Research Article

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05/18/2015
Korean native pig; MHC class I; Single nucleotide polymorphism; SLA-3

We investigated the phylogenetic relationships between pig breeds, compared the genetic similarity between humans and pigs, and provided basic genetic information on Korean native pigs (KNPs), using genetic variants of the swine leukocyte antigen 3 (SLA-3) gene. Primers were based on sequences from GenBank (accession Nos. AF464010 and AF464009). Polymerase chain reaction analysis ... more

H.Y. Chung; Y.C. Choi; H.N. Park
05/18/2015
Average daily gain; Beef cattle; Feed efficiency; Genome-wide association study; Nellore; Single nucleotide polymorphism

Weight gain is a key performance trait for beef cat­tle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on per­formance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and ge­nomic regions associated with residual body weight gain (RWG), we ... more

M.H.A. Santana; R.C. Gomes; Y.T. Utsunomiya; H.H.R. Neves; F.J. Novais; M.N. Bonin; H. Fukumasu; J.F. Garcia; P.A. Alexandre; G.A.Oliveira Junior; L.L. Coutinho; J.B.S. Ferraz
05/04/2015
let-7; Lung cancer; Single nucleotide polymorphism; susceptibility

Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes in gene function. In this study, we ... more

L.Q. Shen; Y.Z. Xie; X.F. Qian; Z.X. Zhuang; Y. Jiao; X.F. Qi
04/27/2015
Cleaved amplified polymorphic sequence (CAPS); endo-PG gene; Haplotype; Insertion/deletions (indels); Single nucleotide polymorphism

Single nucleotide polymorphisms (SNPs) are the most abundant sequence variations found in plant genomes and are widely used as molecular genetic markers in genetic diversity studies and crossbreeding programs. In this study, we examined 113 DNA sequences of the endopolygalacturonase (endo-PG) gene from 67 peach accessions and found a total of 56 SNPs and 6 insertion/deletions ( ... more

Y. Jiao; R. Ma; M. Yu
04/27/2015
Adiponectin gene; Atherosclerotic cerebral infarction; Polymorphism; Single nucleotide polymorphism; Stroke

We investigated the association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction (ACI) in a Chinese Han population of Hainan Province. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to analyze the distribution of APM-1 +45T/G and +276G/T genotypes and their alleles in 120 ACI ... more

P. He; X.L. Chen; Y.P. Ding
04/17/2015
Cancer; DNA (cytosine-5)-methyltransferase 3A; Meta-analysis; Single nucleotide polymorphism

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies ... more

C.H. Liu; T. Tao; L. Jiang; B. Xu; L. Zhang; K. Lu; X.W. Zhang; S.Q. Chen; D.C. Liu; M. Chen
04/17/2015
Body measurement traits; Meat quality traits; PRKAG2; Qinchuan cattle; Single nucleotide polymorphism

Body measurement and meat quality traits play important roles in the evaluation of productivity and economy in cattle, which are influenced by genes and environmental factors. PRKAG2, which encodes the γ2 regulatory subunit of AMPK, is associated with key metabolic pathways in muscle. We detected bovine PRKAG2 gene polymorphisms and analyzed their associations with body ... more

C.Z. Fu; W.Q. Tian; Y.K. Li; S.J. Wei; G. Cheng; H.B. Wang; L.S. Zan
04/15/2015
MutS homolog 3; Non-small cell lung cancer; Platinum-based chemotherapy; Single nucleotide polymorphism

Mismatch repair (MMR) genes, as well as the nucleotide excision repair genes, play an important role in removing cisplatin-DNA adducts, and the mutation of MMR genes in tumors can lead to a decreased response to platinum-based therapies. We examined MutS homolog 3 (MSH3), a mismatch repair gene, and whether polymorphisms of MSH3 were associated with response and survival in advanced non- ... more

X.L. Xu; Y.L. Yao; W.Z. Xu; J.G. Feng; W.M. Mao
04/10/2015
Diabetes mellitus; GAD-Ab; Glutamic acid decarboxylase 2; Single nucleotide polymorphism

In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid de­carboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untranslated region ( ... more

Q. Li; Z.R. Qiao; D.B. Liu; J.T. Zeng; J. Zhang; Y. Bo; H.Y. Zu; Q. Hu; X. Wu; S.S. Dong
03/31/2015
Asthma; Meta-analysis; Polymorphism; Single nucleotide polymorphism

The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R ... more

Z.Y. Huang; B.J. Cheng; G.J. Cai; B.F. Zhang

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