Research Article

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Alzheimer’s disease; Amyloid β protein; Axon; Curcumin; NGR

Curcumin has been widely used for the prevention and treatment of Alzheimer's disease (AD), but its mechanism is still not clear. Inhibitory factors of axonal regeneration have been shown to cause a series of pathophysiological changes in the early period of AD. In this study, the co-receptor (Nogo receptor; NgR) of three axonal growth-inhibitory proteins was examined, and effects of ... more

H.L. Yin; Y.L. Wang; J.F. Li; B. Han; X.X. Zhang; Y.T. Wang; S. Geng
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Apoptosis; Curcumin; Invasion; Melanoma; Migration; Proliferation

Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentrations of curcumin. We ... more

Y.P. Zhang; Y.Q. Li; Y.T. Lv; J.M. Wang
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Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Colorectal neoplasms; Curcumin; Drug Resistance, Neoplasm; Heat-shock proteins; HSP27 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Molecular chaperones; Proto-Oncogene Proteins c-bcl-2; Survivin

Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combination with curcumin on HCT-8/5 ... more

Y.X. Fan; P. Abulimiti; H.L. Zhang; Y.K. Zhou; L. Zhu
04/30/22
Antioxidant effect; Curcumin; Diabetic nephropathy; Phytochemical agent

This study aimed to examine the effects of curcumin, a phytochemical antioxidant, on the treatment and care of diabetic nephropathy and to contribute to alternative treatment strategies for diabetes. Male Wistar albino rats (8–10 weeks old) were divided into five groups of seven. Experimental diabetes was induced in all rats except for those in Group 1 (placebo ... more

C.D. Arican; G.S. Gokdemir; M.T. Gokdemir; B. Yokus; E. Tasdemir; A. Sermet
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Dexamethasone; Secondary lymphoid tissue chemokine; Triptolide; Ulcerative colitis

The secondary lymphoid tissue chemokine (CCL21) is closely associated with lymphoid homing and anti-tumor immune responses. CCL21 also has a chemotactic effect on intestinal lymphocytes. This study mainly focused on CCL21 expression in experimental ulcerative colitis and on the effects of CCL21 suppression on this disease in mice. The mouse colitis model was induced by dextran sulfate ... more

H. Zhang; X. Zhang; X. Ding; W. Cao; L. Qu; G. Zhou
04/03/2014
Polymorphism; STAT3 gene; Ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammation of the large intestine. The aim of this study was to investigate the association of two polymorphisms in STAT3 with the risk of UC development in the Chinese Han population. This is a hospital-based case-control study involving 56 UC patients and 274 controls. Genotyping was performed using the polymerase chain reaction with ... more

L. Wang; Z.T. Wang; H.X. Zhang; J. Liu; S.Y. Lu; R. Fan; J. Zhou; L. Xia; Y.W. Sun; J. Zhong; Y.Z. Yuan
08/28/2015
CD4+CD45+ regulatory T cells; Flow cytometry; Immune regulation; Ulcerative colitis

The objectives of this study were to explore the expression of peripheral blood CD4+CD45+ T cells in patients with ulcerative colitis (UC) and determine its clinical value. We selected 80 patients with UC from the First Affiliated Hospital of Liaoning Medical University from March 2012 to December 2013. Of these, 27 had mildly active, 28 moderately active, and 25 severely active UC. We also ... more

L.Y. Guo; Y.R. Li; X.P. Jin