Research Article

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07/24/2014
Liver cancer; Meta-analysis; MicroRNA; Single nucleotide polymorphism

MicroRNAs (miRNAs) are small non-coding RNA molecules that play a fundamental role in controlling a variety of biological functions. Emerging evidence has shown that common genetic polymorphisms in miRNAs may be associated with the development of liver cancer; however, several individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise ... more

B.S. Wang; Z. Liu; W.X. Xu; S.L. Sun
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Insulin-induced gene 2; Obesity; Single nucleotide polymorphism

A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566605 SNP with obesity and other metabolic parameters in ... more

Y.D. Apalasamy; F.M. Moy; S. Rampal; A. Bulgiba; Z. Mohamed
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Association study; BRCA2; Cardiovascular disease; HapMap; Saudi Arabian population; Single nucleotide polymorphism

Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer. Recently, two single nucleotide polymorphisms (SNPs; rs11571836 and rs1799943) were identified, both located in untranslated regions of chromosome 13, associated with cardiovascular disease (CVD) in a multi-ethnic population. We examined the ... more

M. Alanazi; N.P. Reddy; J.P. Shaik; S.A. Ajaj; A.A.A. Jafari; H. Saeed; Z. Khan; A.P. Khan
05/09/2014
Colorectal cancer; Gastric cancer; Single nucleotide polymorphism; susceptibility

Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric cancer (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC and conducted this case-control study to assess the associations between these SNPs and the risk for GC in a southern Chinese population. All SNPs were ... more

C.P. Zhou; H.Z. Pan; F.X. Li; N.Y. Hu; M. Li; X.X. Yang
04/08/2014
Meat quality traits; MSTN gene; Rabbits; Single nucleotide polymorphism

We analyzed meat samples of nine pure lines of rabbit and its 37 hybrid combinations by sequencing and single-strand conformation polymorphism techniques to explore genetic polymorphisms of all the three exon regions and part of the 5'-regulatory region of the myostatin (MSTN) gene. Thus, we detected a single nucleotide mutation (T→C) on the 476 locus of the 5'-regulatory region ... more

X.B. Qiao; K.Y. Xu; B. Li; X. Luan; T. Xia; X.Z. Fan
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BMP-2; COL6A1; Genetic association; Ossification of the posterior longitudinal ligament; Single nucleotide polymorphism

COL6A1 and BMP-2 genes have been implicated in ossification of the posterior longitudinal ligament (OPLL) susceptibility in Japanese and Chinese Han populations. However, no study has yet investigated the DNA of unaffected family members of patients with OPLL. This study investigated differences in genetic polymorphisms of BMP-2 and COL6A1 between Korean patients with ... more

K.H. Kim; S.U. Kuh; J.Y. Park; S.J. Lee; H.S. Park; D.K. Chin; K.S. Kim; Y.E. Cho
02/27/2014
Apolipoprotein E; Chinese Hui population; Essential hypertension; Single nucleotide polymorphism

In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using ... more

Y. Yang; J.R. Xu; X.M. Liu; J. Zhou; B. Yang; M. Li; Y.J. Wang
02/13/2014
CYP2C9; Genotyping; Meloxicam; Single nucleotide polymorphism

The aim of this study was to investigate the effect of the CYP2C9*3 (CYP2C9 1075 A>C) polymorphism on meloxicam pharmacokinetics in a Chinese population. Twenty-four healthy volunteers were enrolled in this study. The pyrosequencing technique was used to identify polymorphisms of CYP2C9. The concentration of meloxicam in plasma was determined by a high-performance liquid chromatography ... more

M. Zhang; Y. Yang; G. Zhao; X. Di; L. Xu; N. Jiang; J. Xu; X. Xu
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Hepatocellular carcinoma; Molecular marker; Single nucleotide polymorphism; susceptibility; XRCC1 gene

The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in 460 HCC patients and 463 controls ... more

X.F. Li; Y.X. Chen; W.W. Ye; X.F. Tao; J.H. Zhu; S. Wu; L.Q. Lou
01/17/2014
Neovascular age-related macular degeneration; Polypoidal choroidal vasculopathy; Single nucleotide polymorphism; TLR3

Toll-like receptor 3 (TLR3) variants in mainland northern Chinese patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) were investigated. The complete genes of TLR3, including all exons and the promoter region, were assessed using direct sequencing technology of 284 unrelated mainland northern Chinese individuals: 96 nAMD patients, ... more

Y. Cheng; M.W. Li; H.P. Li; W.T. Zeng; P. Zhou; L.Z. Huang; X.X. Li; Y.Y. Sun

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