Research Article

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12/04/2013
Breast cancer; POU5F1P1; PTPN13; TCF7L2

Recent genome wide association studies (GWAS) and candidate gene studies have revealed many novel loci associated with colorectal cancer susceptibility. We evaluated the effect of these colorectal cancer-associated variants on the risk of breast cancer in a Chinese Han population. Seven single nucleotide polymorphisms (SNPs) (rs3856806 in PPARG, rs7014346 in POU5F1P1, ... more

W. Wei; M. Jiang; L. Luo; Z. Li; P. Wang; W.Q. Dong
11/22/2013
BRCA1-interacting protein-terminal helicase 1; Breast cancer; Single nucleotide polymorphisms

BRCA1-interacting protein C-terminal helicase 1 (BRIP1) is a DNA helicase that influences the DNA repair ability and tumor suppressor function of BRCA1. Truncating BRIP1 mutations have been described as cancer susceptibility alleles. To evaluate BRIP1 polymorphisms as risk factors for breast cancer, we performed a detailed analysis of possible single nucleotide ... more

L.P. Ren; Y.S. Xian; D.M. Diao; Y. Chen; Q. Guo; C.X. Dang
11/18/2013
-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
11/07/2013
Breast cancer; C-erbB-2; CCR5; Immunohistochemistry; Ki-67; Prognostic indicator

We designed a 2-stage study to investigate chemotactic factor receptor 5 (CCR5) gene expression in breast cancer tissues and axillary lymph nodes and analyze the association between the CCR5-Δ32 gene polymorphism and the clinical features and prognosis of breast cancer patients. The first stage examined 72 cases of invasive ductal carcinoma and axillary lymph ... more

Y. Zhang; F.Y. Meng; W.L. Li; C.X. Zhou; Z. Guan; H.Y. Fan
01/04/2013
Breast cancer; Chromosome 17; FISH; Metastasis; TP53 gene

Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases. Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome. In about half of all human cancers, the tumor suppressor gene TP53, located at 17p13 ... more

D.S. Vasconcelos; F.P.E. da Silva; L.G. Quintana; N.P. Anselmo; M.A.K. Othman; T. Liehr; E.H.C. de Oliveira
06/13/2013
Bcl-2; Breast cancer; Ketamine

Ketamine is a dissociative anesthetic agent that has been widely used in surgery and for relieving pain in chronic cancer patients. We applied ketamine to breast cancer cell line MDA-MB-231 to detect the effect of treatment and molecular mechanisms involved. We found that ketamine can upregulate the level of anti-apoptosis protein Bcl-2, which promotes breast cancer cell invasion and ... more

H. He; J. Chen; W.P. Xie; S. Cao; H.Y. Hu; L.Q. Yang; B. Gong
12/17/2012
Breast cancer; DNMT; Single nucleotide polymorphism; susceptibility

Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide ... more

M.Y. Sun; X.X. Yang; W.W. Xu; G.Y. Yao; H.Z. Pan; M. Li
12/17/2012
Breast cancer; Chinese Han population; MHC class-III; Single nucleotide polymorphism

Polymorphisms of the major histocompatibility complex (MHC) have been linked to many diseases, especially autoimmune disorders. Previous studies have shown that genetic variants in MHC class III are associated with breast cancer. To determine if there is an association between MHC class III and breast cancer risk in the Chinese Han population, we carried out a hospital-based case-control ... more

Q. Pan; Y. Ning; L.Z. Chen; S. Zhang; Z.Z. Liu; X.X. Yang; W. Wei; H. Wei; Q.G. Li; H.N. Yue; J.X. Wang
11/28/2012
Biomarker; Breast cancer; Human mammaglobin; Prognostic factor

Different treatment outcomes and prognoses in patients with breast cancer can be observed with similar clinical predictors; this is because the biology of breast cancer is complex and heterogenous, involving multiple unknown contributing factors. We looked for plasma human mammaglobin (hMAM) mRNA by RT-PCR in 82 Korean patients with breast cancer to determine if there is an association ... more

G.W. Lee; J.Y. Kim; E.H. Koh; D. Kang; D.S. Choi; K.Y. Maeng; J.S. Lee
01/13/2012
Breast cancer; Migration; NM23H1; Sodium valproate

Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproate on breast cancer are insufficient in both animals and ... more

G.F. Li; T.L. Qian; G.S. Li; C.X. Yang; M. Qin; J. Huang; M. Sun; Y.Q. Han

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