Research Article

Related GMR Articles

08/28/2014
Diabetes mellitus; Genetic polymorphisms; HNF1β; Meta-analysis; Prostate cancer

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the ... more

Y.Z. Xiang; S.B. Jiang; J. Zhao; H. Xiong; Z.L. Cui; G.B. Li; X.B. Jin
07/07/2014
Asian; Hepatocellular carcinoma; Meta-analysis; Methylation; RUNX3

Runt-related transcription factor 3 (RUNX3) is a potential tumor suppressor that is frequently hypermethylated in hepatocellular carcinoma (HCC). The present meta-analysis of case-control studies was carried out to determine whether RUNX3 hypermethylation is associated with HCC. The PubMed, Embase, and Chinese National Knowledge Infrastructure databases were searched for ... more

X.X. Lu; L.Q. Zhu; F. Pang; W. Sun; C. Ou; Y. Li; J. Cao; Y.L. Hu
07/24/2014
Deep vein thrombosis; Meta-analysis; Randomized controlled trial; Thrombolysis

We performed a meta-analysis for systematic evaluation of the status quo of catheter thrombolysis for the treatment of acute lower limb deep vein thrombosis in China. We searched the China Biomedical bibliographic database (CBM), China National Knowledge Infrastructure (CNKI), Weipu full-text electronic journals, Wanfang full-text database, and Medline (1990 through June 2011) ... more

J.J. Zheng; Z.H. Zhang; Z. Shan; W.J. Wang; X.X. Li; S.M. Wang; Y.X. Li; G.S. Cheng
03/06/2014
Coronary artery disease; Meta-analysis; PTGS2

Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conducted a search of case-control studies on the ... more

C.L. Xuan; W. Yan; L. Xuan; R.H. Xu
02/28/2014
Asthma; IL-4; Meta-analysis; Polymorphisms; Promoter

This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly ... more

L. Tang; H.G. Lin; B.F. Chen
01/08/2014
Gene polymorphism; Head and neck carcinomas; Meta-analysis; p53 codon 72

Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) to derive a more precise estimation of this association ... more

W.H. Ren; D.K. Jiang; Y. Pei; S.Q. Wang; X.M. Yang; L. Yu
06/12/2015
Esophageal cancer; Meta-analysis; miR-21; Prognosis

The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of case, etc. from the studies ... more

S.W. Wen; Y.F. Zhang; Y. Li; Z.X. Liu; H.L. Lv; Z.H. Li; Y.Z. Xu; Y.G. Zhu; Z.Q. Tian
05/25/2015
Meta-analysis; Monocyte chemoattractant protein-1; Tuberculosis

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The ... more

G. Tian; X. Li; H. Li; X. Wang; B. Cheng
05/18/2015
Ankylosing spondylitis; Gene expression; Meta-analysis; Pathway analysis

The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in ankylosing spondylitis (AS). We performed a meta-analysis using the integrative meta-analysis of expression data program on publicly available microarray AS Gene Expression Omnibus (GEO) datasets. We performed Gene Ontology (GO) enrichment ... more

Y.H. Lee; G.G. Song
04/22/2015
Angiotensinogen; Gene polymorphism; Meta-analysis; Myocardial infarction

Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensive search was conducted to ... more

P.Y. Hu; Y.W. Wang; X.H. Pang; H.W. Wang

Pages