Research Article

Related GMR Articles

APOA-I; APOE; Coronary heart disease; HDL-C; High-density lipoprotein cholesterol; Polymorphism

Apolipoprotein E (APOE) is recognized for its importance in lipoprotein metabolism and cardiovascular disease. We evaluated the association between APOE rs4420638 genotypes and circulating lipid concentrations along with the risk of coronary heart disease (CHD). We conducted a case-control study involving 1508 individuals to investigate the contribution of rs4420638 to ... more

Y. Huang; H.D. Ye; X. Gao; S. Nie; Q.X. Hong; H.H. Ji; J. Sun; S.J. Zhou; B. Fei; K.Q. Li; J.K. Zhao; Z.P. Wang; M.Q. Xu; S.W. Duan
APC; Coronary heart disease; male; rs383830

APC is a tumor suppressor gene that is involved in the processes of cell migration and adhesion, transcriptional activation, and apoptosis. The goal of this study was to evaluate the contribution of the APC rs383830 polymorphism to coronary heart disease (CHD) in Han Chinese. A total of 783 patients with CHD and 737 controls were tested in the current association study. Although ... more

J.Y. Zhong; X.W. Zheng; H.D. Ye; H.B. Cui; W.P. Du; Z.X. Zhang; X.H. Fei; S.Y. Lin; J. Wang; J. Su; X.M. Chen; S.W. Duan
Coronary heart disease; Gene polymorphism; Methylene tetrahydrofolate reductase; Serum homocysteine levels

The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD). We consecutively enrolled 208 patients with CHD confirmed by CTA or coronary angiography from our hospital. An additional 200 healthy volunteers were enrolled as the control ... more

Y.Y. Chen; B.N. Wang; X.P. Yu; Y.Y. Chen; B.N. Wang; X.P. Yu; Y.Y. Chen; B.N. Wang; X.P. Yu
Coronary heart disease; N-acetyltransferase-2; Polymerase chain reaction; Polymorphism; Rapid acetylator genotype; Slow acetylator genotype

We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People’s Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N = 41) subgroups. DNA samples ... more

J.D. Sun; H. Yuan; H.Q. Hu; H.M. Yu; J.D. Sun; H. Yuan; H.Q. Hu; H.M. Yu
Adiponectin; Adrenergic receptor; Cardiometabolic risk factor; Obesity; Polymorphism

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers ... more

V.A. Genelhu; E.A. Francischetti; S.F.P. Duarte; B.M.J. Celoria; R.C. Oliveira; P.H. Cabello; M.M.G. Pimentel
Adiponectin; Adult GHD; Leptin; Visfatin

We aimed to determine the significance and changes in leptin, adiponectin (ADP), and visfatin levels in adults with growth hormone deficiency (GHD). Forty adults (19 men, 21 women) who had been diagnosed with GHD comprised the observation group, while 36 healthy adults (18 men, 18 women) were used as the control group. Fasting venous blood was collected to detect leptin, ADP, and ... more

Z.P. Li; M. Zhang; J. Gao; G.Y. Zhou; S.Q. Li; Z.M. An
Adiponectin; Insulin resistance; Nonalcoholic fatty liver disease; Tumor necrosis factor-a; Type 2 diabetes mellitus

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease caused by non-excessive alcohol consumption and is the most common cause of elevated levels of serum liver enzymes. We examined changes in adiponectin (APN) and tumor necrosis factor-α (TNF-α) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resistance (IR). Forty-two T2DM, 39 ... more

X. Lin; Z. Zhang; J.M. Chen; Y.Y. Xu; H.R. Ye; J. Cui; Y. Fang; Y. Jin; D.R. Zhu; L. Yuan
Osteoprotegerin; Ovariectomized rats; Receptor activator of nuclear factor-kB ligand

We established animal models of osteoporosis in ovari­ectomized rats to detect osteoprogerin (Opg)/receptor activator of nuclear factor-κB ligand (Rankl) mRNA expression levels in the tib­ias and serum estradiol concentrations at different time points. Sixty Sprague-Dawley female rats were randomly selected and divided into an ovariectomized (OVX) group and sham-operated ... more

C.W. Li; B. Liang; X.L. Shi; H. Wang
Apolipoprotein A-V; Apolipoprotein C-III; Coronary heart disease; Polymorphism; Single nucleotide polymorphisms; Triglycerides

The aim of this study was to investigate correlations between apolipoprotein A-V (APOA5) -1131T>C and apolipoprotein C-III (APOC3) -455T>C polymorphisms and coronary heart disease (CHD). PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched using combinations of keywords relating to these polymorphisms ... more

Y. Sun; R.B. Zhou; D.M. Chen
Coronary heart disease; Han Chinese population; Matrix metalloproteinase; Polymorphism

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case ... more

C.M. Wang; H.D. Ye; Y.R. Li; Q.X. Hong; L.L. Tang; A.N. Zhou; M.Q. Xu; S.W. Duan