Research Article

Related GMR Articles

06/11/2015
GST; GSTM1; Polymorphism; Pterygium

The first reports about pterygium date back to Hip­pocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascular­ized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium ... more

deP.R. Júnior; G.Mdos Reis; K.S.Fe Silva; D.A. Rodrigues; M.C.S. Gomes; J.V.M. Martins; I.R. da Costa; G.A. Freitas; K.K.V.O. Moura
05/25/2015
AGT; Essential hypertension; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature search of the Google Scholar, PubMed, and ... more

R. Yao; Y.Y. Du; Y.Z. Zhang; Q.H. Chen; L.S. Zhao; L. Li
05/25/2015
Meta-analysis; Polymorphism; Rheumatoid arthritis; Tumor necrosis factor; Vitiligo

We investigated whether the tumor necrosis factor-a (TNF-α) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-α polymorphisms were determined in RA or vitiligo patients and controls. Meta-analysis was used to ... more

Y.H. Lee; S.C. Bae
05/18/2015
Chronic obstructive pulmonary disease; Meta-analysis; Polymorphism; Tumor necrosis factor-alpha

The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify ... more

K. Cui; X.Y. Ge; H.L. Ma
05/11/2015
Glaucoma; Meta-analysis; Polymorphism; TNF-α

The purpose of this study was to examine whether tu­mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex­amining the association between TNF-α -308 A/G and -238 A/G poly­morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The ... more

Y.H. Lee; G.G. Song
05/11/2015
Hepatitis B; Meta-analysis; MicroRNA; Polymorphism

Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk. A digital search was performed ... more

G.Q. Zhou; H. Meng; J.R. Wang; F.X. Sun; X.J. Wang; R.B. Wang; X.B. Wang
05/04/2015
Association study; Lung cancer; Polymorphism; TERT-CLPTM1L

Genome-wide association studies in several ethnic groups have reported that polymorphisms of the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes, located on 5p15.33, are associated with susceptibility to lung cancer. However, whether genetic variants of TERT-CLPTM1L are associated with an increased risk of ... more

S.G. Liu; L. Ma; Q.H. Cen; J.S. Huang; J.X. Zhang; J.J. Zhang
04/27/2015
Breast carcinoma; Meta-analysis; Microsomal epoxide hydrolase; Polymorphism

Carcinogenesis of breast carcinoma is very complicated. Previous studies have suggested conflicting results regarding the association between Tyr113His and His139Arg microsomal epoxide hydrolase (mEH) gene polymorphisms and risk of breast carcinoma. We conducted a meta-analysis to examine the relationship between these polymorphisms and breast carcinoma risk. We searched the ... more

J.H. Zhong; L.Q. Li; X.S. Mo; W.F. Gong; L. Ma; J. Chen; X.M. You
04/22/2015
Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Psoriasis

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T ... more

J.H. Qi; N. Shi; Y.J. Chen; G. Nie
04/17/2015
Angiotensin-converting enzyme; Meta-analysis; Polymorphism; Sarcoidosis

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence ... more

R. Zhu; L.Q. Bi; H. Kong; S.L. Tilley; H. Wang; W.P. Xie

Pages