Research Article

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08/04/2009
Azoospermia; Chromosomal abnormality; Male infertility; Severe oligozoospermia; Y chromosome microdeletion

Infertility is defined as the inability to conceive a child after one year of regular unprotected intercourse; it is a major health problem affecting about 10-15% of all couples. Infertility is due to a male factor in approximately 50% of cases. The human Y chromosome contains genes necessary for gonadal differentiation into a testis and genes for complete spermatogenesis. We examined the ... more

G.G. Ceylan; C. Ceylan; H. Elyas
04/27/2012
Male infertility; mtDNA mutations; Y chromosome microdeletion

Infertility affects about 10-15% of all couples attempting pregnancy with infertility attributed to the male partner in approximately half of the cases. Proposed causes of male infertility include sperm motility disturbances, Y chromosome microdeletions, chromosomal abnormalities, single gene mutations, and sperm mitochondrial DNA (mtDNA) rearrangements. To investigate the etiology of ... more

A.I. Güney; D. Javadova; D. Kırac; K. Ulucan; G. Koc; D. Ergec; H. Tavukcu; T. Tarcan
07/08/2013
AZF microdeletions; Azoospermia; Glutamine and glycine repeat polymorphisms; Karyotype; Non-obstructive oligospermia

Chromosome abnormalities, Y-chromosome microde­letions, and androgen receptor gene CAG and GGN repeat polymor­phisms in infertile Chinese men featuring severe oligospermia and azoospermia were analyzed. Ninety-six fertile men and 189 non-ob­structive infertile men, including 125 patients with azoospermia and 64 with severe oligozoospermia, were studied. Seventeen infertile men (9.0%) ... more

T.T. Han; J. Ran; X.P. Ding; L.J. Li; L.Y. Zhang; Y.P. Zhang; S.S. Nie; L. Chen
08/16/2012
Array-comparative genomic hybridization; Azoospermia; Azoospermia factor; Chromosomal anomaly; Severe oligozoospermia

We investigated the frequency and types of Y-chromosome microdeletions and chromosomal anomalies in non-obstructive azoospermic and severely oligozoospermic infertile males in northeastern China. The sample consisted of 519 infertile males (456 azoospermic, 63 severely oligozoospermic). PCR assays for Y-chromosome microdeletions and chromosome analysis were performed on all patients and ... more

R.L. Dai; R.X. Wang; J.L. Jin; G.N. Niu; J.Y. Lee; S.B. Li; R.Z. Liu
06/30/2007
Assisted human reproduction; AZF; Male infertility; Y microdeletions

Microdeletions in Yq are associated with defects in spermatogenesis, while those in the AZF region are considered critical for germ cell development. We examined microdeletions in the Y chromosomes of patients attended at the Laboratory of Human Reproduction of the Clinical Hospital of the Federal University of Goiás as part of a screening of patients who plan to undergo assisted ... more

J.T. Arruda; B.M. Bordin; P.R. Santos; W.E.J.C. Mesquita; R.C.P.C. Silva; M.C.S. Maia; M.S. Approbato; R.S. Florêncio; W.N. Amaral; M.A.Rocha Filho; K.K.V.O. Moura
11/24/2009
Androgen receptor; AR gene; Male infertility; Spermatogenesis; Teratozoospermia

The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), ... more

W.E.J.C. Mesquita; M.S. Approbato; K.K.V.O. Moura; R.S.A. Jesuíno
09/08/2009
GSTM1; GSTT1; Male infertility; Xenobiotics

Male infertility is a heterogeneous disorder, with vari­ous genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxi­fying enzymes of phase II drug metabolism can modify their expres­sion or function, affecting the biotransformation of toxic ... more

A.C.F. Finotti; R.C.P.Costa e Silva; B.M. Bordin; C.T.X. Silva; K.K.V.O. Moura
07/08/2008
Male infertility; vertical transmission; Y chromosome

Male infertility is considered to be a difficult-to-treat condition because it is not a single entity, but rather reflects a variety of different pathologic conditions, thus making it difficult to use a single treatment strategy. Structural alterations in the Y chromosome have been the principal factor responsible for male infertility. We examined 26 family members of 13 patients with male ... more

R.G. Rodovalho; J.T. Arruda; K.K.V.O. Moura
06/29/2010
AZF regions; Male infertility; STS markers; Y-chromosome microdeletion

Infertility is a major reproductive health threat; the frequency of male infertility due to Y-chromosome microdeletions is 13-18% in the human population; these microdeletions involve recurrent loss of three non-overlapping regions designated as AZFa, AZFb and AZFc, associated with spermatogenic failure. Several contradictory reports have been published regarding deletion frequency based ... more

L.K. Pandey; S. Pandey; J. Gupta; A.K. Saxena
04/06/2010
Familial Mediterranean fever; Male infertility; Mediterranean fever gene

Male infertility is a common barrier that prevents successful conception. There have been reports of azoospermia in men with familial Mediterranean fever, some of whom had not been treated with colchicine. Variation in this disorder could be a risk factor for amyloidosis associated with azoospermia. We determined the frequency of 6 of the most common Mediterranean fever gene mutations, ... more

E.O. Etem; D. Erol; Y. Huseyin; A. Arslan

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