Research Article

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03/13/2013
Cattle; CDIPT gene; PCR-RFLP; SNP; Ultrasound measurement traits

The CDIPT is crucial to the fatty acid metabolic pathway, intracellular signal transduction and energy metabolism in eukaryotic cells. We detected three SNPs at 3'-untranslated regions (UTR), named 3'-UTR_108 A > G, 3'-UTR_448 G > A and 3'-UTR_477 C > G, of the CDIPT gene in 618 Qinchuan cattle using PCR-RFLP and DNA sequencing methods. At each of the three SNPs, we ... more

C.Z. Fu; H. Wang; C.G. Mei; J.L. Wang; B.J. Jiang; X.H. Ma; H.B. Wang; G. Cheng; L.S. Zan
03/13/2013
Cattle; Hanwoo; Phospholipid transfer protein; Polymorphism; SNP

Phospholipid transfer protein (PLTP) regulates high-density lipoprotein metabolism. The gene encoding PLTP is located on bovine chromosome 13. The objective of this study was to identify single nucleotide polymorphisms (SNPs) in the Hanwoo (Bos taurus coreanae) PLTP gene to detect novel mutations affecting economically important traits. Five SNPs were identified in the coding ... more

J. Seong; J.D. Oh; H.K. Lee; G.J. Jeon; H.S. Kong
01/24/2013
Breeding; Fibroblast; Growth; QTL; SNP

In the past, the focus of broiler breeding programs on yield and carcass traits improvement led to problems related to meat quality. Awareness of public concern for quality resulted in inclusion of meat quality traits in the evaluation process. Nevertheless, few genes associated with meat quality attributes are known. Previous studies mapped quantitative trait loci for weight at 35 and 42 ... more

A.M. Felício; C. Boschiero; J.C.C. Balieiro; M.C. Ledur; J.B.S. Ferraz; A.S.A.M.T. Moura; L.L. Coutinho
10/04/2012
Makoei sheep; Myostatin gene; PCR; SNP; SSCP

Myostatin, a transforming growth factor-beta superfamily member, has been well documented as a negative regulator of muscle growth and development. Myostatin, which has 376 amino acids, is synthesized as a precursor protein. Polymorphism of the myostatin gene in Makoei sheep was investigated by PCR and single-strand conformation polymorphism technique (SSCP). Genomic DNA of 92 sheep was ... more

M. Farhadian; A. Hashemi; K. Mardani; R. Darvishzadeh; S. Jafari
05/15/2012
Cross-combination; Cyprinus carpio; DNA sequence; IGF2a; SNP

We studied whether two IGF2 transcripts in common carp are similar to those found in zebrafish. The full-length IGF2a cDNA contains a 5'-terminal untranslated region (UTR) of 105 bp, a 3'-terminal UTR of 1358 bp and an open reading frame of 612 bp, which encodes a 206-amino acid protein. A 6614-bp full-length IGF2a DNA molecule, including the 5'-flanking region ... more

S.Y. Su; Z.J. Dong; J.Q. Qu; Z.Y. Liang; J.Q. Zhang; L.X. Ma; W. Liu; P. Xu; X.H. Yuan
04/03/2012
meat quality; Mutation; Ryanodine receptor protein; SNP

Some genes affect meat quality in chickens. We looked for polymorphisms in the Gallus gallus α-RyR gene (homologous to RyR 1) that could be associated with PSE (pale, soft and exudative) meat. Because RyR genes are over 100,000 bp long and code for proteins with about 5000 amino acids, primers were designed to amplify a fragment of hotspot region 2, a region with a high density ... more

A.A. Droval; E. Binneck; S.R.R. Marin; F.G. Paião; A. Oba; A.L. Nepomuceno; M. Shimokomaki
03/16/2012
ATP1A1; Dairy cow; K+-ATPase; Mastitis; Na+; SNP; Somatic cell score

Mastitis affects the concentrations of potassium and sodium in milk. Since sodium-potassium adenosine triphosphatase (Na+, K+-ATPase) is critical for maintaining the homeostasis of these two ions, and is involved in cell apoptosis and pathogenesis, we presumed that polymorphism of the ATP1A1 gene, which encodes the bovine Na+, K+-ATPase ... more

Y.X. Liu; C.H. Xu; T.Y. Gao; Y. Sun
03/22/2012
BDNF; DARPP; Restriction fragment length polymorphism; Schizophrenia; SNP

A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two single nucleotide polymorphisms Val66Met of ... more

H.C. Loh; P.Y. Tang; S.F. Tee; T.J. Chow; Y.C. Cheah; S.S.J. Singh
01/31/2012
BMD; Genome-wide association studies; Osteoporotic fractures; SNP

Osteoporosis is a heritable disease characterized mainly by low bone mineral density (BMD) and/or osteoporotic fractures (OF). Most genome-wide association studies on osteoporosis have focused on BMD, whereas little effort has been expended to identify genetic variants directly linked to OF. To determine whether BMD-loci are also associated with OF risk, we performed a validation study to ... more

Y. Guo; J.T. Wang; H. Liu; M. Li; T.L. Yang; X.W. Zhang; Y.Z. Liu; Q. Tian; H.W. Deng
02/16/2012
CLPTM1L; Lung adenocarcinoma; Lung cancer; SNP; TERT

Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-control study in Shanghai was undertaken on 196 patients with ... more

X.F. Chen; S. Cai; Q.G. Chen; Z.H. Ni; J.H. Tang; D.W. Xu; X.B. Wang

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