Research Article

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Aldehyde dehydrogenase 2; Essential hypertension; Mongolian nationality; Single nucleotide polymorphism

Mongolians are known as heavy drinkers, and they have a high incidence of essential hypertension, which may be an associated pathology. We examined a possible association of essential hypertension and polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene in Mongolians from Inner Mongolia. Single nucleotide polymorphism rs671 of ALDH2 was detected by TaqMan PCR in 91 essential ... more

T. Hasi; L. Hao; L. Yang; X.L. Su
Association study; Major depressive disorder; Rs6311; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population

Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai ... more

T. Tencomnao; V. Thongrakard; W. Phuchana; T. Sritharathikhun; S. Suttirat
CDKAL1; Meta-analysis; Single nucleotide polymorphism; Type 2 diabetes

CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for rs10946398 variants of the CDKAL1 gene to ... more

M.A.S. Dehwah; M. Wang; Q.Y. Huang
Allele frequency; DNA; Pool; Single nucleotide polymorphism

We examined the efficiency of direct sequencing of pooled DNA for developing common single nucleotide polymorphisms (SNPs) and its accuracy for estimating allele frequencies. A pool of 200 control DNAs was established and was used for developing SNPs and estimating minor allele frequencies (MAF). The sensitivity of the pooled DNA method for successfully detecting an SNP with an MAF >0. ... more

M.K. Kim; T.S. Nam; K.H. Choi; S.Y. Jang; Y.O. Kim; M.C. Lee
Association study; DAT1; Major depressive disorder; rs40184; Single nucleotide polymorphism; Thai population

Several lines of evidence suggest that the dopaminergic system is involved in the pathophysiology of major depressive disorder (MDD). Since the dopamine transporter (DAT1, also known as SLC6A3), mediates the active reuptake of dopamine from the synapses and thereby plays a vital role in the regulation of dopaminergic neurotransmission, we looked for a possible association between the C/T ... more

N. Pattarachotanant; T. Sritharathikhun; S. Suttirat; T. Tencomnao
Association study; Psoriasis; Psoriasis subtype; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population

Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls ... more

C. Ronpirin; T. Tencomnao; J. Wongpiyabovorn
Chinese Han population; Hypertension; Single nucleotide polymorphism

Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of ... more

G.L. Hong; X.Z. Chen; Y. Liu; Y.H. Liu; X. Fu; S.B. Lin; Q. Zhu
Chinese sturgeon Acipenser sinensis; Hepatic lipase; Lipoprotein lipase; Mitochondrial control region; Performance on formulated diet; Single nucleotide polymorphism

It is very important to investigate the reasons for the large individual differences in individual performance of food acceptance when using formulated diets for the successful culture of larvae and juveniles of the Chinese sturgeon Acipenser sinensis. Genetic differences of the mitochondrial control region were investigated by direct sequencing in two groups of Chinese sturgeon ... more

Y. He; D. Shen; X.F. Liang; R.H. Lu; H. Xiao
Genotyping; Haplotype analysis; IL-10 gene promoter; Single nucleotide polymorphism

The purpose of this study was to determine whether interleukin-10 (IL-10) promoter polymorphisms are associated with leprosy or their subtypes in ethnic groups from southwest China. Genotyping using TaqMan® SNP Genotyping Master Mix and ABI 7500 real-time PCR system was performed for IL-10 T3575A, G2849A, C2763A, A1082G, C819T, and C592A in 189 healthy controls (40 ± 18 years) and 193 ... more

X.H. Chen; J.H. Xiong; Y. Ning; Y. Wen; J. Liu; C. Mao; X.M. Weng; J.C. Gu
Apoptosis; Cell cycle control; Childhood brain tumor; Single nucleotide polymorphism

We conducted a hospital-based case-control study in Korea to investigate whether apoptosis- and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms ( ... more

S. Jeon; S. Han; K. Lee; J. Choi; S.K. Park; A.K. Park; H.S. Ahn; H.Y. Shin; H.J. Kang; H.H. Koo; J.J. Seo; J.E. Choi; H. Kim; Y. Ahn; D. Kang