Research Article

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06/11/2010
Breast cancer; Drug therapy; Genetic; Glutathione transferase; Polymorphism

The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant ... more

A.L. Oliveira; F.F.O. Rodrigues; R.E. Santos; T. Aoki; M.N. Rocha; C.A. Longui; M.B. Melo
01/12/2010
Breast cancer; C3435T polymorphism; MDR1 gene; Multidrug resistance; Real-time polymerase chain reaction

One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports many hydrophobic substrates and anti-cancer drugs out of the cell ... more

M. Taheri; F. Mahjoubi; R. Omranipour
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Breast cancer; C-erbB-2; CCR5; Immunohistochemistry; Ki-67; Prognostic indicator

We designed a 2-stage study to investigate chemotactic factor receptor 5 (CCR5) gene expression in breast cancer tissues and axillary lymph nodes and analyze the association between the CCR5-Δ32 gene polymorphism and the clinical features and prognosis of breast cancer patients. The first stage examined 72 cases of invasive ductal carcinoma and axillary lymph ... more

Y. Zhang; F.Y. Meng; W.L. Li; C.X. Zhou; Z. Guan; H.Y. Fan
01/04/2013
Breast cancer; Chromosome 17; FISH; Metastasis; TP53 gene

Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor gene TP53, located at 17p13 ... more

D.S. Vasconcelos; F.P.E. da Silva; L.G. Quintana; N.P. Anselmo; M.A.K. Othman; T. Liehr; E.H.C. de Oliveira
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Breast cancer; Chinese Han population; MHC class-III; Single nucleotide polymorphism

Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried out a hospital-based case-control ... more

Q. Pan; Y. Ning; L.Z. Chen; S. Zhang; Z.Z. Liu; X.X. Yang; W. Wei; H. Wei; Q.G. Li; H.N. Yue; J.X. Wang
11/28/2012
Biomarker; Breast cancer; Human mammaglobin; Prognostic factor

Different treatment outcomes and prognoses in patients with breast cancer can be observed with similar clinical predictors; this is because the biology of breast cancer is complex and heterogenous, involving multiple unknown contributing factors. We looked for plasma human mammaglobin (hMAM) mRNA by RT-PCR in 82 Korean patients with breast cancer to determine if there is an association ... more

G.W. Lee; J.Y. Kim; E.H. Koh; D. Kang; D.S. Choi; K.Y. Maeng; J.S. Lee
01/13/2012
Breast cancer; Migration; NM23H1; Sodium valproate

Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproate on breast cancer are insufficient in both animals and ... more

G.F. Li; T.L. Qian; G.S. Li; C.X. Yang; M. Qin; J. Huang; M. Sun; Y.Q. Han
12/04/2014
Breast cancer; Pathway; Survival analysis

Breast cancer remains the second largest cause of death in women from cancer. By analyzing gene expression profiles in samples from breast cancer patients, 844 differentially expressed genes (DEGs) were identified in breast cancer metastasis. The 10 most significant signaling pathways identified through enrichment analysis contained DEGs were involved in oxidative phosphorylation, DNA ... more

J.Z. Wu; T.J. Yang; P. Lu; W. Ma
09/26/2014
Breast cancer; Genes; HER-2; Magnetic resonance imaging

The aim of this study was to investigate the correlation between apparent diffusion coefficients (ADCs), the relative apparent diffusion coefficient (rADC), and the pathological prognostic factor human epidermal growth factor receptor 2 (HER-2) in patients with breast cancer. A total of 64 women with breast cancer underwent breast diffusion-weighted imaging. HER-2 expression was detected ... more

X.Y. Jiang; Q.Z. Xie; X.S. Cao; T. Gao; C.Y. Xing; X.L. Li
09/29/2014
Breast cancer; Differentially expressed genes; Gene coexpression network analysis; Pathway analysis

The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed genes (DEGs) between breast cancer and normal control were ... more

J.L. Huan; X. Gao; L. Xing; X.J. Qin; H.X. Qian; Q. Zhou; L. Zhu

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