Research Article

Related GMR Articles

NANOG; Neural differentiation; NT2/D1; OCT4; Proliferation; SOX2

SOX2, a universal marker of pluripotent stem cells, is a transcription factor that helps control embryonic development in vertebrates; its expression persists in neural stem/progenitor cells into adulthood. Considering the critical role of the SOX2 transcription factor in the regulation of genes required for self-renewal and pluripotency of stem cells, we developed and ... more

D. Drakulic; A. Krstic; M. Stevanovic
Bioinformatics; Brain; GPCR; Orphan receptor; Prostate cancer; Testis

G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant ... more

R.B. Parmigiani; G.S. Magalhães; P.A.F. Galante; C.V.B. Manzini; A.A. Camargo; B. Malnic
Gene set enrichment analysis; Meta-analysis; Prostate cancer

Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics of prostate cancer at the pathway level to search for such ... more

Q.Y. Ning; J.Z. Wu; N. Zang; J. Liang; Y.L. Hu; Z.N. Mo
Gene polymorphism; Meta-analysis; p53 codon 72; Prostate cancer

We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on all the studies showed no significant association ... more

M.S. Li; J.L. Liu; Y. Wu; P. Wang; H. Teng
GSTP1; Kashmir; Polymorphism; Prostate cancer; Restriction digestion; RFLP

Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investigate the GSTP1 Ile105Val genotype ... more

Q. Qadri; A.S. Sameer; Z.A. Shah; A. Hamid; S. Alam; S. Manzoor; M.A. Siddiqi
Functional similarity; Gene set; miRNA; mRNA; Prostate cancer; Target gene

Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abnormally expressed mRNAs ... more

H. Song; Y. Liu; J. Pan; S.T. Zhao
Association analysis; Multidrug resistance 1 gene; Prostate cancer; Risk factors; Single-nucleotide polymorphism

Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were ... more

F.R. Shen; C.Y. Yan; M. Liu; Y.H. Feng; Y.G. Chen
Fusion gene; Prostate cancer; Single-end reads

Fusion gene expression, a kind of chromosome rearrangement mode, has been strongly linked to prostate cancer diagnosis and prognosis as well as to the Gleason score and the American Joint Committee on Cancer stage assessment. In combination with traditional methods for locating fusion genes and scoring their association with cancer cell growth, proliferation, and invasion through the ... more

D.D. Xie; J.Y. Li; Y. Wang; L. Chen; D.X. Yu
Androgenic hormone; HNF1b; Mechanism; Prostate cancer

Prostate cancer is one of the most commonly diagnosed male malignancies. Genome wide association studies have revealed HNF1b to be a major risk gene for prostate cancer susceptibility. We examined the mechanisms of involvement of HNF1b in prostate cancer development. We integrated data from Gene Expression Omnibus prostate cancer genes from the Dragon Database of Genes ... more

Y.L. Hu; D. Zhong; F. Pang; Q.Y. Ning; Y.Y. Zhang; G. Li; J.Z. Wu; Z.N. Mo
Apoptosis; Invasion; miR-181b; PC-3; Proliferation; Prostate cancer

We examined microRNA-181b (miRNA) expression in prostate cancer tissues and its effect on the prostate cancer cell line PC-3. Tissues from 27 cases of prostate cancer and 30 samples of normal human prostate were collected by surgical removal. Total miRNA was extracted, and the relative expression of miR-181b was quantified using RT-PCR. miR-181b ASO was transfected into prostate cancer PC ... more

L. He; H. Yao; L.H. Fan; L. Liu; S. Qiu; X. Li; J.P. Gao; C.Q. Hao