Research Article

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06/29/2015
Alzheimer’s disease; Apolipoprotein E; Meta-analysis; Polymorphism; PPARγ

We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferator-activated receptor gamma (PPARγ) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between the PPARγ Pro12Ala and His447His polymorphisms and AD in subjects. The meta-analysis was performed according to the ... more

Y.H. Lee; G.G. Song
06/11/2015
Coronary heart disease; Meta-analysis; Polymorphism; PPARD; rs2016520

PPARD encodes peroxisome proliferator-activated re­ceptor delta, which has been shown to play an important role in control­ling lipid metabolism and atherosclerosis. In this case-control study, we explored the relationship between PPARD rs2016520 polymorphism and coronary heart disease (CHD) in a Han Chinese population. A to­tal of 657 CHD cases and 640 controls were included in the ... more

H.D. Ye; Y.R. Li; Q.X. Hong; A.N. Zhou; Q.L. Zhao; L.M. Xu; M.Q. Xu; X.T. Xu; L.L. Tang; D.J. Dai; D.J. Jiang; Y. Huang; D.W. Wang; S.W. Duan
06/12/2015
Esophageal cancer; Meta-analysis; miR-21; Prognosis

The present study aimed to explore the relationship between miRNA expression and survival in patients with esophageal cancer (EC) using meta-analysis. We searched PubMed, EMBASE, CNKI, Wanfang, and ISI Web of Science databases without time restrictions, and extracted relevant data, such as the name of first author, publication year, age, gender, number of case, etc. from the studies ... more

S.W. Wen; Y.F. Zhang; Y. Li; Z.X. Liu; H.L. Lv; Z.H. Li; Y.Z. Xu; Y.G. Zhu; Z.Q. Tian
06/01/2015
Arg389Gly; Gene; Heart failure; Meta-analysis; Polymorphism; β1 adrenergic receptor

Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, ... more

S.T. Ma; W. Zhao; B. Liu; R.Y. Jia; C.J. Zhao; L.Q. Cui
05/25/2015
Meta-analysis; Monocyte chemoattractant protein-1; Tuberculosis

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The ... more

G. Tian; X. Li; H. Li; X. Wang; B. Cheng
05/25/2015
AGT; Essential hypertension; Meta-analysis; Polymorphism

Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. However, the results have been inconsistent. We examined whether the AGT G-217A gene polymorphism confers essential hypertension risk by conducting a meta-analysis. We conducted a literature search of the Google Scholar, PubMed, and ... more

R. Yao; Y.Y. Du; Y.Z. Zhang; Q.H. Chen; L.S. Zhao; L. Li
05/25/2015
Meta-analysis; Polymorphism; Rheumatoid arthritis; Tumor necrosis factor; Vitiligo

We investigated whether the tumor necrosis factor-a (TNF-α) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-α polymorphisms were determined in RA or vitiligo patients and controls. Meta-analysis was used to ... more

Y.H. Lee; S.C. Bae
05/18/2015
Ankylosing spondylitis; Gene expression; Meta-analysis; Pathway analysis

The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in ankylosing spondylitis (AS). We performed a meta-analysis using the integrative meta-analysis of expression data program on publicly available microarray AS Gene Expression Omnibus (GEO) datasets. We performed Gene Ontology (GO) enrichment ... more

Y.H. Lee; G.G. Song
05/18/2015
Chronic obstructive pulmonary disease; Meta-analysis; Polymorphism; Tumor necrosis factor-alpha

The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify ... more

K. Cui; X.Y. Ge; H.L. Ma
05/11/2015
Glaucoma; Meta-analysis; Polymorphism; TNF-α

The purpose of this study was to examine whether tu­mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex­amining the association between TNF-α -308 A/G and -238 A/G poly­morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The ... more

Y.H. Lee; G.G. Song

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