Research Article

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03/24/2014
Gastric cancer; Haplotype analysis; Methylenetetrahydrofolate reductase; susceptibility

Epidemiological studies have indicated that folate metabolism is correlated with increased risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer. The polymorphisms MTHFR C677T and ... more

J. Lin; R.M. Zeng; R.N. Li; W.H. Cao
04/27/2015
Ischemic stroke; Methylenetetrahydrofolate reductase; Polymorphism

The association between the MTHFR genetic polymorphism and ischemic stroke has been reported by a number of investigators. However, the results have been controversial and conflicting. The aim of this study was to explore the association between the MTHFR variants C677T and A1298C and the risk of ischemic stroke in an Eastern Chinese Han population. A total of 199 ... more

Q.Q. Lv; J. Lu; H. Sun; J.S. Zhang
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Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Psoriasis

Previous studies investigating the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphisms and psoriasis risk have reported inconsistent results. The present meta-analysis aimed to comprehensively evaluate the association between MTHFR 677C/T polymorphism and psoriasis risk. The studies regarding the association between MTHFR 677C/T ... more

J.H. Qi; N. Shi; Y.J. Chen; G. Nie
10/25/2011
Congenital heart defect; Folic acid; Homocysteine; Methionine synthase reductase; Polymorphisms

Congenital heart defects (CHDs) are the most common birth defects; genes involved in homocysteine/folate metabolism may play important roles in CHDs. Methionine synthase reductase (MTRR) is one of the key regulatory enzymes involved in the metabolic pathway of homocysteine. We investigated whether two polymorphisms (A66G and C524T) of the MTRR gene are associated with ... more

W. Zeng; L. Liu; Y. Tong; H.M. Liu; L. Dai; M. Mao
11/30/2010
Bone mineral density; Bone morphogenetic protein 2 and 4; Genetic association; Osteoporosis; Single-nucleotide polymorphism

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women with positive bone mineral density scores. We evaluated the ... more

Z.S. Özkan; D. Deveci; E. Önalan; H. Yüce
12/14/2010
Cloning; Litopenaeus vannamei; Ryanodine receptor; Single-nucleotide polymorphism

Ryanodine receptor/calcium release channel is a large protein that plays an essential role in muscle contraction; mutations in the ryanodine receptor gene affect sensitivity to stress. As a first step towards investigating the relationship between the ryanodine receptor and shrimp cramped muscle syndrome, we cloned, partially sequenced, and examined single-nucleotide polymorphisms (SNPs) ... more

X.H. Chen; D.G. Zeng; N. Ma
08/03/2010
Chinese Han population; Rheumatoid arthritis; Single-nucleotide polymorphism; Suppressor of cytokine signaling-3 (SOCS-3)

Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter region of SOCS-3 and rheumatoid arthritis (RA) in a ... more

L.P. Sun; X.L. Ma; H.X. Liu; Y.S. Wang; X.F. Li
09/19/2013
Association analysis; Multidrug resistance 1 gene; Prostate cancer; Risk factors; Single-nucleotide polymorphism

Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were ... more

F.R. Shen; C.Y. Yan; M. Liu; Y.H. Feng; Y.G. Chen
08/13/2012
High-throughput sequencing; Pepper; Single-nucleotide polymorphism; Single-sequence repeats; Transcriptome

Genetic markers based on single nucleotide polymorphisms (SNPs) are in increasing demand for genome mapping and fingerprinting of breeding populations in crop plants. Recent advances in high-throughput sequencing provide the opportunity for whole-genome resequencing and identification of allelic variants by mapping the reads to a reference genome. However, for many species, such as pepper ... more

M. Nicolaï; C. Pisani; J.P. Bouchet; M. Vuylsteke; A. Palloix
06/10/2015
Chicken; GRP78 gene; Heat stress; Quantitative real-time PCR; Single-nucleotide polymorphism

Glucose-regulated protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum and can be induced by different kinds of environmental and physiological stress. Thus far, the role of the GRP78 gene in thermotolerance in chickens has not been investigated. In the present study, we detected sequence variations in the 5ꞌ-flanking region of the GRP78 gene and ... more

L.N. Kong; D.X. Zhang; C.L. Ji; X.Q. Zhang; Q.B. Luo

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