Research Article

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We aimed to investigate the influence of lentiviral-medi­ated Bcl-2 overexpression in cerebral tissues of rats with acute cerebral infarction. Forty-five rats were randomly divided into sham, model, and treatment groups. The sham and model groups were administered a control lentiviral vector via the intracranial arteries 10 days before surgery, while the treatment group received lentivirus ... more

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Apoptosis; miR-1; Proliferation; Vestibular schwannoma

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 ... more

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Berberine; Glucagon; Hyperglycemia; Hypoxia-inducible factor-1; Tumor microenvironment

In this study, we examined the effect glucagon-induced hyperglycemia on tumor growth as well as the role of the hypoxia-inducible factor 1 (HIF-1)-vascular endothelial growth factor (VEGF) pathway in this condition. A high concentration of glucose (HG) was utilized to treat HeLa cells under hypoxic or normoxic conditions, and transcriptional levels of HIF-1, VEGF, and basic fibroblast ... more

Y. Wang; Y.D. Zhu; Q. Gui; X.D. Wang; Y.X. Zhu
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Antibiotics; Berberine; Dairy cow mastitis; Staphylococcus epidermidis

Berberine is a plant alkaloid with antimicrobial activity against a variety of microorganisms. In this study, the antimicrobial properties of berberine against multi-drug resistant field isolates of Staphylococcus epidermidis were investigated using berberine alone or in combination with a commonly used antibiotics in veterinary clinics, including penicillin, lincomycin, and ... more

X. Zhou; C. Yang; Y. Li; X. Liu; Y. Wang
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Bcl-2; Hypoxic ischemic brain injury; IL-18; Montelukast; Rat brain tissue; TERT

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J.L. Liu; X.H. Zhao; D.L. Zhang; J.B. Zhang; Z.H. Liu
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Bcl-2; Cervical cancer; KAI1; Metastasis; Survivin

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation with metastasis in cervical ... more

X.L. Zhou; M. Wang
06/21/2016
Apoptosis; Bcl-2; Borax; HepG2 cells; Mitochondrial membrane potential; p53

Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlying the growth inhibition induced by borax in HepG2 cells. The ... more

Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang; Y. Wei; F.J. Yuan; W.B. Zhou; L. Wu; L. Chen; J.J. Wang; Y.S. Zhang
09/01/2015
AIB1; Esophageal; Ki67; Squamous cell carcinoma

The aim of this study was to investigate the expression of AIB1 in human esophageal squamous cell carcinoma and its correlation with Ki67 expression. The immunohistochemical method streptavidin-perosidase was used to analyze the expression of AIB1 and Ki67 in specimens from 60 patients with esophageal squamous cell carcinoma and in 20 control individuals with normal esophageal tissue. ... more

L. Li; P. Wei; M.H. Zhang; W. Zhang; Y. Ma; X. Fang; C.L. Hao; Z.H. Zhang
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Cervical intraepithelial neoplasia; EZH2; Immunohistochemistry; p53 protein; Squamous cell carcinoma; Survival analysis

We investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) and p53 protein in cervical squamous cell carcinoma (SCC) and precancerous lesions. EZH2 and p53 expressions in SCC (168), cervical intraepithelial neoplasia (CIN)-I (19), CIN-II (35), and normal tissues (30) were detected by streptavidin-peroxidase-conjugation. The correlation between co- ... more

H.M. Zhang; S.Q. Chen; S.Z. Yao; H.M. Zhang; S.Q. Chen; S.Z. Yao
08/14/2015
Dental pulp cells; Mineralization; Platelet-rich plasma; Proliferation; Washed platelets

We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferation. Alizarin red staining was used ... more

L. Zhang; Y.H. Xie; B.R. Lin

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