Research Article

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In this study, we observed changes in CD4+ CD25+ Foxp3+ Treg expression in rats with osteoarthritis (OA) to explore the role that CD4+ CD25+ Foxp3+ Treg plays in the decline in the condition of OA rats. Thirty rats were randomly divided into 2 groups equally ... more

S.Y. Guo; Y.J. Ding; L. Li; T. Zhang; Z.Z. Zhang; E.S. Zhang
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Gelatinase; Matrix metalloproteinases; MMP-1; MMP-2; MMP-9; Osteoarthritis

Our study examined the relationship between the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-9 proteins and the pathogenesis of osteoarthritis (OA). We employed rigorous inclusion and exclusion criteria in computer-based bibliographic databases to extract published studies relevant to this investigation. The STATA 12.0 software was used for the statistical analyses. A ... more

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Cartilage oligomeric matrix protein; Matrix metalloproteinase-3; Osteoarthritis; Reversible

The main pathological characteristic of osteoarthritis (OA) is cartilage damage. We explored cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3) changes during articular cartilage injury and repair. Rabbits were randomly divided into the following: a blank control group; groups M1, M2, and M3, in which breaking was performed for 2, 4, and 6 weeks, ... more

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Articular cartilage bone; Correlation analysis; Interleukin-6; Osteoarthritis

This study aimed to investigate the expressional profile of interleukin-6 (IL-6) in articular cartilage bone of osteoarthritis (OA) patients and its correlation with OA. A total of 30 articular cartilage bone samples from knee OA patients, which were collected by knee arthroscopy or articular surgery, comprised the study group, and 30 samples of normal articular cartilage tissue comprised ... more

X.Q. Qu; W.J. Wang; S.S. Tang; Y. Liu; J.L. Wang
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Exercise; Interleukin-15; Osteoarthritis; Synovial fluid; Synovium

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In this study, we investigated the differential expression profiles of cyclooxygenase-2 (COX-2) mRNA and proteins in osteoarthritis (OA) and rheumatoid arthritis (RA) patients to elucidate the role of COX-2 expression in the pathogenesis and development of these diseases and to provide novel drug targets for treating arthritis. A total of 60 patients who received arthroscopic surgeries ... more

H.W. Fan; G.Y. Liu; C.F. Zhao; X.F. Li; X.Y. Yang
07/15/2016
Bone matrix; Cartilage; Chitosan; Chondrocyte; Composite scaffold; Tissue engineering

This study was designed to evaluate bone matrix gelatin (BMG)/fibrin glue and chitosan/gelatin composite scaffolds for cartilage tissue engineering. Chondrocytes were isolated from costal cartilage of Sprague-Dawley rats and seeded on BMG/fibrin glue or chitosan/gelatin composite scaffolds. After different in vitro culture durations, the scaffolds were subjected to hematoxylin ... more

Z.H. Wang; J. Zhang; Q. Zhang; Y. Gao; J. Yan; X.Y. Zhao; Y.Y. Yang; D.M. Kong; J. Zhao; Y.X. Shi; X.L. Li; Z.H. Wang; J. Zhang; Q. Zhang; Y. Gao; J. Yan; X.Y. Zhao; Y.Y. Yang; D.M. Kong; J. Zhao; Y.X. Shi; X.L. Li
08/17/2017
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A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1 ... more

Z.X. Qiu; Z.S. Sha; X.M. Che; M.Y. Wang
08/17/2017
ADAMTS4 Protein; Adult; Biomarkers; Cartilage; Case-control studies; Female; Humans; male; MAP Kinase Kinase Kinases; Middle Aged; Tuberculosis, Spinal; Vascular cell adhesion molecule-1

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1 ... more

Z.X. Qiu; Z.S. Sha; X.M. Che; M.Y. Wang
05/09/2016
Advanced glycation end-products; Chondrocytes; Matrix metalloproteinase-9; NF-κB; Reactive oxygen species; TGF-β

Peroxisome proliferator-activated receptor is closely associated with the pathogenesis of osteoarthritis. The level of exogenous advanced glycation end-products (AGEs) in articular cartilage is highly associated with the severity of osteoarthritic lesions. However, their interactions and role in promoting osteoarthritisprogression remain unclear. Here, we investigated the effect of AGEs ... more

J. Wang; G. Wang; G.W. Sun; J. Wang; G. Wang; G.W. Sun