Research Article

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gene fusions; genomic instability; healthy individuals; Leukemia; lymphoma

Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence ... more

M.S. Brassesco
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The ABO blood group is the most important blood group system in transfusion medicine and organ transplantation. To date, more than 160 ABO alleles have been identified by molecular investigation. Almost all ABO genotyping studies have been performed in blood donors and families and for investigation of ABO subgroups detected serologically. The aim of the ... more

M.C.Z. Novaretti; A.E. Domingues; R. Manhani; E.M. Pinto; P.E. Dorlhiac-Llacer; D.A.F. Chamone
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Addiction; Drugs; Heterochromatin; Leukemia; Polymorphism

Heterochromatin is considered to play a role in protecting the genome against mutagens. Changes in the quantity and proportion of different types of satellite DNA could increase genetic susceptibility in individuals with heterochromatic variations; they cause chromosome instability and predispose patients to malignancies. We evaluated the heterochromatin associated with chromosomes in 50 ... more

A. Movafagh; S.A. Mortazavi-Tabatabaei; A.A. Kolahi
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Bioinformatics; Differentially expressed genes; Leukemia

The purpose of this study was to identify differentially expressed genes and analyze biological processes related to leukemia. A meta-analysis was performed using the Rank Product package of Gene Expression Omnibus datasets for leukemia. Next, Gene Ontology-enrichment analysis and pathway analysis were performed using the Gene Ontology website and Kyoto Encyclopedia of Genes and Genomes ... more

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Interactions of microRNA2target; Leukemia; MicroRNA; Target genes

MicroRNAs are small, non-coding RNAs that regulate gene expression by suppressing mRNA translation or inducing mRNA degradation, and have been implicated in a growing number of diseases. To understand microRNAs’ function, it is vital to identify microRNA2target interactions. This work explores the prediction and extraction of leukemia-associated microRNA2target interactions, based on text ... more

L. Gong; Q. Yan; R. Yang; X. Sun
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Cyclin D1 G870A; Hepatocellular carcinoma; Leukemia; Polymorphism; susceptibility

Cyclin D1 (CCND1) is a key protein involved in cell-cycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to clarify these ... more

Y. Zhao; H.R. He; M.Y. Wang; X.D. Ren; L. Zhang; Y.L. Dong; J. Lu
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4-1BBL gene; Cytotoxic T lymphocyte; Dendritic cell; HPSMA gene

This study aimed to examine anti-prostate cancer immune response induced by dendritic cells (DCs) transduced with PSMA/4-1BBL recombinant adenoviruses in vitro. Ad-PSMA, Ad-4-1BBL, and Ad-GFP were transfected into DCs derived from peripheral blood of healthy volunteers. Ad-PSMA/4-1BBL-DC, Ad-PSMA-DC, Ad-4-1BBL-DC, Ad-GFP-DC, and normal-DC, PSMA and 4-1BBL protein levels in DCs ... more

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Dendritic cell; Hepatic sinusoidal endothelial cell; Hepatic stellate cell; Immune; Kupffer cell

The liver is the human body largest digestive and metabolic organ, and a very important immune organ. This paper discusses the location and morphology of hepatic sinusoidal endothelial cells, dendritic cells, hepatic stellate cells, and Kupffer cells in the liver and their role in regulating immune functions. Therefore, here we provide a preliminary understanding of the immune regulatory ... more

X.K. Xing; H.Y. Wu; H.G. Feng; Z.Q. Yuan; X.K. Xing; H.Y. Wu; H.G. Feng; Z.Q. Yuan; X.K. Xing; H.Y. Wu; H.G. Feng; Z.Q. Yuan
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Cytokine gene; IL-10; IL-1β; IL-8; Invasive Candida infection; Polymorphism

The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1βrs16944 ... more

R.T. Sun; W.J. Tian; X.W. Xing; S.H. Gao; S.B. Wang
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Baraclude®; Chronic Hepatitis; IL-10; IL-17; Migratory inhibitory factor

This study aimed to determine the relationship between changes in the serum levels of macrophage migratory inhibitory factor (MIF), interleukin (IL) 17, and IL-10 during chronic hepatitis B treatment via Baraclude® (Bristol-Meyers Squibb). Thirty-six patients with chronic hepatitis B and 24 healthy individuals were selected as the experimental and control groups, respectively, ... more

X.H. Yu; J.C. Zhang; X.Y. Li; T. Chen

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