Research Article

Related GMR Articles

CDKAL1; Meta-analysis; Single nucleotide polymorphism; Type 2 diabetes

CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for rs10946398 variants of the CDKAL1 gene to ... more

M.A.S. Dehwah; M. Wang; Q.Y. Huang
Association study; Meta-analysis; Type 2 diabetes; UCP2

Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotype, P = 0.508) or for the ... more

L.J. Qin; J. Wen; Y.L. Qu; Q.Y. Huang
ABCC8; KCNJ11; Meta-analysis; miRNA; Type 2 diabetes

KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11) and ABCC8 (ATP-binding cassette, subfamily C (CFTR/MRP), member 8) have been studied for association with type 2 diabetes in various ethnic populations with contradictory results. We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to ... more

L.J. Qin; Y. Lv; Q.Y. Huang
Blood glucose; Elderly; Gastric emptying; Rehabilitation management; Type 2 diabetes

The relationship between gastric emptying dysfunction and blood glucose concentration in elderly with type 2 diabetes mellitus was investigated, and the effect of rehabilitation exercise prescription training on gastric emptying in the geriatric diabetic patients was evaluated. A total of 160 older type 2 diabetic adults and 30 cases of non-diabetic patients were studied with regard to ... more

Z.M. Shao; J.F. Yao; J. Chen; Z.W. Yu; X.F. Yu; J.J. Zheng; X. Tang
Genetic polymorphisms; Mixed population; rs12255372; rs7903146; TCF7L2; Type 2 diabetes

Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in ... more

C.M.A.R. Barros; A.P. Araújo-Neto; T.R. Lopes; M.A.L. Barros; F.J.N. Motta; R. Canalle; L.C.C. Nunes; J.A. Rey; R.R. Burbano; M.A. Lima-Barros; F.K.N. Yoshioka; G.R. Pinto
Energy metabolism; Insulin-sensitive tissues; Oligonucleotide microarray; Type 2 diabetes

Impaired insulin action within skeletal muscle, adipose tissue, and the liver is an important characteristic of type 2 diabetes (T2D). In order to identify common underlying defects in insulin-sensitive tissues that may be involved in the pathogenesis of T2D, the gene expression profiles of skeletal muscle, visceral adipose tissue, and liver from autopsy donors with or without T2D were ... more

M. Wang; X.C. Wang; L. Zhao; Y. Zhang; L.L. Yao; Y. Lin; Y.D. Peng; R.M. Hu
Color Doppler ultrasound; Lower extremity vasculopathy; Risk factors; Type 2 diabetes

This study aims to investigate the value of high-resolution color Doppler ultrasonography (HR-CDU) in the evaluation of lower-extremity vasculopathy (LEV) and its related risk factors in type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent lower-extremity arterial HR-CDU. The patients were divided into the LEV group (V group) and the ... more

J. Xu; G. Wang; D. Fu; N. Su; L. Wang; F. Gao; N. Guo
CAPN10 polymorphisms; Mexican mestizo; Type 2 diabetes

The calpain-10 gene is expressed primarily in tissues important in glucose metabolism; thus, some of its polymorphisms have been associated with type 2 diabetes. In this study, we examined the association between the calpain-10 single-nucleotide polymorphism (SNP)-43, SNP-19, and SNP-63 and type 2 diabetes in Mexican mestizos. We included 211 patients and 152 non-diabetic subjects. ... more

V.J. Picos-Cárdenas; E. Sáinz-González; A. Miliar-García; A. Romero-Zazueta; R. Quintero-Osuna; E. Leal-Ugarte; V. Peralta-Leal; J.P. Meza-Espinoza
Chinese; Metabolic syndrome; Obesity; Polymorphism; Type 2 diabetes

Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjects. A total of 240 T2D subjects ... more

Y.L. Chen; D. Pei; Y.J. Hung; C.H. Lee; F.C. Hsiao; C.Z. Wu; J.D. Lin; C.H. Hsu; J.B. Chang; C.H. Hsieh
IgG4 Fc; Insulin sensitizer; Type 2 diabetes; Yiminsu

Insulin resistance is a key feature of obesity and type 2 diabetes mellitus (T2DM). Interaction of insulin with the insulin receptor (IR) leads to both its auto-phosphorylation and phosphorylation of tyrosine residues on the IR substrate (IRS) proteins, initiating the activation of intracellular signaling cascades. The metabolic effects of IRS are known to be mediated through pathways ... more

J. Wang; T. Zou; H.X. Yang; Y.Z. Gong; X.J. Xie; H.Y. Liu; D.F. Liao