Research Article

Related GMR Articles

08/26/2011
Cathechol-o-methyltransferase; Dopamine D3 receptor; Polymerase chain reaction; Restriction fragment length polymorphism; Schizophrenia; Single nucleotide polymorphism

Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We investigated this apparent association between Ser9Gly (A/G) ... more

S.F. Tee; P.Y. Tang; H.C. Loh
11/02/2008
Leptin; obese gene; Polymerase chain reaction; Quantitative trait loci; Restriction fragment length polymorphism

The aim of the present study was to identify polymorphisms in the leptin gene of 112 pigs and compare the maternal and paternal lineage of Pietrain and Large White breeds that underwent a divergent selection for over 30 years. DNA samples extracted from the blood of these animals were amplified by polymerase chain reaction and genotyped by restriction fragment length polymorphism ... more

A.C.P. Silveira; R.C. Antunes; J.F. Almeida; T.F. Braga; P.F.A. Freitas; A.S.M. César; A.S.M. César; E.C. Guimarães
03/11/2008
composite heifers; Follicle-stimulating hormone receptor; Luteinizing hormone receptor; Restriction fragment length polymorphism; Sexual precocity

The purpose of the present research was to investigate the effects of polymorphisms of luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) genes, evaluated by polymerase chain reaction-restriction fragment length polymorphism in European-Zebu composite beef heifers from six different breed compositions. The polymorphism site analysis from digestion with Hha ... more

E.P. Marson; J.B.S. Ferraz; F.V. Meirelles; J.C.C. Balieiro; J.P. Eler
03/22/2012
BDNF; DARPP; Restriction fragment length polymorphism; Schizophrenia; SNP

A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two single nucleotide polymorphisms Val66Met of ... more

H.C. Loh; P.Y. Tang; S.F. Tee; T.J. Chow; Y.C. Cheah; S.S.J. Singh
12/04/2014
CYP1A1; CYP1A1m1; Glaucoma; Polymorphism; Primary open-angle glaucoma; Restriction fragment length polymorphism

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by ... more

N.B. Costa; C.T.X. Silva; A.B. Frare; R.E. Silva; K.K.V.O. Moura
10/20/2014
Epilepsy; Interleukin-1β gene; Interleukin-6 gene; Restriction fragment length polymorphism; Turkish population

In this study, we examined the frequency of polymorphisms in the interleukin (IL) genes IL-1β-511 and IL-6-174 in patients with epilepsy as well as a control group in Kars, Turkey. A total of 100 patients diagnosed with epilepsy and 100 nonepileptic subjects as a control group were examined. Peripheral blood samples were acquired from patients and ... more

İ. Gök; V. Esen; K. Ozlece
10/20/2014
ADRB2 gene polymorphisms; Body mass index; Obesity; Obstructive sleep apnea syndrome; Restriction fragment length polymorphism; Turkish population

We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral blood samples were taken ... more

İ. Gök; İ. Çelebi; N. Hüseyinoğlu; C. Özic
06/12/2015
Direct DNA sequencing; Glioma; Isocitrate dehydrogenase 1; Isocitrate dehydrogenase 2; R132H; Single-strand conformation polymorphism

Glioma is a term used to describe tumors derived from glial cells. These tumors are divided into subgroups based on the histological morphology and similarity of their differentiated glia cells. Traditionally, they are classified according to the World Health Organization and include astrocytomas, oligodendrogliomas, ependymomas, and oligoastrocytomas. Like most cancers, gliomas develop ... more

I.A. Pessôa; F.E.S. Sagica; N.P. Anselmo; J.R.N. Brito; E.H.C. de Oliveira
12/09/2008
Multidrug resistance; multidrug resistance protein; Single nucleotide polymorphism

One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance protein 1 (MRP1). We investigated ... more

F. Mahjoubi; S. Akbari; M. Montazeri; F. Moshyri
12/14/2011
Carcass traits; quantitative trait locus; Single nucleotide polymorphism; Sus scrofa chromosome 7 (SSC7)

Many QTLs for fatness traits have been mapped on pig chromosome 7q1.1-1.4 in various pig resource populations. Eight novel markers, including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and ... more

W.H. Huang; Z.X. Ma; Z.Y. Xu; Y.Z. Xiong; B. Zuo

Pages