Research Article

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12/07/2015
Atrial fibrillation; Gene polymorphism; KCNE1 (G38S); Uygur population

Current resources to support genetic screening among the Uygur population in Xinjiang territory for atrial fibrillation (AF) have not been well established and large-scale epidemiological analyses are needed. Using patients from the Xinjiang Uygur population as subjects, and the delayed rectifier potassium channel KCNE1 and its associated polymorphism G38S (rs1805127) as the candidate gene, we ... more

N. Wugeti; G. Yu-Jun; S. Juan; A. Mahemuti
12/02/2015
Atrial fibrillation; Connexin 40 (Cx40); Gene polymorphism; rs35594137

Atrial fibrillation (AF) occurrence has a known genetic component. Many reports have revealed a correlation between gene mutation and AF, involving genes related to ion channels, connexin (Cx), and those within the angiotensin system. In this study, the cor­relation between the Cx 40 polymorphism (rs35594137) and AF was investigated in patients with AF in the Xinjiang, Turpan, and Kashi ... more

Y. Feng; J. Sun; L. Wang; X.L. Hou
12/01/2015
Bladder cancer; Gene polymorphism; PCR-RFLP; Toll-like receptor

In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 2008 and February 2014. The TLR4-729G/C polymorphism was ... more

B. Wan; J. Tan; Q. Zeng; L.Y. He; Y. Gan; Y.B. Dai; K. Yao
11/19/2015
Diabetic nephropathy; Gene polymorphism; Hypoxia-inducible factor-1α

We examined the correlation between gene polymorphisms in hypoxia-inducible factor-1α (HIF-1α) Pro582Ser and type 2 diabetic nephropathy (DN). A total of 244 subjects with type 2 diabetes were recruited. The 1285-bp locus polymorphism of HIF-1α exon was detected using polymerase chain reaction-restriction fragment length polymorphism. C/T single nucleotide polymorphisms were detected at ... more

Y.X. Bi; L. Yu; G.X. Jin
10/29/2015
Calcium oxalate stones; Fibronectin; Gene polymorphism; Uighur

Here, we have investigated the correlation between calcium oxalate stone formation and Fn gene polymorphisms in urinary calculi patients among the Uighur population (Xinjiang region). In this case control study, genomic DNA extracted from the peripheral blood of 129 patients with calcium oxalate stones (patient group) and 94 normal people (control group) was used to genotype ... more

M. Murat; A. Aekeper; L.Y. Yuan; T. Alim; G.J. Du; A. Abdusamat; G.W. Wu; Y. Aniwer
10/26/2015
-174 G/C; Gene polymorphism; IL-6; Ischemic stroke

Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase databases were ... more

X.F. Jin; D.L. Wang; Y. Zhou; H. Xiong
02/19/2016
5-HT transporter gene-linked polymorphic region; Acute ischemic stroke; Gene polymorphism; Post-stroke depression

Post-stroke depression (PSD) is a mental illness characterized by subjective feelings of depression, cognitive dysfunction, and decreased interest. The serotoninergic system is involved in the pathogenesis of depressive disorders and is regulated by the serotonin transporter gene. The serotonin transporter-linked polymorphic region (5-HTTLPR) has been examined as a factor associated with ... more

W.Y. Guo; Z.H. Zhang; J.L. Mu; D. Liu; L. Zhao; Z.Y. Yao; J.G. Song; W.Y. Guo; Z.H. Zhang; J.L. Mu; D. Liu; L. Zhao; Z.Y. Yao; J.G. Song
10/17/2016
Atrial fibrillation; Connexin 40; Gene polymorphism

We aimed to elucidate the association between connexin 40 (Cx40) genetic polymorphisms and atrial fibrillation (AF) in a Chinese population in Xinjiang comprising Uyghur and Han individuals. We enrolled 275 Uyghur and 305 age- and gender-matched Han subjects, and used polymerase chain reaction to detect single nucleotide polymorphisms (SNPs; -44G/A and +71A/G) in ... more

J. Hailati; Y.C. Yang; L. Zhang; P.Y. He; M. Baikeyi; W. Muhuyati; Z.Q. Liu
10/24/2016
Gene polymorphism; Osteoarticular tuberculosis; Prognosis; Tumor necrosis factor-α

This study investigated the association of tumor necrosis factor-α (TNF-α)-308, -238, and -863 polymorphisms with osteoarticular tuberculosis (OA-TB) prognosis in a Hebei population. Genomic DNA was extracted from venous blood samples of 120 OA-TB patients and 100 healthy volunteers. TNF-α-308, -238, and -863 were analyzed by PCR-restriction ... more

Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang
11/03/2016
Correlation analysis; CYP1A1, GSTP1, ERCC2, XRCC1, XRCC3; Gene polymorphism; Lung cancer

Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual’s genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308 primary lung ... more

H.X. Liu; J. Li; B.G. Ye; H.X. Liu; J. Li; B.G. Ye

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