Research Article

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03/31/2014
NSCLC; SNPs; XPG; XRCC1; XRCC3

This study aimed to investigate the effects of single-nucleotide polymorphisms (SNPs) XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPG His104Asp, and XPG His46His in genes involved in the DNA-repair pathway on the outcomes of platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). ... more

Z.Y. Jin; X.T. Zhao; L.N. Zhang; Y. Wang; W.T. Yue; S.F. Xu
06/24/2016
EC-9706 cells; EGFR; ERCC1; Esophageal cancer; p53; SNX-2112

SNX-2112 is a potential molecular targeted therapeutic drug against esophageal cancer (EC). However, its exact mechanism of action remains to be explained. The aim of this study was to investigate the effect of SNX-2112 on excision repair cross- complementing 1 (ERCC1), epidermal growth factor receptor (EGFR), and p53, to elucidate the mechanism of action of SNX-2112 on EC. Fresh tumor ... more

C.Y. Li; Y.J. Ren; Y.D. Li; C.Y. Li; Y.J. Ren; Y.D. Li
03/30/2021
EGFR; Epidermal Growth Factor Receptor (ErbB-1; Her); Sinonasal cancer; SNSCC; Squamous cell carcinoma

Prognosis of sinonasal squamous cell carcinoma (SNSCC) depends on TNM (Tumor, Node, Metastasis) staging, histological manifestations, and activity of cell-surface receptors (p53, Ki67, EGFR − Epidermal Growth Factor Receptor (ErbB-1; Her1). EGFR is the best- studied transmembrane tyrosine kinase receptor. The intensity of tumor cells division and the rate of their ... more

N.D. Phuc; L.M. Ky; N.T. Binh; V.T.M. Thuc; N.T. Tuan; N.T.K. Van; T.X. Hai
11/25/2015
chromosome; FISH; Multigene families

In this study, fluorescence in situ hybridization (FISH) analysis was used to determine and compare the numbers and chromosomal locations of two multigene families (rDNA and histone H3) in four Neotropical species of gomphocerine grasshoppers. FISH using the 18S rDNA probe identified a single site on the S9 chromosome of Amblytropidia sp and Cauratettix borelli, ... more

L.C. Silva-Neto; A.C.S. Bernardino; V. Loreto; R.C. Moura
05/09/2016
Array CGH; Balanced reciprocal translocation; DiGeorge syndrome; FISH; Karyotype; Velocariofacial syndrome

Partial duplication of the long arm of chromosome 11 and the partial trisomy of 22q are uncommon karyotypic abnormalities. Here, we report the case of a 6-year-old girl who showed partial trisomy of 11q and 22q, as a result of a maternal balanced reciprocal translocation (11;22), and exhibited dysmorphic features, severe intellectual disability, brain malformations, and speech delay ... more

P.S. Zou; H.F. Li; L.S. Chen; M. Ma; X.H. Chen; D. Xue; D.H. Cao; P.S. Zou; H.F. Li; L.S. Chen; M. Ma; X.H. Chen; D. Xue; D.H. Cao
02/20/2018
Array-SNP; FISH; Prenatal diagnosis; Trisomy 7q11.23q21.3; VSD

The objective of prenatal diagnosis (PD) is to provide prenatal diagnostic testing services for genetic conditions that enable families to make informed choices consistent with their individual needs and values, and to support them in deal with the outcome of such testing. This case we reported is about two fetuses with ventricular septal defect (VSD) and trisomy ... more

K. Mu; L.Sha Chen; J. Wen; Y. Liu; N. Liu; D.Hua Cao
10/06/2022
Chromosomal microarray; Complex chromosomal rearrangement; FISH; Neurodevelopmental delay; PURA syndrome

Complex chromosomal rearrangements are extremely rare in humans. Most apparently balanced complex chromosomal rearrangements are de novo; they usually are detected in phenotypically normal subjects. Nevertheless, in some cases they are found in patients with multiple congenital abnormalities and neurodevelopmental disorders, which may be due to cryptic ... more

M.E. Minzhenkova; D.A. Yurchenko; N.A. Semenova; Z.G. Markova; A.A. Tarlycheva; N.V. Shilova
03/14/2023
DNA extraction; Fin clippings; FISH; PCR amplification; Proteinase K

Ideal DNA extraction techniques must be efficient in terms of time, labor, and costs, optimizing yield and quality of the DNA for the desired applications. We tested six DNA extraction methods: DNeasy® Blood & Tissue Kit, Cetyltrimethylammonium bromide (CTAB), Modified salting-out protocol (SA), Boiling Tissue, Proteinase K (PK) and Mini Kit Applied ... more

N.M.L. Silva; A.A. Campelo; A.R. Caetano; P. Ianella
09/21/2015
Breast cancer; GIT2; Metastasis; MTERF; Multiplex RT-PCR

Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive markers for metastatic risk. This multiplex ... more

S. Sirirattanakul; P. Wannakrairot; T. Tencomnao; R. Santiyanont
12/16/2015
Bcl-2; Cervical cancer; KAI1; Metastasis; Survivin

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation with metastasis in cervical ... more

X.L. Zhou; M. Wang

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