Research Article

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08/07/2014
Gestational hypertension; LIPC gene; Lipid metabolism; Preeclampsia; SNP

We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) were recruited and genotyped using polymerase chain reaction- ... more

H. Lin; Z. Yin; X.Y. Yu; N. Lin; Y. Lin; J. Chen; Y.Z. Chen; K.P. Lu; H.K. Liu
05/09/2014
Radixin; Rheumatoid arthritis; SNP

Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like synoviocytes contributes to rheumatoid arthritis (RA) synovial ... more

H.K. Kim; J.S. Joo; H.Y. Lee; J.T. Kwon; D.R. Sohn; S.J. Hong; H.J. Kim
01/24/2014
FOLR1; Genotype; PCR-RFLP; PRLR; SNP

We investigated the polymorphisms of PRLR and FOLR1 genes in Xinong Saanen, Guanzhong, and Boer goat breeds by DNA sequencing and PCR–RFLP. Two novel SNPs were identified: KC109741: g.62130C>T in the 3ꞌ-UTR of goat gene PRLR, and KC136296: g.7884A>C in exon 3 of goat gene FOLR1. In the three goat breeds, the polymorphism information content was 0. ... more

J.X. Hou; F. Fang; X.P. An; Y. Yan; T. Ma; P. Han; F.X. Meng; Y.X. Song; J.G. Wang; B.Y. Cao
03/12/2014
Dopamine; DRD5; Haplotype; Paranoid schizophrenia; SNP

Dopamine (DA) has been implicated in the pathophysiol­ogy of several psychiatric disorders, including schizophrenia. Thus, genes related to the dopaminergic (DAergic) system are good candidate genes for schizophrenia. One of receptors of the DA receptor system is dopa­mine receptor 5 (DRD5). Single nucleotide polymorphisms (SNPs) in the regulatory regions of DRD5 gene may affect ... more

Y. Zhao; M. Ding; H. Pang; X.M. Xu; B.J. Wang
03/12/2014
5-HT; Haplotype; Paranoid schizophrenia; Serotonin; SNP; TPH2

In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 ... more

X.M. Xu; M. Ding; H. Pang; B.J. Wang
01/14/2014
Association analysis; Pig; Reproductive trait; RFRP gene; SNP

RFamide-related peptide (RFRP) gene is a crucial gene of the hypothalamo-pituitary-gonadal axis and plays an important role in reproduction regulation. This study aimed to clone and characterize the pig RFRP gene. We obtained a 645-bp cDNA of pig RFRP gene comprising a 546-bp open reading frame, which encoded a peptide of 188 amino acids. The pig RFRP coding ... more

M.X. Fang; Y.S. Huang; J. Ye; W. Zhang; Y. Li; Q.H. Nie
03/12/2014
AS-PCR (allele-specific PCR); IGFBP-5 gene; Pigs; SNP

The genetic resources and the mechanism of miniaturization in the Tibet Mini-pig have not been comprehensively studied. Polymorphisms in genes related to the insulin-like growth factor (IGF) axis have been investigated for years, but few on the polymorphism of IGF-binding protein-5 (IGFBP-5) in the Tibetan pig. In this study, allele-specific polymerase chain reaction (AS-PCR) was used to ... more

A.D. Chen; L.L. Hao; X.B. Fang; K. Lu; S.C. Liu; Y.L. Zhang
06/18/2015
Gene; Intracranial aneurysm; Risk factor; SNP

Few studies have examined the genes related to risk fac­tors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the ... more

L.T. Zhang; F.J. Wei; Y. Zhao; Z. Zhang; W.T. Dong; Z.N. Jin; F. Gao; N.N. Gao; X.W. Cai; N.X. Li; W. Wei; F.S. Xiao; S.Y. Yue; J.N. Zhang; S.Y. Yang; W.D. Li; X.Y. Yang
03/31/2015
Ancestry informative markers; Association studies; Brazilian genetic admixture; Ethnicity; Population structure; SNP

Genetic association studies determine how genes influence traits. However, non-detected population substructure may bias the analysis, resulting in spurious results. One method to detect substructure is to genotype ancestry informative markers (AIMs) besides the candidate variants, quantifying how much ancestral populations contribute to the samples’ genetic background. The present study ... more

A.V.C. Coelho; R.R. Moura; C.A.J. Cavalcanti; R.L. Guimarães; P. Sandrin-Garcia; S. Crovella; L.A.C. Brandão

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