Research Article

Related GMR Articles

01/30/2015
Gastric cancer; MicroRNA; Signet-ring cell carcinoma; Tubular adenocarcinoma

Gastric cancer is a disease with a heterogeneous pathology; its pathological mechanisms remain unclear because there is a poor understanding of its etiology. In this study, we identified differentially expressed microRNAs (miRNAs) among various gastric cancer subtypes. miRNA microarray analysis and bioinformatic analysis were used to compare miRNA expression between the signet-ring cell ... more

F.Q. Li; B. Xu; Y.J. Wu; Z.L. Yang; J.J. Qian
09/30/2007
Activated caspase-3; Apoptosis; Gastric cancer; Gastric dyspepsia; Helicobacter pylori; TUNEL

Apoptosis has an essential function in maintaining the integrity of the gastrointestinal mucosa. Its deregulation is associated with the occurrence of lesions such as in atrophic gastritis, peptic ulcers, intestinal metaplasia, and stomach tumorigenesis. Thus, the aim of the present study was to investigate the frequency of apoptotic cells (apoptotic index, AI) by using two different ... more

A.C. Targa; A.C.G. César; P.M. Cury; A.E. Silva
12/02/2013
Gastric cancer; HMG-box; HMGB3

Gastric cancer is a major health problem worldwide; it is the second most common cause of cancer death in the world. Recent studies indicate that the high-mobility group (HMG) of chromosomal proteins is associated with cancer progression. However, HMGB3 has been little studied. We analyzed the co-expression network between HMGB3 and differentially-expressed genes in the GSE17187 database ... more

Y. Gong; Y. Cao; L. Song; J. Zhou; C. Wang; B. Wu
09/26/2012
Bioinformatics analysis; Gastric cancer; Graph cluster

Despite a dramatic reduction in incidence and mortality rates, gastric cancer still remains one of the most common malignant tumors worldwide, especially in China. We sought to identify a set of discriminating genes that could be used for characterization and prediction of response to gastric cancer. Using bioinformatics analysis, two gastric cancer datasets, GSE19826 and GSE2685, were ... more

P. Liu; X. Wang; C.H. Hu; T.H. Hu
06/25/2012
cDNA microarray; differential gene expression; Gastric cancer; Peritoneal dissemination

With the aim of identifying peritoneal metastasis-related genes in gastric cancer, we performed a broad analysis of differential gene expression between the parental cell line GC9811 and its highly metastatic peritoneal counterpart, cell line GC9811-P. Two fluorescent cDNA probes, labeled with Cy3 and Cy5 dyes, were prepared from GC9811 and GC9811-P mRNA samples by the reverse ... more

F.H. Bai; N.J. Wang; J. Wang; L. Yang; F.M. Zhang; F. Yin; J. Liang; K.C. Wu; D.M. Fan
10/27/2014
5-Fluorouracil; Chemotherapy response; Excision repair cross-complimentary group 1; Gastric cancer; Survival time

We conducted a cohort study to investigate the role of 2 single-nucleotide polymorphisms of the excision repair cross-complimentary group 1 (ERCC1) gene polymorphism in response to chemotherapy and clinical outcomes of gastric cancer. A total of 231 patients with newly diagnosed and histopathologically confirmed primary gastric cancer participated in the study. ERCC1 rs11615 and rs3212986 ... more

L. Liu; C.H. Li; T.F. Jin; D.Y. Xu
09/12/2014
Gastric cancer; MLL3; Survival

Low expression of myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) is reportedly associated with gastric cancer and tumor progression. The purpose of this study was to examine the expression of MLL3 in tissue samples of patients with gastric cancer and to analyze the relationship between MLL3 protein expression and clinical records. Using immunohistochemical staining and Kaplan-Meier ... more

B. Li; H.Y. Liu; S.H. Guo; P. Sun; F.M. Gong; B.Q. Jia
09/12/2014
ERCC1; Gastric cancer; Oxaliplatin/5-Fu-survival; Response; XPF

We investigated the correlation between the response to chemotherapy in patients and excision repair cross-complimenta­ry group 1 gene (ERCC1) and xeroderma pigmentosum complemen­tation group F gene (XPF) polymorphisms and the effect of these polymorphisms on the clinical outcome of gastric cancer. Samples from a total of 255 patients with newly diagnosed and histopatho­ ... more

Z.H. Chen; L. Wang; L.P. Luo
08/28/2014
Apoptosis; Gastric cancer; Small interfering RNA; Survivin

A pair of inverted repeated sequences of the gene survivin was designed for stable double-stranded RNA establishment. After stable transfection, the biological behaviors of gastric cancer cells were observed. The interference rates of survivin-targeting siRNA (siRNA-survivin) in BGC823, MKN45, SGC7901, and cisplatin-resistant SGC7901 groups were 55.363 ± 3.974 ... more

Y.H. Li; M. Chen; M. Zhang; X.Q. Zhang; S. Zhang; C.G. Yu; Z.M. Xu; X.P. Zou

Pages