Brief Note

Related GMR Articles

03/27/2015
Saliva; Salivary gland; Type 2 diabetes mellitus; α2-MG

We investigated the expression of salivary α2-macroglobulin (α2-MG) in patients with type 2 diabetes mellitus (T2DM) to investigate its value for predicting damage to the salivary glands. A total of 116 patients with T2DM and 60 patients with impaired fasting glucose (IFG) were included in this study. Sixty health volunteers were enrolled as a control group. Unstimulated saliva was ... more

J.K. Feng; Y.F. Lu; J. Li; Y.H. Qi; M.L. Yi; D.Y. Ma
08/21/2015
Chinese Hui population; Polymorphism; TCF7L2; Type 2 diabetes mellitus

Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated ... more

Y. Yang; J.R. Xu; Y.J. Wang; X.M. Liu
12/14/2015
Gastric bypass surgery; Gluconeogenesis; Phosphoenolpyruvate carboxykinase; Type 2 diabetes mellitus

The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (control) groups (N = 12 per group ... more

J. Wu; S.S. Hou; W. Wang; M. Yin; N. Cheng; L.L. Ge; J.J. Yin; J. Xu
12/01/2015
Association study; Candidate genes; Insulin resistance; Quantitative traits; Type 2 diabetes mellitus

Recent genome-wide association studies have identified many loci associated with type 2 diabetes mellitus (T2DM), hyperuricemia, and obesity in various ethnic populations. However, quantitative traits have been less well investigated in Han Chinese T2DM populations. We investigated the association between candidate gene single nucleotide polymorphisms (SNPs) and metabolic syndrome-related ... more

F.J. Wei; C.Y. Cai; P. Yu; J. Lv; C. Ling; W.T. Shi; H.X. Jiao; B.C. Chang; F.H. Yang; Y. Tian; M.S. Li; Y.H. Wang; L. Zou; J.M. Shi; L.M. Chen; W.D. Li
04/07/2016
Cardiovascular disease; Glutathione S-transferase; Malaysia; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the effect of GST polymorphisms on the ... more

A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail
01/31/2022
Brazilian population; Genetic epidemiology; Genetic susceptibility; Polymorphisms; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a chronic, complex, multifactorial and polygenic disease, constituting one of the greatest public health challenges worldwide. The genetic background has been shown to strongly influence the disease’s susceptibility. We performed genetic screening of risk-variants for T2DM and complications in the Brazilian population. This ... more

J.S. Campos; K.F. Santos; C.C.P. Costa; J.B.S. Barros; V.S.S. Gonçalves; L.P. Assunção; A.A.S. Reis; R.S. Santos
03/14/2023
Gliclazide; Metformin; SLC2A2 gene; Type 2 diabetes mellitus; Vietnam

In recent years, the number of people with type 2 diabetes mellitus has increased rapidly and it has become an important public health problem in Vietnam. To provide valuable information on the efficacy and safety of diabetes medications (metformin and gliclazide), we evaluated how they affected the expression level and mutations of the SLC2A2 gene in the liver of ... more

D.M. Nguyen; M.T. Nguyen; T.T.Bich Vo; M.N. Nghiem; S.T. Dao