investigate a possible association between DNA ... more

R.M. Dufloth; A. Arruda; J.K.R. Heinrich; F. Schmitt; L.C. Zeferino
01/08/2008
Allele specific polymerase chain reaction; Mexican populations; Orosomucoid; Polymorphisms; Sequencing; Teenek Amerindians

The human orosomucoid 1 gene (ORM1) codes an alpha-1-acid glycoprotein that has been classified as an acute-phase reactive protein, and a major drug-binding serum component, as well as an immunomodulatory protein with genetic polymorphisms. Evaluation of ORM variation through isoelectric focusing and immunobloting has revealed a world-wide distribution of the ORM1 F and ORM1 S alleles. We ... more

L. García-Ortiz; G. Vargas-Alarcón; J.M. Fragoso; J. Granados; M. Noriega; N. Pérez; H. Reyes; J.C. Zenteno-Ruiz; E. Martínez-Cordero
12/19/2011
hOGG1; Oxidative stress; Polymorphisms; XPD

Knee replacement surgery is an ischemia/reperfusion model, as it uses tourniquet applied to the knee area to stop the blood flow during the operation. Fifty patients that were undergoing elective arthroscopic knee surgery were included in our study. Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. XPD ... more

O. İsbir; U. Gormus; H.A. Ergen; B. Cakmakoglu; Ö.T. Kahraman; N. Baykan
11/04/2011
Body measurement traits; Cattle; MyoG; Polymorphisms

Using PCR-SSCP and DNA sequencing technology, we examined the association of single nucleotide polymorphisms (SNPs) in the bovine MyoG gene with body measurement traits in 779 individuals of six native Chinese cattle breeds, namely Luxi, Luxi × Simmental crossbred, Nanyang, Xia’nan, Jiaxian red, and Qinchuan. A novel SNP, T314C, was detected. Allelic frequencies of MyoG- ... more

M. Xue; L.S. Zan; L. Gao; H.B. Wang
11/04/2011
Albuminuria; Essential hypertension; Lectin-like oxidized low-density lipoprotein receptor 1; Polymorphisms

Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have now investigated a possible association between OLR-1 polymorphisms ... more

X.W. Hou; Z.H. Hu; Y. Cui; W. Gao; S.P. Sun; N.F. Wang
10/25/2011
Congenital heart defect; Folic acid; Homocysteine; Methionine synthase reductase; Polymorphisms

Congenital heart defects (CHDs) are the most common birth defects; genes involved in homocysteine/folate metabolism may play important roles in CHDs. Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine. We investigated whether two polymorphisms (A66G and C524T) of the MTRR gene are associated with ... more

W. Zeng; L. Liu; Y. Tong; H.M. Liu; L. Dai; M. Mao
10/13/2011
Cashmere fiber traits; Cashmere goats; Polymorphisms; Prolactin receptor

The most important traits of Chinese Liaoning cashmere goat fiber are fiber diameter, weight, and length. We looked for polymorphisms and their possible association with cashmere fiber traits in the 5' upstream region (5' UTR) of the prolactin receptor gene (PRLR), which encodes an anterior pituitary peptide hormone involved in different physiological activities; it is the ... more

J.P. Zhou; X.P. Zhu; W. Zhang; F. Qin; S.W. Zhang; Z.H. Jia
08/26/2011
Non-small cell lung cancer; Polymorphisms; STAT3

Signal transducer and activator of transcription protein 3 (STAT3) has been implicated in cancer development and is recognized as a type of oncogene. However, association studies of single nucleotide polymorphisms (SNPs) in the STAT3 gene with cancer risk are rare and not available for lung cancer. We examined whether STAT3 polymorphisms are associated with the risk of ... more

B. Jiang; Z.Z. Zhu; F. Liu; L.J. Yang; W.Y. Zhang; H.H. Yuan; J.G. Wang; X.H. Hu; G. Huang

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