Research Article

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To investigate the effects of different doses of abnormal Savda Munziq on myocardial ischemia-reperfusion injury (MI/RI) in rats with the abnormal Savda syndrome, 50 abnormal Savda animal models were randomly divided into a control group, a model group, a high-dose group, a middle-dose group, and a low-dose group, with each group containing 10 rats. The enzyme-linked immunosorbent assay ... more

A. Maimaitiaili; A. Shabiti; M. Abudureheman; Z. Musha; Q. Jun; G. Maimaitiaili; A. Aibibula; H. Upur
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Cardiovascular protection; Hyperlipidemia; Intermedin; Ischemia-reperfusion injury; Myocardial; Rat

Hyperlipidemia is a well-established risk factor for the development of coronary atherosclerosis, while intermedin (IMD) has been identified as a novel calcitonin/calcitonin gene-related peptide family member involved in cardiovascular protection. However, whether IMD protects against hyperlipidemia-associated myocardial ischemia/reperfusion (MI/R) injury is unknown. We established a ... more

S.M. Yang; J. Liu; C.X. Li
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To explore the mechanism whereby stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) jointly mobilize bone marrow stem cells (BMSCs) and promote kidney repair, male Sprague-Dawley rats were randomly assigned into 4 groups. In the treatment control group, rats were administered SCF (200 μg·kg-1·day-1) and G-CSF (50 μg·kg-1·day-1) for 5 days. In ... more

L.Y. Bi; D.A. Zhao; D.S. Yang; J.G. Guo; B. Liang; R.X. Zhang; J.L. Zhao; H.T. Bai; S.J. Li
12/19/2013
Cyclosporine A; Liver transplantation; Th1/Th2

In this study, early expressions of peripheral blood Th1 and Th2 cells were documented following rat liver transplantation and related to immune status. Rats were divided into 3 groups: group A (control): syngeneic transplantation (Brown Norway (BN) → BN); group B: allogeneic transplantation + cyclosporine A (CsA); group C: allogeneic transplantation (Lewis → BN). Flow cytometry was used ... more

Z.L. Yang; K. Cheng; H.G. Sun; W.W. Zou; M.M. Wu
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Interleukin-10; Liver regeneration; Liver transplantation; Tumor necrosis factor

To study the impact of cold ischemia on tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) expression after liver transplantation, a stable model of partial liver transplantation in rats was established. The experimental animals were divided into the following groups: a partial hepatectomy control group, a group that received partial liver transplantation after 30 min of cold ... more

Q.A. Qi; Z.Y. Yang; K.S. Ma; Q. Lu; S.G. Wang; X.W. Li; F. Xia; W. Liu; P. Bie
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Aspergillosis; Cytokines; Liver transplantation; Treg cells

Infection is the leading risk factor of liver transplantation-related death. Aspergillosis is a life-threatening complication in immune-compromised patients, and is the cause of approximately 2/3 of deaths in liver transplant recipients. In our previous studies, we found a regulatory T cell (Treg) population that showed significantly increased immune tolerance in Aspergillus- ... more

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Cytochrome P450 3A5; Liver transplantation; Renal toxicity; Tacrolimus; Transplant rejection

We evaluated the clinical efficacy of tailoring tacrolimus dosage to cytochrome P450 (CYP) 3A5 genotype in liver transplant patients. One hundred patients who received tacrolimus-based therapy were included in the retrospective study in which the relationship between the tacrolimus blood trough concentration/dosage ratio and the CYP3A5 genotype of both donors and recipients was determined ... more

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11/22/2013
Cytokines; Gold nanoparticles; In vivo toxicity; Inflammation; Rats

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute ... more

H.A. Khan; M.A.K. Abdelhalim; A.S. Alhomida; M.S.Al Ayed
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Interleukin; Peroxisome proliferator-activated receptor; Rats; Tumor necrosis factor-α

The objective was to study peroxisome proliferator-activated receptor gamma (PPARγ) agonist pioglitazone regulation effect and its mechanism of expression of cytokines on acute gouty arthritis synovial in rats. Rats with unilateral ankle were injected with artificial monosodium urate (MSU) crystals to make the acute gouty arthritis model. Taking the synovium 48 h after the injection of ... more

R.C. Wang; D.M. Jiang
06/18/2014
Hirudin; Intracerebral hemorrhage; Rats; Thrombin

This study aimed to investigate the effects of thrombin released in hematoma after intracerebral hemorrhage (ICH) on the cerebral injury of perihematomal tissues and to evaluate the protection effect of hirudin on the cerebral injury after ICH. We used the autologous uncoagulated blood injection method to prepare the ICH rat model, and all rats were randomly divided into a normal group, ... more

C.M. Liu; B.Z. Shi; J.S. Zhou

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