Research Article

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03/17/2014
Down syndrome; Folate; MTHFD; Polymorphisms; Transcobalamin gene

We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripheral lymphocytes. Polymerase chain reaction and ... more

Y.P. Liao; D. Zhang; W. Zhou; F.M. Meng; M.S. Bao; P. Xiang; C.Q. Liu
06/12/2015
Chinese raccoon dog; Coat color; EDNRB gene; KIT gene; Polymorphisms

The Chinese raccoon dog (Nyctereutes procyonoides procyonoides) is one of the most important fur-bearing animal species. The dominant white individual, a coat color variant in farmed Chinese raccoon dog, shows a completely white phenotype over the entire body. The KIT and EDNRB genes have been reported to be associated with the dominant white coat color in some ... more

S.Q. Yan; C.Y. Bai; S.M. Qi; M.L. Li; S. Si; Y.M. Li; J.H. Sun
04/13/2015
Ethnic; Infectious disease; Interleukin-10; Interleukin-12B; Malaysia; Polymorphisms

Inheritance of polymorphisms in the interleukin (IL)-10 promoter and IL-12B genes, which influence cytokine production and activities, may define the balance in T helper response in infection and autoimmune diseases. In the present study, we investigated the distribution of the IL-10 promoter and IL-12B gene polymorphisms in a multiethnic Malaysian population. Overall, ... more

S.S. Sam; B.T. Teoh; S. AbuBakar
04/10/2015
Breeding; Hybrid rice; Indels; Polymorphisms; Single nucleotide polymorphisms

Genome-wide re-sequencing of the Zhenshan 97 (ZS97) and Milyang 46 (MY46) parents of an elite three-line hybrid rice developed in China resulted in the generation of 9.91 G bases of data with an effective sequencing depth of 11.66x and 11.51x, respectively. Detection of genome-wide DNA polymorphisms, single nucleotide polymorphisms (SNPs), short insertions/deletions (InDels; 1-5 bp), and ... more

K. Wang; J.Y. Zhuang; D.R. Huang; J.Z. Ying; Y.Y. Fan
03/20/2015
HBV; Hepatocellular carcinoma; MicroRNA; Polymorphisms

We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were genotyped by polymerase chain ... more

D. Li; J.J. Peng; Y. Tan; T. Chen; D. Wei; M. Du; T. Zhang
03/13/2015
Diabetic nephropathy; INSR; mTOR; Polymorphisms; Type 2 diabetes mellitus

We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom ... more

A.N. Zhu; X.X. Yang; M.Y. Sun; Z.X. Zhang; M. Li
02/13/2015
ABCB1; Breast cancer; MDR1; Polymorphisms; Pre- and postmenopausal women

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between ... more

S.A. Gutiérrez-Rubio; A. Quintero-Ramos; A. Durán-Cárdenas; R.A. Franco-Topete; J.M. Castro-Cervantes; A. Oceguera-Villanueva; L.M. Jiménez-Pérez; L.M.A. Balderas-Peña; G. Morgan-Villela; A. Del-Toro-Arreola; A. Daneri-Navarro
02/06/2015
ASIP; Coat color; Copy number variation; Polymorphisms

Tibetan sheep, an indigenous breed, have a wide variety of phenotypes and a colorful coat, which make this breed an interesting model for evaluating the effects of coat-color gene mutations on this phenotypic trait. The agouti signaling protein (ASIP) gene is a positional candidate gene, as was inferred based on previous study. In our research, ASIP gene copy numbers in ... more

J.L. Han; M. Yang; Y.J. Yue; T.T. Guo; J.B. Liu; C.E. Niu; B.H. Yang
01/15/2015
Autoimmune polyglandular syndrome type III; Fyn-binding protein; Polymorphisms; T1DM

The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. We also assessed the role of FYB SNPs in the insurgence of autoimmune polyglandular syndrome type III (APSIII), characterized by the simultaneous presence of autoimmune ... more

C.J.C. Addobbati; deAzevêdo Silva; N.A.C. Tavares; J. Araújo; R.L. Guimarães; L. Brandão; S. Crovella; P. Sandrin-Garcia
11/29/2011
COX; Diabetes mellitus; MMP-9; NF-κB; Resveratrol; SIRT1

Resveratrol (RSV) has a beneficial role in the prevention of diabetes and alleviates some diabetic complications, such as cardiomyopathy. We investigated cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels in heart tissue after RSV treatment in streptozotocin (STZ)-induced diabetic rats. After ... more

A.S. Yar; S. Menevse; E. Alp

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