Research Article

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09/10/2013
Epithelial ovarian cancer; Gene expression; Nuclear factor-kappa B; Polymorphism; β-transducin repeat-containing protein

Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -94 ins/del ATTG polymorphism in the promoter region of ... more

Z.H. Huo; H.J. Zhong; Y.S. Zhu; B. Xing; H. Tang
09/03/2013
Genetic relationship; Lolium; Polymorphism; RAPD markers; Taxonomy

The genus Lolium is one of the most important groupings of temperate forage grasses, including about eight recognized species that are native to some temperate and subtropical regions of the northern hemisphere. We examined genetic relationships among 18 accessions representing all Lolium species using RAPD markers. Among 50 random primers that we screened, 13 gave ... more

X. Ma; X.Y. Gu; T.T. Chen; S.Y. Chen; L.K. Huang; X.Q. Zhang
07/08/2013
Endothelial nitric oxide synthase; Intervertebral disc degeneration; Polymorphism; Vascular endothelial growth factor

Disturbances in blood flow to intervertebral discs (IVD) play an important role in IVD degeneration. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) are extremely important angiogenic factors for vasodilation and neovascularization. We investigated the relationship between single nucleotide polymorphisms (SNPs) of the VEGF and eNOS ... more

I.B. Han; A.E. Ropper; Y.D. Teng; D.A. Shin; Y.J. Jeon; H.M. Park; D.E. Shin; Y.S. Park; K.N. Kim; N.K. Kim
07/08/2013
Association signal; Colorectal cancer; IL6 gene; Meta-analysis; Polymorphism

Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studies on the role of ... more

J.J. Hu; Z.T. Wang; J. Zhong
07/08/2013
Polymorphism; Saudi; Tumor necrosis factor; Vitiligo

Vitiligo is an acquired depigmentary disorder of the skin, characterized by multiple susceptibility loci and genetic heterogeneity. The etiology of vitiligo is unknown but several hypotheses, including an autoimmune origin, have been proposed. Tumor necrosis factor (TNF)-α, a pleiotropic proinflammatory cytokine, has been shown to play a critical role in several autoimmune diseases ... more

F. Al-Harthi; A. Zouman; M. Arfin; M. Tariq; A. Al-Asmari
07/04/2013
Growth differentiation factor 9; Holstein bulls; Polymorphism; Sperm quality

Members of the transforming growth factor-β (TGFβ) superfamily are critical regulators of germ cell development that act as extracellular ligands of the signal transduction pathways regulating proliferation, differentiation, apoptosis, and other aspects of cell behavior. Growth differentiation factor 9 (GDF9) is a member of the TGFβ superfamily that plays a critical role in ovarian ... more

K.Q. Tang; W.C. Yang; X.X. Zhang; L.G. Yang
07/15/2013
Leptin; Leptin receptor; Polymorphism; Preeclampsia

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and ... more

S. Wang; F.Y. Qiao; L. Feng
05/14/2013
5-Lipoxygenase activating protein; Cerebral infarction; Cyclooxygenase; Genetics; Polymorphism

We made a case-control study to investigate a possible association between ALOX5AP-SG13S114A/T, COX-2-765G/C, and COX-1-50C/T polymorphisms with cerebral infarction in a Chinese population. A total of 411 cases with cerebral infarction were included; 411 controls matched for age, gender, and risk factors were also selected. The ... more

X.Y. Yi; Q. Zhou; J. Lin; L.F. Chi; W.Z. Chi
05/14/2013
Association risk; Coronary artery stenosis; KLK1 A1789G gene; Polymorphism

Previous reports have shown that polymorphism of the human tissue kallikrein 1 (KLK1) A1789G gene is associated with susceptibility to hypertension. The current study aimed to confirm the association between the polymorphism in KLK1 and coronary artery stenosis (CAS). A total of 458 patients with CAS and 482 controls were used in a case-control study carried out between ... more

Q.D. Li; F.J. Li; X.C. Liu; H. Jiang
06/11/2013
GNAQ; Han Chinese population; Polymorphism; Rheumatoid arthritis

Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activ­ity. These indicate that Gαq plays critical roles in the ... more

Y. Li; Y. Wang; Y. He; D. Wang; L. Deng; Y. Du; G. Shi

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