Research Article

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11/14/2014
Chinese Han population; Chinese Hui population; Polymorphism; Type 2 diabetes mellitus; Vitamin D receptor

We investigated the association between vitamin D receptor (VDR) and susceptibility to type 2 diabetes mellitus (T2DM). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was conducted to examine single nucleotide polymorphisms (SNPs) of the rs1544410 (BsmI, G>A), rs757343 (Tru9I, G>A), rs731236 (TaqI, T>C), and ... more

J.R. Xu; Y. Yang; X.M. Liu; Y.J. Wang
09/26/2014
Bone mineral density; BsmI; Gene polymorphism; Meta-analysis; Vitamin D receptor

The vitamin D receptor BsmI gene polymorphism is reportedly associated with low bone mineral density (BMD) in postmenopausal women, but results from previous studies are conflicting. In the present study, we investigated the association between this polymorphism and the risk of low BMD through a meta-analysis of published studies. A literature search of the Pubmed, Embase, and ... more

C. Ma; Q.L. Zhou; Y.J. Deng; X. Liang; D.P. Wu; Y.Z. Dong
07/24/2014
Gallbladder cancer; susceptibility; Vitamin D receptor

The aim of this study was to test for the possible association between vitamin D receptor (VDR) genetic variants and susceptibility to gallbladder cancer (GBC). A total of 291 GBC cases were recruited and 396 gender- and age-matched healthy volunteers were enrolled as controls. The VDR gene polymorphisms were determined in all subjects. The genotype and the allele frequencies of ... more

Z. Li; W.T. Yuan; S.J. Ning; S.J. Zhang
04/08/2014
Association study; Inflammatory bowel diseases; Meta-analysis; Polymorphism; Vitamin D receptor

The gene encoding vitamin D receptor (VDR) is recognized as a promising candidate for indicating the development of inflammatory bowel disease (IBD). Four genetic polymorphisms (ApaI, BsmI, FokI, TaqI) in VDR have been widely evaluated to determine their association with IBD, and the results of these evaluations are often inconsistent. ... more

L. Wang; Z.T. Wang; J.J. Hu; R. Fan; J. Zhou; J. Zhong
06/11/2015
FokI polymorphism; Tuberculosis; Vitamin D receptor

Numerous studies have evaluated the association between FokI polymorphisms in the vitamin D receptor (VDR) gene and tuberculosis risk. However, the specific association remains controversial. In this study, we performed a meta-analysis to assess the association between the VDR gene FokI polymorphism and tuberculosis. Published studies from the PubMed and Embase ... more

Y.P. Sun; Q.S. Cai
08/07/2015
Meta-analysis; Polymorphism; Pulmonary tuberculosis; Vitamin D receptor

The aim of this study was to determine whether vitamin D receptor (VDR) genetic polymorphisms are associated with the susceptibility to pulmonary tuberculosis (PTB). MEDLINE and Embase databases and manual literature searches were used. A meta-analysis was conducted on the associations between the VDR FokI, TaqI, BsmI, and ApaI polymorphisms ... more

Y.H. Lee; G.G. Song
10/09/2015
Chronic periodontitis; Single nucleotide polymorphism; Vitamin D receptor

The vitamin D receptor (VDR) is involved in the immune response and bone metabolism, both of which are implicated in the pathogenesis of chronic periodontitis (CP). In this study, we investigated the association between the VDR single nucleotide polymorphism rs2228570 and CP susceptibility in a Han Chinese population consisting of 440 moderate or severe CP patients and 324 controls. ... more

X. Wang; T.L. Zhang; D. Chen
10/06/2016
Meta-analysis; Periodontitis; Polymorphism; Vitamin D receptor

Although a number of studies have been conducted to determine the association between vitamin D receptor (VDR) TaqI polymorphism and periodontitis in the Chinese population, this association remains elusive. To assess the influence of VDR TaqI polymorphism on the risk of periodontitis, a meta-analysis was performed in a Chinese population. Relevant studies were ... more

X.W. Ji; Y. Wang; C. Cao; L.J. Zhong; X.W. Ji; Y. Wang; C. Cao; L.J. Zhong
08/14/2015
Alopecia areata; Case-control study; CXCL1; CXCL2; Polymorphism

Alopecia areata (AA) is a common disease, which causes hair loss in humans. AA has a genetically complex inheritance. This study investigated the possible correlations between single nucleotide polymorphisms (SNPs) in the promoter regions of the chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2 ... more

S.K. Kim; J.H. Chung; H.J. Park; S.W. Kang; D.J. Lim; S.H. Byun; D.G. Baek; H.Y. Ko; B.L. Lew; H.H. Baik; W.Y. Sim
12/14/2015
Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

W. Pan; H. Liao

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