Research Article

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Variants in the C-reactive protein (CRP) gene have been found to be associated with various phenotypic traits. We evaluated the effect of four SNPs in the CRP gene on serum levels of protein and body mass index (BMI) in 150 unrelated Mexican subjects from 18 to 25 years old, without hypertension, non-overweight, and without inflammatory diseases, non-smoking and non- ... more

E. Flores-Alfaro; G. Fernández-Tilapa; E. Salazar-Martínez; M. Cruz; B. Illades-Aguiar; I. Parra-Rojas
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C-reactive protein; Inflammatory reaction; Intracerebral hemorrhage; Polymorphism; Resistin

We examined a possible relationship -420C>G SNP of the resistin gene with plasma resistin and C-reactive protein concentrations in intracerebral hemorrhage. Three hundred and forty-four Chinese Han patients with intracerebral hemorrhage and 344 age- and gender-matched healthy controls were included in our study. Plasma resistin and C-reactive concentrations were measured and SNP -420C ... more

X.Q. Dong; Q. Du; W.H. Yu; Z.Y. Zhang; Q. Zhu; Z.H. Che; H. Wang; J. Chen; S.B. Yang; J.F. Wen
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Immunohistochemistry; Interleukin-8; Mammary cancer; Prognosis; Real-time PCR

The use of prognostic markers for mammary cancer is important for routine diagnosis and research. Interleukin-8 (IL-8) is a chemotactic cytokine, produced by several cell types in response to inflammation. The expression, regulation and function of IL-8 in dogs are little known. Recent studies have associated angiogenesis and inflammatory processes with tumor malignancy. We investigated a ... more

D.A.P.C. Zuccari; R. Castro; G.B. Gelaleti; U.M. Mancini
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BRAF gene; Denaturing high-performance liquid chromatography; Multiplex allele-specific PCR; Prognosis; V600E mutation

Mutations in the V-raf murine sarcoma viral oncogene homolog B1 gene (BRAF) play an important role in the pathogenesis of papillary thyroid cancer (PTC). In this study, a BRAF V600E mutation was detected in formalin-fixed and paraffin-embedded PTC samples using multiplex allele-specific polymerase chain reaction and denaturing high-performance liquid chromatography. The ... more

R.X. Gong; Y.P. Gong; J. Yang; T. Wei; J. Li-Ling; J.Q. Zhu
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Immunohistochemistry; Mammary cancer; Prognosis; Quantitative PCR

Caveolin-1 (Cav-1) is a structural protein present in invaginations of the cell membrane. In human breast cancer, the cav-1 gene is believed to be a tumor suppressor gene associated with inhibition of tumor metastasis. However, little is known about its expression, regulation and function in canine mammary tumors. Expression levels of cav-1 were investigated using real- ... more

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Gastric cancer; Meta-analysis; Prognosis; S100A4

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Y. Wang; L.B. Zhou; X.H. Li
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Acute lymphoblastic leukemia; Adolescent; Child; Myeloid anomalous expression; Platelet count; Prognosis

The aim of this study was to evaluate myeloid expression in acute lymphoblastic leukemia (ALL) in children and adolescents who had been referred to the Oncology Department in a hospital in the State of Maranhão based on demographic, laboratory, and clinical data. Myeloid expression was evaluated in 65 patients under 18 years of age who were diagnosed with morphological, cytochemical, and ... more

T.C. Lopes; K.N.S. Andrade; N.L. Camelo; V.P. Rodrigues; R.A.G. Oliveira
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Advanced oxidation protein products; Biomarker; Case-control study; Cutaneous lupus erythematosus; Lupus nephritis; Prognosis

Oxidative stress is involved in the pathogenesis of lupus nephritis (LN). The current study investigated the significance of advanced oxidation protein products (AOPPs) as a biomarker of LN in patients with cutaneous lupus erythematosus. Ninety-two patients who initially presented with systemic lupus erythematosus were divided into the LN- and LN+ groups. Serum AOPP levels were determined ... more

Z. Xie; M. Zhang; B. Zhao; Q. Wang; J. Li; Y.Y. Liu; Y.H. Chen
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Ezrin; Laryngeal squamous cell carcinoma; Metastasis; Moesin; Prognosis

We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) and their correlation with patient clinicopathological characteristics and overall survival. Immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) for ezrin and moesin were applied to 60 carcinoma tissues, adjacent normal tissues, and 33 metastatic lymph nodes. ... more

X. Wang; M. Liu; C.Y. Zhao

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