Research Article

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05/10/2011
Coronary artery disease; Cox-2 (-765G > C); Diabetes mellitus; IL-6; Polymorphism

Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now known to be an inflammatory process mediated by prostaglandins and several interleukins. As both are important in inflammatory processes, we examined Cox-2 (-765G > C ... more

K.K. Ol; B. Agachan; U. Gormus; B. Toptas; T. Isbir
07/13/2010
Coronary artery disease; Inflammation; Polymorphism; PPAR-δ

Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences the risk of CAD in the absence of dyslipidemia was not known, so we ... more

I. Jguirim-Souissi; A. Jelassi; Y. Hrira; M. Najah; A. Slimani; F. Addad; M. Hassine; K.B. Hamda; F. Maatouk; M. Rouis; M.N. Slimane
09/23/2013
Coronary artery disease; Meta-analysis; Polymorphism

The G403A polymorphism in the RANTES (regulated on activation normal T cell expressed and secreted) gene has a key role in the expression of RANTES, which has been detected in a range of cells in atherosclerotic plaque. However, the association of this polymorphism with the risk of coronary artery disease (CAD) remains controversial. A meta-analysis was performed to assess the association ... more

K. Cui; X.Y. Ge; H.L. Ma
08/31/2012
11β-hydroxysteroid dehydrogenase type 1; Ascending aorta; Coronary artery disease; Epicardial adipose tissue; Glucocorticoids; Metabolic syndrome

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) activity and mRNA levels are increased in visceral and subcutaneous adipose tissues of metabolic syndrome subjects. We analyzed 11β-HSD-1 expression in human epicardial adipose (EA) and ascending aorta (AA) tissues of metabolic syndrome patients and examined their contribution to the development of coronary atherosclerosis. The 11β-HSD- ... more

F. Atalar; B. Vural; C. Ciftci; A. Demirkan; G. Akan; B. Susleyici-Duman; D. Gunay; B. Akpinar; E. Sagbas; U. Ozbek; A.S. Buyukdevrim
11/11/2014
Coronary artery disease; Gensini score; Neutrophil-to-lymphocyte ratio

This study aimed to investigate the relation between the neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary artery stenosis. A total of 219 patients were included in the study, comprising 51 coronary artery atherosclerosis (CAC) patients, 92 stable angina pectoris (SAP) patients, and 76 acute coronary syndrome (ACS) patients. Based on the results of coronary angiography, ... more

G.Y. Zhang; M. Chen; Z.M. Yu; X.D. Wang; Z.Q. Wang
10/20/2014
Coronary artery disease; Gene mutation; MEF2A; Polymorphism

We investigated mutations and polymorphisms of the coronary artery disease (CAD)-related myocyte enhancer factor 2A (MEF2A) gene in a Chinese population. Polymerase chain reaction-single-strand conformation polymorphism and DNA sequencing were used to detect exon 11 of the MEF2A gene in 210 Hubei patients with CAD and 190 healthy controls. The following mutations were ... more

J. Li; H.X. Chen; J.G. Yang; W. Li; R. Du; L. Tian
09/26/2014
Case-control study; Chinese population; Coronary artery disease; Interleukin-6

We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C ... more

G.Q. Sun; G.D. Wu; Y. Meng; B. Du; Y.B. Li
04/08/2014
Coronary artery disease; Genotyping; Polymorphism; Predisposing genes; Single nucleotide

This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chi­nese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han or­igin as controls. The SNP genotypes were performed by ... more

Y.H. Liu; Y.W. Zhou; J.A. Yang; Z.G. Tu; S.Y. Ji; Z.Y. Huang; Z.J. Zhou
03/24/2014
Atorvastatin; Cholesterol ester transfer protein; Coronary artery disease; Gene

This study aimed to investigate the relationship between the cholesterol ester transfer protein (CETP) gene TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease. Two hundred eighty-eight patients were divided into a control group, an acute coronary syndrome (ACS) group, and a stable coronary heart disease (CHD) ... more

J. Li; L. Zhang; N.Z. Xie; B. Deng; L.X. Lv; L.Q. Zheng
03/06/2014
Coronary artery disease; Meta-analysis; PTGS2

Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conducted a search of case-control studies on the ... more

C.L. Xuan; W. Yan; L. Xuan; R.H. Xu

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