Research Article

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Asian; Cancer; Single nucleotide polymorphism; Vascular endothelial growth factor

Vascular endothelial growth factor (VEGF), the most important regulator of angiogenesis and vascular permeability, is involved in various steps of carcinogenesis. The +936C/T polymorphism of the VEGF gene has been reported to affect the VEGF protein level and to be related to the susceptibility of cancer. However, the results of published studies, as well as the subsequent meta-analyses, ... more

X.L. Liu; Q.F. Yang; B.H. Kong
06/21/2013
Angiotensin II type 1 receptor; Angiotensin receptor blocker; Essential hypertension; Single nucleotide polymorphism

The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1 receptor are associated with ... more

H.T. Gong; X.L. Ma; B.X. Chen; X.Y. Xu; Q. Li; C.X. Guo; F.H. Du
01/30/2013
Intramuscular fat; Intron 1; L-FABP; Marbling; Single nucleotide polymorphism; Swine

This study was designed to investigate a single nucleotide polymorphism in intron 1 of the liver fatty acid-binding protein (L-FABP) gene in 156 Junmu No. 1 white swine using PCR-single-strand conformational polymorphism. The association between the polymorphism and meat quality traits was also studied. The cloning and sequencing results indicated that the polymorphism in intron ... more

Y.H. Zhang; L.S. Dai; T.H. Ma; S.Z. Wang; J. Guo; F.J. Li; S.M. Zhang; B.X. Sun; D.F. Liu; Y. Gao; J.B. Zhang
01/22/2013
High-resolution melting analysis; Lung cancer; Non-small cell lung cancer; Risk factor; Single nucleotide polymorphism

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms previously reported in Caucasians, ... more

H. Wang; Y. Zhao; J. Ma; G. Zhang; Y. Mu; G. Qi; Z. Fang; L. Wang; Q. Fan; Z. Ma
12/17/2012
Breast cancer; DNMT; Single nucleotide polymorphism; susceptibility

Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide ... more

M.Y. Sun; X.X. Yang; W.W. Xu; G.Y. Yao; H.Z. Pan; M. Li
12/17/2012
Breast cancer; Chinese Han population; MHC class-III; Single nucleotide polymorphism

Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried out a hospital-based case-control ... more

Q. Pan; Y. Ning; L.Z. Chen; S. Zhang; Z.Z. Liu; X.X. Yang; W. Wei; H. Wei; Q.G. Li; H.N. Yue; J.X. Wang
12/06/2012
Haplotype; Male infertility; Single nucleotide polymorphism; UBE2B

The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length polymorphism ... more

Y. Hu; W. Wen; J.G. Yu; S.Q. Qu; S.S. Wang; J. Liu; B.S. Li; Y. Luo
08/16/2012
Breeding value; Candidate gene; Chicken; Economic trait; Single nucleotide polymorphism

Neuropeptide Y (NPY) and gonadotrophin-releasing hormone receptor (GnRHR) are two candidate genes with a wide variety of physiological functions in growth and especially in reproduction processes. We examined the association of one SNP from each of these genes with growth- and egg production-related traits in Mazandaran native chickens. Two hundred and six individuals were genotyped by ... more

S.A. Fatemi; H. Mehrabani-Yeganeh; A. Nejati-Javaremi; S. Niknafs
05/09/2012
Mutation; NOD; SH2B3; Single nucleotide polymorphism

Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, with subsequent destruction of insulin-producing β-cells. Studies have identified strong associations between type 1 diabetes and several chromosome regions, including 12q24. Association between type 1 diabetes and 12q24 arises from SNP rs3184504; rs3184504 is a nonsynonymous SNP in ... more

Y.J. Li; X.Y. Li; X.R. Guo; Y. Li; B.F. Shen; Y.C. Shi; J.Y. Zhang
12/18/2014
Crohn’s disease; IRGM; Meta-analysis; Single nucleotide polymorphism

This meta-analysis was performed to evaluate the relationships between single-nucleotide polymorphisms (SNPs) in the immunity-related GTPase M (IRGM) gene and the risk of Crohn’s disease (CD). Eleven case-control studies were included, for a total of 5183 CD patients and 5571 healthy controls. Three common SNPs (rs13361189 C>T, rs10065172 C>T, and rs4958847 A>G) in the ... more

Y. Li; S.T. Feng; Y. Yao; L. Yang; Y. Xing; Y. Wang; J.H. You

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