Research Article

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09/17/2012
Atherosclerosis; Mitochondrial DNA; Type 2 diabetes mellitus

Hyperglycemia-induced reactive oxygen species production can cause diabetes and its complications, including atherosclerosis. The role of mitochondrial DNA variants and mitochondrial copy number in the pathogenesis of diabetic atherogenesis is not well understood. We examined 36 diabetic patients who had undergone amputation for diabetic foot and seven non-diabetic patients who had ... more

M.C. Chien; W.T. Huang; P.W. Wang; C.W. Liou; T.K. Lin; C.J. Hsieh; S.W. Weng
05/16/2014
Atherosclerosis; Global DNA methylation; Homocysteine; Lectin-like oxidized LDL receptor-1

Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change in endothelial cells. ApoE-/- mice were divided into a ... more

X.L. Yang; J. Tian; Y. Liang; C.J. Ma; A.N. Yang; J. Wang; S.C. Ma; Y. Cheng; X. Hua; Y.D. Jiang
05/04/2015
Atherosclerosis; Diabetes mellitus; Diabetic foot; High mobility group box 1; Peripheral arterial occlusive disease

The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabetic patients, including 29 ... more

C.F. Tsao; W.T. Huang; T.T. Liu; P.W. Wang; C.W. Liou; T.K. Lin; C.J. Hsieh; S.W. Weng
02/20/2015
Coronary artery bypass surgery; Endothelial nitric oxide synthase; Gene transfection; Grafted artery; Spasm

This study established an animal model of coronary artery bypass graft (CABG) surgery. The human endothelial nitric oxide synthase (eNOS) gene was transfected into grafted arterial walls to verify transfection efficiency. Forty rabbits were randomized into the following 4 equal groups: 1) eNOS gene transfection group (eNOS group); 2) empty eNOS gene transfection group (empty gene group); ... more

Y. Zhu; H.S. Wang; X.M. Li; Z.W. Wang
11/23/2005
Ala16Val polymorphism; APOE gene polymorphism; Atherosclerosis; MnSOD gene polymorphism; ox-LDL; Oxidative damage; Oxidative stress

Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic cardiovascular risk factors. ox-LDL levels were measured by ... more

M.G.V. Gottlieb; C.H.A. Schwanke; A.F.R. Santos; P.F. Jobim; I.B.M. da Cruz; D.P. Müssel
10/07/2014
Atherosclerosis; Mononuclear cell; Stress; β2-AR

The aim of this study was to determine whether monocyte/macrophage β2-AR could act as the therapeutic target of antisympathetic excitation-induced atherosclerotic progression. Cultivated human THP-1 cells were divided into different groups and incubated with isoprenaline, metoprolol, propranolol or β2-AR blocker for 24 h, together with oxidized low-density lipoprotein (ox-LDL). Afterwards ... more

Y.L. Guo; J.Q. Zhou; C.Q. Xiang; W.H. Yang; B. Zhang; W.J. Dai; J.H. Liu; S.J. Zheng
04/22/2015
Aortic valve calcification; Atherosclerosis; Soluble receptor for advanced glycation end-products

The soluble receptor for advanced glycation end-products (sRAGE) shows a close relationship with atherosclerosis. The goal of this study was to compare the levels of sRAGE in patients with and without aortic valve calcification and to investigate the relationship between them. After transthoracic echocardiographic examination, 120 male patients with aortic valve calcification and 120 age ... more

H. Zheng; Y. Li; N. Xie; J.L. Huang; H.F. Xu; M. Luo
01/30/2015
Atherosclerosis; Fibroblast growth factor-23; Peritoneal dialysis

Several previous studies have demonstrated that elevated levels of fibroblast growth factor-23 (FGF-23) may be involved in atherosclerosis and contribute to the high mortality rate of peritoneal dialysis (PD) patients. The aim of this study was to determine the precise role of FGF-23 in the pathogenesis of atherosclerosis in PD patients. Between April 2009 and January 2012, 62 PD patients ... more

Y. Zeng; S. Feng; O.Y. Han; H.Y. Shen; D.H. Jin; Y.B. Shi
07/14/2015
4-dien-1-one (GBOT); 4-Dihydroxy-phenyl)-1-piperidin-1-yl-penta-2; 5-(3; Atherosclerosis; Blood glucose; Blood lipid metabolism

We observed the variation in in vivo blood lipid and blood glucose metabolism in rats with atherosclerosis after 5-(3,4-dihydroxy-phenyl)-1-piperidin-1-yl-penta-2,4-dien-1-one (GBOT) administration. Wistar rats aged 10 weeks received a high-fat diet to establish the atherosclerosis model. Metabolic indices related to blood lipid and blood glucose were measured before modeling ... more

A. Rong; G. Borjihan; Y.J. Qiao
02/22/2016
Atherosclerosis; Interleukin-4; M2 macrophage; MAPK signaling pathway

Our study aimed to investigate the effects of interleukin-4 (IL-4) on macrophage polarization, as well as its role in the development of atherosclerosis. Human peripheral blood mononuclear cells (PBMCs) were isolated and randomly divided into 3 groups: control group, ox-LDL group, and ox-LDL + IL-4 groups. The expression of M1/M2 macrophage surface markers such as TNF-α, CD68, and CD206 ... more

X.N. Zhao; Y.N. Li; Y.T. Wang; X.N. Zhao; Y.N. Li; Y.T. Wang

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