Research Article

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03/06/2015
AR gene; CAG repeat polymorphism; Isolated hypospadias; Meta-analysis

Studies investigating the association between the CAG repeat polymorphism and the risk of isolated hypospadias have reported conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, CNKI, and Wanfang databases. Weighted mean difference and 95% confidence intervals for the ... more

G. Huang; W. Shan; L. Zeng; L. Huang
02/13/2015
Estrogen receptor alpha; Fracture; Gene polymorphism; Meta-analysis

Numerous studies have evaluated the association between estrogen receptor alpha (ESR1) gene PvuII polymorphism and fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis to examine the association between the ESR1 gene PvuII polymorphism and fracture risk in postmenopausal women. Studies ... more

W. Deng; J.C. Han; L. Chen; W.L. Qi
02/13/2015
B7-H1 expression; Bladder cancer; Meta-analysis

B7 homolog 1 (B7-H1), which is also known as programmed death-L1, is an important member of the B7/CD28 costimulatory factor superfamily, which are emerging as important mediators of various host immune responses. B7-H1 is differentially expressed in various cell subsets and to different extents in human and murine cells. Human B7-H1 is constitutively expressed at low levels in dendritic ... more

Y.U. Wang; A.N.G. Liu; S.H.A.N. Zhao
02/06/2015
CYP1A1; Gene polymorphism; Hepatocellular carcinoma; Meta-analysis

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T>C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and ... more

B.W. Yu; L.Q. Zhang; X.L. Teng; Y. Zhang; L.B. Zou; H.Y. Ying
02/03/2015
Comparative mapping; Genetic map; Integrated linkage map; Maize; Meta-analysis; QTL for disease resistance

We collected data regarding 340 disease resistance quantitative trait loci (QTLs) from the maize genomic database (MaizeGDB). We constructed an integrated linkage map and analyzed this map by using the BioMercator 2.1 software with IBM2 2008 Neighbors genetic linkage map as a reference. We used a meta-analysis method to identify five “consensus” synthetic resistance QTLs located on maize ... more

L. Zhao; H.J. Liu; C.X. Zhang; Q.Y. Wang; X.H. Li
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Gene polymorphism; Interleukin-6; Lung cancer; Meta-analysis

The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the ... more

Y. Liu; X.L. Song; G.L. Zhang; A.M. Peng; P.F. Fu; P. Li; M. Tan; X. Li; M. Li; C.H. Wang
03/11/2013
Differentially expressed genes; Regulation network; Testicular seminoma

Testicular seminoma has become the most common solid malignancy in young men, especially in the 20s group. We obtained the gene expression profile of human testicular seminoma cells from NCBI, identified the differentially expressed genes of testicular seminoma cells of different stages, and constructed the regulation networks of different stages of testicular seminoma using ... more

J.J. Sha; Y.H. Dong; D.M. Liu; J.J. Bo; Y.R. Huang; Z. Li; P. Ping
10/07/2013
CMAP; Differentially expressed genes; Pulmonary hypoxia-related diseases; Similar drugs

Exposure of humans to low levels of environmental oxygen results in alveolar hypoxia and normally causes chronic pulmonary hypertension and morphological alterations of precapillary pulmonary vessels. In this study, the microarray dataset GSE11341 was used to identify potential differentially expressed genes related with human lung microvascular endothelial cell hypoxia. In addition, gene ... more

L. Zhou; L.M. Wang; H.M. Song; Y.Q. Shen; W.J. Xu; J.H. Xu; Y. Liu; W.W. Yan; J.F. Jiang
06/01/2015
Differentially expressed genes; Epstein-Barr virus-positive nasopharyngeal carcinoma; Target genes; Typical miRNAs

This study aims to identify the crucial miRNAs in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC) and their target genes. Gene expression profile data (GSE12452) that included 31 NPC and 10 normal nasopharyngeal tissue specimens were downloaded. Differentially expressed genes (DEGs) were identified using significance analysis of microarrays. The underlying function of DEGs was ... more

L.H. Zhu; X.T. Miao; N.Y. Wang

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