Research Article

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Genetic polymorphisms; Meta-analysis; Prostate cancer; PTGS2

Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise estimation of this association, all available studies were ... more

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Androgen receptor (AR) gene; Prostate cancer; Prostate-specific antigen (PSA) gene; Trinucleotide repeats

The number of trinucleotide repeats [CAG (coding for polyglutamine), GGC (coding for polyglycine)] in the first exon of the androgen receptor (AR) gene and prostate-specific antigen (PSA) gene androgen response element I A/G polymorphism are both related to prostate cancer prognosis. We investigated whether these genomic changes occur in the AR and PSA genes, which are usually found in ... more

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5p15; Polymorphism; Prostate cancer

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Biochemical recurrence; miR-146a; Polymorphism; Prostate cancer

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were ... more

M. Chen; Z.Y. Zhou; J.G. Chen; N. Tong; S.Q. Chen; Y. Yang; X.W. Zhang; H. Jiang; N. Liu; J. Liu; G.Z. Sha; W.D. Zhu; L.X. Hua; Z.J. Wang; B. Xu
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Diabetes mellitus; Genetic polymorphisms; HNF1β; Meta-analysis; Prostate cancer

Polymorphism 17q12 rs4430796 within HNF1βis a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the ... more

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CSB; DNA repair-related genes; Prostate cancer; XPG

We aimed to investigate the association between genetic variants of the DNA repair genes XPG, CSB, XPC, CCNH, and MMS19L in the nucleotide excision repair (NER) pathway and risk of prostate cancer in a population in China. This study included 229 patients with newly diagnosed and histopathologically confirmed primary prostate cancer and 238 ... more

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Apoptosis; Bortezomib; NFkB pathway; Prostate cancer; Trichostatin A

Prostate cancer is one of the most common types of urological cancers. Despite the implementation of effective radiotherapy and chemotherapy methods, prostate cancer cells can still show resistance to treatment. In recent years, a combination of proteasome and histone deacetylase inhibitors has been used to treat various malignancies. In this study, we examined the cytotoxic and apoptotic ... more

I. Kiliccioglu; E. Konac; N. Varol; S. Gurocak; Y. Bilen
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DCG and links; Differentially co-expressed genes (DCG); Prostate cancer; Regulatory impact factor; Transcription factor

Microarray expression analysis was used to forecast the roles of differentially co-expressed genes (DCG) and DCG and links in the pathogenesis of prostate cancer. In addition, we demonstrate that the relationship between transcriptional factors (TFs) and their targets can be considered a key factor in determining the difference between primary and metastatic prostate cancer. Regulatory ... more

M.Q. Fan; P.X. Wang; J.Y. Feng; Y. Xiao; C.B. Huang
12/02/2013
Bone mesenchymal stem cells; OCT4; Overexpression; SOX2; Xiaomeishan porcine

Mesenchymal stem cells derived from bone marrow (BMSCs) are a population of self-renewing multipotent cells that are capable of differentiating into various cellular lineages, and are widely employed in tissue engineering and cell therapy. Recently, clinical research involving BMSCs has become increasingly popular. In order to conduct appropriate research, it is first necessary to amplify ... more

Y.X. Fan; C.H. Gu; Y.L. Zhang; B.S. Zhong; L.Z. Wang; Z.R. Zhou; Z.Y. Wang; R.X. Jia; F. Wang

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