Research Article

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We investigated the phylogenetic relationships between pig breeds, compared the genetic similarity between humans and pigs, and provided basic genetic information on Korean native pigs (KNPs), using genetic variants of the swine leukocyte antigen 3 (SLA-3) gene. Primers were based on sequences from GenBank (accession Nos. AF464010 and AF464009). Polymerase chain reaction analysis ... more

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Average daily gain; Beef cattle; Feed efficiency; Genome-wide association study; Nellore; Single nucleotide polymorphism

Weight gain is a key performance trait for beef cat­tle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on per­formance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and ge­nomic regions associated with residual body weight gain (RWG), we ... more

M.H.A. Santana; R.C. Gomes; Y.T. Utsunomiya; H.H.R. Neves; F.J. Novais; M.N. Bonin; H. Fukumasu; J.F. Garcia; P.A. Alexandre; G.A.Oliveira Junior; L.L. Coutinho; J.B.S. Ferraz
let-7; Lung cancer; Single nucleotide polymorphism; susceptibility

Lung cancer is a complex polygenic disease and many genetic factors are involved in the development of the disease. As one of the most important and widely studied families of microRNA, let-7 appears to play an important role in initiation and progression of lung cancer. Any small changes in miRNA level or its target point can cause significant changes in gene function. In this study, we ... more

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Cleaved amplified polymorphic sequence (CAPS); endo-PG gene; Haplotype; Insertion/deletions (indels); Single nucleotide polymorphism

Single nucleotide polymorphisms (SNPs) are the most abundant sequence variations found in plant genomes and are widely used as molecular genetic markers in genetic diversity studies and crossbreeding programs. In this study, we examined 113 DNA sequences of the endopolygalacturonase (endo-PG) gene from 67 peach accessions and found a total of 56 SNPs and 6 insertion/deletions ( ... more

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Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies ... more

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Body measurement and meat quality traits play important roles in the evaluation of productivity and economy in cattle, which are influenced by genes and environmental factors. PRKAG2, which encodes the γ2 regulatory subunit of AMPK, is associated with key metabolic pathways in muscle. We detected bovine PRKAG2 gene polymorphisms and analyzed their associations with body ... more

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The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R ... more

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