Research Article

Related GMR Articles

Chronic obstructive pulmonary disease; Hypoxia-inducible factor-1α; Single nucleotide polymorphisms

In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction fragment length polymorphism was used to assess ... more

W.T. Wei; B. Li; M. Chen; H.R. Jia; H.X. Zhang
COL1A1; Gene polymorphism; Meta-analysis; Osteoporosis

Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. We conducted searches of the published literature in the ... more

K.H. Yu; J. Tang; C.Q. Dai; Y. Yu; J.J. Hong
Cervical carcinoma; Gene polymorphism; Meta-analysis; XRCC1

Numerous studies have evaluated the association between Arg399Gln polymorphism of DNA repair gene XRCC1 and cervical carcinoma risk. However, the specific association is still controversial. To assess the relationship between XRCC1 Arg399Gln polymorphism and cervical carcinoma, we conducted a comprehensive meta-analysis of 10 case-control studies with 2051 cervical carcinoma cases and ... more

D.Y. Liu; H.C. Liang; X.M. Xiao
AT1R; Gene polymorphism; Heart failure; Meta-analysis

The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using meta‑analysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the ... more

J.A. Zhang; J.R. Li; Y.J. Qiao
CYP4F2; Gene polymorphism; Hypertension; Meta-analysis

Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the CYP4F2 gene rs2108622 polymorphism and ... more

X.H. Luo; G.R. Li; H.Y. Li
Chronic obstructive pulmonary disease; Polymorphism; Vitamin D-binding protein

Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the Pubmed, Embase, and China ... more

M. Xiao; T. Wang; T. Zhu; F. Wen
Chronic obstructive pulmonary disease; Cost effectiveness; General practitioner; Quality of life; Quality-adjusted life years

We performed a 1-year cluster-randomized field trial to assess the effect of standardized management of chronic obstructive pulmonary disease (COPD) on lung function and quality of life (QOL) measures in patients in China. We used the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines and assessed indexes including pulmonary function, QOL, quality-adjusted ... more

Y.Q. Jiang; Y.X. Zhu; X.L. Chen; X. Xu; F. Li; H.J. Fu; C.Y. Shen; Y.Y. Lu; Q.J. Zhuang; G. Xu; Y.Y. Cai; Y. Zhang; S.S. Liu; M.Y. Zhu; S.H. Li
Chronic obstructive pulmonary disease; Gene polymorphism; Interleukin-6; Meta-analysis

Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Knowledge Infrastructure (CNKI) ... more

X.M. Xie; R. Ke; Y.H. Zhang; G.Z. Wang; Y.T. Zhu; T. Hussian; L. Yang; M.X. Li
14-prostaglandin J2; 15-Deoxy-delta12; Chronic obstructive pulmonary disease; NF-κB; Nrf2

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant and anti-inflammatory genes, and it plays a crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Moreover, 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) plays a protective role against oxidative stress and inflammation both in vivo and in ... more

X.Y. Li; B.L. Luo; L.J. Wang; W.D. Zhang; Z.G. Liu
Chronic obstructive pulmonary disease; Polymorphism; Proteinase-activated receptor-1

We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism assay was used to assess ... more

C.M. Yun; X.Y. Sang