Research Article

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07/24/2013
Acute lymphoblastic leukemia; Childhood; GSTP1 polymorphism; Meta-analysis

Studies investigating the association between the glutathione S-transferase P1 (GSTP1) A1578G polymorphism and the risk of childhood acute lymphoblastic leukemia (ALL) report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, China National Knowledge ... more

G.Z. Huang; W. Shan; L. Zeng; L.G. Huang
07/08/2013
Association signal; Colorectal cancer; IL6 gene; Meta-analysis; Polymorphism

Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studies on the role of ... more

J.J. Hu; Z.T. Wang; J. Zhong
04/26/2013
A49G polymorphism; CTLA-4; Hashimoto’s thyroiditis; Meta-analysis

Published data on the association between the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and the risk for Hashimoto's thyroiditis (HT) are inconclusive. A meta-analysis was performed to derive a more precise estimation. Published case-control studies in English or Chinese were identified. In total, 24 studies with 2295 cases and 4521 controls were investigated. A ... more

R. Ji; Y. Feng; W.W. Zhan
04/02/2013
Endometriosis; Meta-analysis; Polymorphism; VEGF

Endometriosis is a chronic gynecological disease defined as the presence of the endometrium outside the uterine cavity. Endometriosis is a multifactorial and polygenic disease in which angiogenesis may be implicated. Angiogenesis is under the control of numerous inducers, including vascular endothelial growth factor (VEGF). Many studies have reported that VEGF plays a role in the ... more

Y.Z. Li; L.J. Wang; X. Li; S.L. Li; J.L. Wang; Z.H. Wu; L. Gong; X.D. Zhang
02/08/2013
-C509T polymorphism; IgA nephropathy; Meta-analysis; TGF-β1 gene

There are conflicting reports associating the TGF-β1 gene -C509T polymorphism with susceptibility to IgA nephropathy. We investigated this association through a meta-analysis. Case-control studies were searched up to January 2012; the genotype frequencies in the control group were found to be consistent with Hardy-Weinberg equilibrium. Publication bias was tested by funnel plot and the ... more

H. Wang; P. Li; Z.C. Feng
01/22/2013
ACE I/D polymorphism; Meta-analysis; OSAHS; Severity

Published data on a possible association between the angiotensin-converting enzyme (ACE) gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome (OSAHS) occurrence and its severity risk are inconclusive. We performed a meta-analysis of case-control studies published in English or Chinese. Thirteen studies, totaling 1361 cases and 1373 controls, were investigated for ... more

Y. Feng; J. Ri; H.Y. Wan; G.C. Shi; Q.Y. Li; L. Fan
12/17/2012
Gene polymorphism; LOC387715/ARMS2; Meta-analysis; Polypoidal choroidal vasculopathy

We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% ... more

J.J. Jiang; X. Wu; P. Zhou; W.Z. Yu; L.Z. Huang; X.X. Li
11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
10/04/2012
Glioma risk; MDM2; Meta-analysis; p53; Polymorphisms

Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies including ... more

J.N. Zhang; S.H. Yi; X.H. Zhang; X.Y. Liu; Q. Mao; S.Q. Li; W.H. Xiong; Y.M. Qiu; T. Chen; J.W. Ge
09/26/2012
Arg904Gln; Essential hypertension; Meta-analysis; Polymorphisms; TSC

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The pooled results showed no ... more

F. Zhang; Y. Yang; D. Hu; H. Lei; Y. Wang

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