Research Article

Related GMR Articles

Polymorphisms; Serotonin; Tobacco smoking

Previous studies have revealed a genetic component, including genetic polymorphisms in the serotonergic pathway, particularly in the serotonin receptor gene (5-HT2A). The aim of this study was to investigate associations of the T102C (rs6313) and A-1438G (rs6311) polymorphisms with tobacco use in a population from northeastern Brazil. We evaluated these polymorphisms in 135 ... more

E.S.Ramos Neto; J.O. Mágulas; J.J.S. Sousa; A.C.M. Moura; G.R. Pinto; F.K.N. Yoshioka; R. Canalle; F.J.N. Motta
Colorectal cancer; MicroRNA-27a; Polymorphisms

Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Through genotyping the rs895819 SNP in 254 colorectal cancer (CRC) patients and 238 healthy controls by polymerase chain ... more

Y. Cao; J. Hu; Y. Fang; Q. Chen; H. Li
HCC risk; Hepatocellular carcinoma; miR-149C>T; Polymorphisms

MicroRNAs (miRNAs) are thought to play a role in cancer development. We conducted a case-control study to investigate the association between polymorphisms in miR-149C>T and hepatocellular carcinoma (HCC) risk. Duplex polymerase chain reaction with the confronting 2-pair primers were taken to genotype miR-149C>T. The association between genotype frequencies of miR-149C>T and risk ... more

M.F. Liu; W.Q. Chen; Y.Z. He; Y.L. Gu
Complete linkage disequilibrium; DSG4 gene; Polymorphisms; Sheep; Wool crimp; Wool length

The desmoglein 4 (DSG4) gene is a potential candidate in the search for genes that may affect wool traits, because of its function. This study aimed to screen for polymorphisms in partial exon 16 and 3ꞌUTR of the sheep desmoglein 4 DSG4 gene, and to test its possible association with wool length and crimp associated with fur. Overall, 326 sheep were scanned via ... more

Y.H. Ling; H. Xiang; G. Zhang; J.P. Ding; Z.J. Zhang; Y.H. Zhang; J.L. Han; Y.H. Ma; X.R. Zhang
Hepatocellular carcinoma; MicroRNA; Polymorphisms

We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to ... more

X.H. Wang; F.R. Wang; Y.F. Tang; H.Z. Zou; Y.Q. Zhao
ADAM33; Asthma; CD14; Polymorphisms; TLR4; Uygur population

We evaluated the associations between single nucleotide polymorphisms (SNPs) and haplotypes of the genes encoding a disintegrin and metalloproteinase 33 (ADAM33), cluster of differentiation 14 (CD14), and Toll-like receptor 4 (TLR4) and the susceptibility of developing specific adult phenotypes of bronchial asthma in a Chinese Uygur population. Five SNPs of ... more

J. Wang; M. Simayi; Q. Wushouer; Y. Xia; Y. He; F. Yan; J. Zhang; S. Cui; H. Wen
Glioma; Polymorphisms; Xeroderma pigmentosum complementation group F

We aimed to investigate the role of 4 single nucleotide polymorphisms of the xeroderma pigmentosum complementation group F (XPF) gene (rs3136038, rs1799798, rs1800067, and rs2276466) in glioma, and the roles of gene-gene interactions in the risk of developing this type of cancer. We collected samples from 225 glioma cases and 262 controls and genotyped the rs3136038, rs1799798, rs1800067 ... more

W.K. Zhou; L.Y. Huang; L. Hui; Z.W. Wang; B.Z. Jin; X.L. Zhao; X.Z. Zhang; J.X. Wang; J.C. Wang; R.Z. Wang
Acute myeloid leukemia; Glutathione S-transferase; Polymorphisms

We aimed to investigate the relationships between polymorphisms of the glutathione S-transferases (GSTs) GSTM1, GSTTI, and GSTP1 and the risk of developing acute myeloid leukemia (AML). A total of 206 AML cases and 231 controls were collected for our study. The genotyping of GSTs (GSTM1, GSTTI, and GSTP1) was based upon the duplex ... more

Y.M. Zi; S. Wu; D. Ma; C. Yang; M. Yang; Y. Huang; S.J. Yang
Colorectal cancer; Mexican population; MMP13; MMP7; Polymorphisms

Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms with susceptibility to CRC ... more

J.M. Moreno-Ortiz; M. Gutierrez-Angulo; M. Partida-Pérez; J. Peregrina-Sandoval; R. Ramírez-Ramírez; R. Muñiz-Mendoza; S. Suárez-Villanueva; M. Centeno-Flores; V. Maciel-Gutiérrez; J.E. Cabrales-Vazquez; M.L. Ayala-Madrigal
Breast cancer; Excision repair cross-complimentary group 1; Polymorphisms; susceptibility; Xeroderma pigmentosum complementation group F

Breast cancer is one of the most frequently diagnosed cancer in women worldwide, and we conducted a case-control study by genotyping seven potentially functional SNPs, three in ERCC1 and four in XPF, in a Chinese population of 417 breast cancer cases and 417 cancer-free controls. Three SNPs in ERCC1 and four SNPs in XPF were genotyped by using the Taqman Universal PCR Master Mix in the ... more

X.H. Pei; Z. Yang; X.Q. Lv; H.X. Li