Research Article

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08/13/2012
Alkalinity stress; Microarray; Oryzias latipes; Transcriptomics

Oryzias latipes (Adrianichthyidae), known as Japanese medaka or Japanese killifish, is a small 2-4 cm long fish common in rice paddies in coastal Southeast Asia and is also a popular aquarium fish. It has been widely used as a research model because of its small size and because it is very easy to rear. Alkalinity stress is considered to be one of the major stressors on fish in ... more

Z.L. Yao; H. Wang; L. Chen; K. Zhou; C.Q. Ying; Q.F. Lai
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Differentially expressed gene; Function enrichment analysis; Microarray; Preadipocytes

We looked for differentially expressed genes at different stages of preadipocyte differentiation and examined their functions, based on DNA microarrays of preadipocytes obtained from healthy subjects undergoing cosmetic liposuction. We downloaded gene expression profile GSE25910 from the Gene Expression Omnibus database and identified the differentially expressed genes with packages in R ... more

J.Y. Du; H. Yang; D.R. Tian; Q.M. Wang; L. He
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Autism; Differentially expressed genes; Expression data; Meta-analysis; Microarray

The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in autism. We performed a meta-analysis using new publicly available Gene Expression Omnibus (GEO) datasets of autism. We performed Gene Ontology (GO) enrichment analyses and pathway analysis using the Kyoto Encyclopedia of Genes and Genomes ( ... more

L.F. Ning; Y.Q. Yu; E.T. GuoJi; C.G. Kou; Y.H. Wu; J.P. Shi; L.Z. Ai; Q. Yu
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L55M polymorphism; Paraoxonase; Q192R polymorphism; Renal cell carcinoma

Increased oxidative stress can help promote carcinogenesis, including development of renal cell carcinoma. The enzyme protects low-density lipoproteins from oxidation and can be a factor in this process. PON1 Q192R and L55M paraoxonase gene polymorphisms were assessed in 60 renal cell carcinoma patients and 60 healthy controls. Genotypes were examined by PCR; the restriction enzyme ... more

O.A. Uyar; M. Kara; D. Erol; A. Ardicoglu; H. Yüce
09/12/2014
Maxillary sinus; Metastasis; Renal cell carcinoma

Metastatic tumors in the paranasal sinuses are very rare. The origin of metastatic tumors in the paranasal sinuses is often renal cancer. Renal cell carcinomas are known for their tendency for early metastasis, and symptoms due to the metastatic lesion may be the only initial manifestation. In this paper, we deal with the case of a 35-year-old male patient who presented with a mass in the ... more

Y.F. He; J. Chen; W.Q. Xu; C.S. Ji; J.P. Du; H.Q. Luo; B. Hu
07/04/2014
Predictive factors; Prognosis; Renal cell carcinoma; VEGF polymorphism

We conducted a study to investigate the possible role of the vascular endothelial growth factor (VEGF) polymorphisms -2578C/A, -1154G/A and -634C/G and clinical factors in renal cell carcinoma (RCC) prognosis in a cohort of 336 RCC cases. A total of 336 patients with RCC were recruited from PLA General Hospital between January 2004 and December 2005. All patients were followed up until ... more

Y.Q. Yang; J. Chen
03/13/2013
MicroRNA network; Osteoarthritis; PPI network; Protein-protein interaction

Osteoarthritis is the most common form of arthritis among elderly adults. Herein, we performed protein-protein interaction (PPI) and miRNA network analysis to evaluate the global correlation between miRNA regulation and the PPI network in human osteoarthritis. Our results showed that desmoplakin (DSP), cystatin A (CSTA), calmodulin 1, tyrosine kinase endothelial, insulin-like growth ... more

M. Wang; C. Liu; Y. Zhang; Y. Hao; X. Zhang; Y.M. Zhang
06/26/2015
cBioPortal; Empirical Bayesian model; Gene interaction; Protein-protein interaction; Scale-free network; Small word network

Recent progress in computational methods for inves­tigating physical and functional gene interactions has provided new insights into the complexity of biological processes. An essential part of these methods is presented visually in the form of gene interaction networks that can be valuable in exploring the mechanisms of disease. Here, a combined network based on gene pairs with an extra ... more

A.M. Zhang; H. Song; Y.H. Shen; Y. Liu

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