Research Article

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03/09/2010
Abnormal Hb; Anemia; Hemoglobinopathies; Polymorphism; thalassemia

We looked for abnormal hemoglobins in blood samples sent for diagnosis of anemia. Identification of the hemoglobins was made using electrophoretic, chromatographic and molecular procedures. The 2020 blood samples were of patients from various regions of Brazil and from some other Latin American countries. Among the abnormal hemoglobins that we found, 3.5% are known to be rare, while 51% ... more

P.J.A. Zamaro; C.R. Bonini-Domingos
04/13/2010
Colorectal cancer; Kashmir; Polymorphism; Restriction digestion; RFLP; TP53

Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to determine if these two SNPs are ... more

A.S. Sameer; Z.A. Shah; N. Syeed; M.Z. Banday; S.M. Bashir; B.A. Bhat; M.A. Siddiqi
01/19/2010
Elderly; HDL cholesterol; Lipoprotein lipase; Polymorphism; Triglycerides

Lipoprotein lipase is essential for triglyceride hydrolysis. The polymorphisms S447X in exon 9 and HindIII in intron 8 have been associated with lower triglyceride levels and lower cardiovascular risk in adult men. We examined the association of these lipoprotein lipase polymorphisms with high-density lipoprotein (HDL) and triglyceride levels in elderly men. Blood samples were ... more

L.M.Q. Araújo; M.S. Cendoroglo; C.O. Gigek; E.S. Chen; deA.C. Smith
12/19/2013
Cerebrovascular disease; Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Stroke

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected ... more

Q.Q. Lv; J. Lu; W. Wu; H. Sun; J.S. Zhang
12/13/2013
Mastitis; PCR-PIRA; PCR-RFLP; Percentage of fat; PGLYRP-2 gene; Polymorphism

Peptidoglycan recognition protein 2 (PGLYRP-2), which belongs to the PGRP family, is the only member that has no direct bactericidal activity but has N-acetylmuramoyl-l-alanine amidase activity. This feature of PGLYRP-2 indicates that it may play an important role in eliminating the pathogen associated molecular pattern (PAMP), such as peptidoglycan (PGN), which can reduce ... more

H.L. Wang; Z.X. Li; L. Chen; J. Yang; L.J. Wang; H. He; F.B. Niu; Y. Liu; J.Z. Guo; X.L. Liu
12/13/2013
Beef cattle; Carcass and meat quality traits; Myf6; MyoD1; PCR-RFLP; Polymorphism

Myogenic determination factor 1 (MyoD1) and myogenic factor 6 (Myf6) genes belong to the myogenic differentiation (MyoD) gene family, which play key roles in growth and muscle development. The study aimed to investigate the effects of variants in cattle MyoD1 and Myf6 on carcass and meat traits. We screened single nucleotide polymorphisms (SNPs ... more

X.H. Du; Q.F. Gan; Z.R. Yuan; X. Gao; L.P. Zhang; H.J. Gao; J.Y. Li; S.Z. Xu
04/26/2013
CCND1 gene; Esophageal cancer; Genetic association; Meta-analysis; Polymorphism

The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic ... more

W. Cai; Z.T. Wang; J. Zhong; Y. Zhang
12/11/2013
Growth traits; Insulin-like growth factor II; Polymorphism; Yak

Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth and is involved in stimulating fetal cell division, differentiation, and metabolic regulation. IGF-II is considered a candidate gene for genetic markers of growth and carcass traits. Therefore, in this study, the associations of single nucleotide polymorphisms (SNPs) in the IGF-II gene region with growth and ... more

Y.F. Zeng; X.Z. Ding; S.R. Cheng; S.J. Yu
01/04/2013
Hepatocellular carcinoma; MIF-794CATT; Polymorphism; Promoter

Hepatocellular carcinoma (HCC) is one of the most common worldwide malignancies. A relative complete diagnosis system for primary carcinoma of liver has already been established, but the surgical prognosis for HCC, which depends mainly on postoperative pathological classification and data of recurrence and metastasis, lacks valid experimental indicators. Macrophage migration inhibition ... more

T. Yuan; C. Tang; M. Chen; S. Deng; P. Chen
12/13/2013
CCND1; Esophageal squamous cell carcinoma; Polymorphism; PTEN

Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred and four ESCC patients and 413 ... more

Y. Jang; S.A. Lu; Z.P. Chen; J. Ma; C.Q. Xu; C.Z. Zhang; J.J. Wang

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