Research Article

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07/08/2013
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Association signal; Colorectal cancer; IL6 gene; Meta-analysis; Polymorphism

Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studies on the role of ... more

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Polymorphism; Saudi; Tumor necrosis factor; Vitiligo

Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic proinflammatory cytokine, has been shown to play a critical role in several autoimmune diseases ... more

F. Al-Harthi; A. Zouman; M. Arfin; M. Tariq; A. Al-Asmari
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Growth differentiation factor 9; Holstein bulls; Polymorphism; Sperm quality

Members of the transforming growth factor-β (TGFβ) superfamily are critical regulators of germ cell development that act as extracellular ligands of the signal transduction pathways regulating proliferation, differentiation, apoptosis, and other aspects of cell behavior. Growth differentiation factor 9 (GDF9) is a member of the TGFβ superfamily that plays a critical role in ovarian ... more

K.Q. Tang; W.C. Yang; X.X. Zhang; L.G. Yang
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Leptin; Leptin receptor; Polymorphism; Preeclampsia

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and ... more

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5-Lipoxygenase activating protein; Cerebral infarction; Cyclooxygenase; Genetics; Polymorphism

We made a case-control study to investigate a possible association between ALOX5AP-SG13S114A/T, COX-2-765G/C, and COX-1-50C/T polymorphisms with cerebral infarction in a Chinese population. A total of 411 cases with cerebral infarction were included; 411 controls matched for age, gender, and risk factors were also selected. The ... more

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05/14/2013
Association risk; Coronary artery stenosis; KLK1 A1789G gene; Polymorphism

Previous reports have shown that polymorphism of the human tissue kallikrein 1 (KLK1) A1789G gene is associated with susceptibility to hypertension. The current study aimed to confirm the association between the polymorphism in KLK1 and coronary artery stenosis (CAS). A total of 458 patients with CAS and 482 controls were used in a case-control study carried out between ... more

Q.D. Li; F.J. Li; X.C. Liu; H. Jiang
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GNAQ; Han Chinese population; Polymorphism; Rheumatoid arthritis

Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activ­ity. These indicate that Gαq plays critical roles in the ... more

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Chinese Holstein cow; Milk performance traits; Polymorphism; STAT4

The signal transducer and activator of transcription (STAT) genes are responsive to a wide range of cytokines, growth factors, and hormones, and thus control important biological processes. In humans, STAT4 mutations have been identified as genetic markers for rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome, whereas little research has ... more

X.M. Song; L. Zhang; J.F. Jiang; F.X. Shi; Y.Q. Jiang
04/25/2013
ACE gene; Chronic obstructive pulmonary disease; Polymorphism

An insertion/deletion (I/D) polymorphism was identified in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoking control individuals ... more

S. Simsek; S. Tekes; D. Oral; A. Turkyılmaz; B. Isik; M.R. Isik; H. Akkoc

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